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Kohara, Tokyo

Michinori Kohara, Tokyo JP

Patent application numberDescriptionPublished
20090148424Reversibly immortalized mammalian liver cells and use thereof - The present invention provides a reversibly immortalized mammalian liver cell line, especially CYNK-1 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Mar. 10, 2004, accession number: FERM BP-08657) comprising an immortalizing gene interposed between a pair of site-specific recombination sequences and a suicide gene in the outside of the pair of site-specific recombination sequences, characterized in that the suicide gene can exhibit its function after excision of the pair of site-specific recombination sequences, or passage cell line thereof; a mammalian liver cell obtained by excising the immortalizing gene from the reversibly immortalized mammalian liver cell line or passage cell line thereof; and use of these cells. By utilizing the reversibly immortalized mammalian liver cell line of the present invention enables the obtainment of the number of the liver cells and utilization as materials for artificial liver reactors and cell preparations.06-11-2009
20090214587Recombinant virus and use thereof - The present invention provides a recombinant virus which is efficacious and highly safe in preventing the onset of SARS infection and a vaccine for SARS coronavirus containing the same. The recombinant virus of the invention can express a SARS coronavirus gene.08-27-2009
20100152433ANTIVIRAL AGENT - The main purpose of the present invention is to provide a novel antiviral agent having a useful pharmacological action. The present inventors found that the above-described purpose can be achieved by a complex in which two synthetic RNAs (e.g., poly-I and poly-C) that can together form a double strand are contained in a drug carrier useful for transporting a drug into a cell (e.g., cationic liposome and atelocollagen), and thus the present invention was achieved.06-17-2010

Patent applications by Michinori Kohara, Tokyo JP

Ryota Kohara, Tokyo JP

Patent application numberDescriptionPublished
20090202041COMPTON CAMERA DEVICE - A Compton camera device according to the invention includes first means for reading coordinate data of a scattering point of a quantum ray detected by a pre-stage detector for each Compton scattering event, second means for reading coordinate data of a reaching point of the Compton-scattered quantum ray detected by a post-stage detector for each Compton scattering event, and third means for calculating a measurement accuracy of the scattered quantum ray by the first and second means for each Compton scattering event, calculating a statistical quantity of the quantum ray for each calculated measurement accuracy, and outputting the calculated statistical quantity to image reconstruction means.08-13-2009
20100019156NUCLEAR MEDICINE DIAGNOSIS APPARATUS - A nuclear medicine diagnosis apparatus comprising a mechanical collimator for effecting passage in a given direction of photons with given energy emitted from an object injected or dosed with a drug containing a radioactive isotope; a former-stage detector for detecting positional information at a point of reaction of photons having passed through the mechanical collimator and information on the momentum of charged particles generated by the reaction; a latter-stage detector disposed in the subsequent stage of the former-stage detector to detect information on the photons having been scattered by the former-stage detector; and image reconstruction means for reconstructing an image from detection information having been collected from the former-stage detector and latter-stage detector, wherein the image reconstruction means is built so that differentiation is carried out on the information on the photons having passed through the mechanical collimator and the information on the photons having been scattered by the former-stage detector and that the image reconstruction is carried out by different image reconstruction algorithms from the individual differentiated detection information.01-28-2010

Ryuichi Kohara, Tokyo JP

Patent application numberDescriptionPublished
20090190192Image reading apparatus and method for processing images - An image reading apparatus reads image information of an original document to produce image data having different data sizes. An image converting section converts the image information into a plurality of items of image data. A display section displays a plurality of items of information on the plurality of items of image data. A selecting section allows selecting of one of plurality of items of image data.07-30-2009

Patent applications by Ryuichi Kohara, Tokyo JP

Tatsuya Kohara, Tokyo JP

Patent application numberDescriptionPublished
20110118886SYSTEM STABILIZING DEVICE - A control unit of a system stabilizing device uses a fluctuation detecting block 05-19-2011

Teiji Kohara, Tokyo JP

Patent application numberDescriptionPublished
20100076396HYDROGENATED NORBORNENE-BASED RING-OPENING POLYMERIZATION POLYMER, RESIN COMPOSITION, AND MOLDED OBJECT - A hydrogenated norbornene ring-open polymer obtained by hydrogenating 80% or more of main-chain carbon-carbon double bonds of a ring-open polymer which is obtained by ring-opening polymerization of 2-norbornene is disclosed. The hydrogenated norbornene ring-open polymer has a weight average molecular weight (Mw) determined by gel permeation chromatography (GPC) of 50,000 to 200,000, a molecular weight distribution (Mw/Mn) of 1.5 to 10.0, and a melting point of 110 to 145° C. Also disclosed is a hydrogenated norbornene ring-open polymer (hydrogenated polymer) obtained by hydrogenating 80% or more of carbon-carbon double bonds of a ring-open polymer which is obtained by ring-opening copolymerization of 2-norbornene and a substituent-containing norbornene monomer, wherein the proportion of a repeating unit (A) derived from the 2-norbornene with respect to all repeating units is 90 to 99 wt % and the proportion of a repeating unit (B) derived from the substituent-containing norbornene monomer with respect to all repeating units is 1 to 10 wt %. The hydrogenated ring-open polymer has a melting point of 110 to 145° C. A resin composition and a molding material containing these hydrogenated polymers, a molded article, a resin film, a resin sheet, a multilayer laminate, a packing material, a molded article for medical supplies, a blister molding sheet, a blister molded article, and a multilayer blow-molded container made of these hydrogenated polymers are also disclosed.03-25-2010

Toshiyuki Kohara, Tokyo JP

Patent application numberDescriptionPublished
200901246182-MORPHOLINO-4-PYRIMIDONE COMPOUND - A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; represents a C05-14-2009
200902398646- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS - A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:09-24-2009