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Koberstein

Jeffrey T. Koberstein, New York, NY US

Patent application numberDescriptionPublished
20100331441FUNCTIONALIZATION OF ORGANIC SURFACES - The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C—H bonds, such as polymers having C—H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a terminal functional group is applied to the surface of an organic material that contains one or more C—H bonds. The heterobifunctional molecule can be bound to any surface having C—H bonds as the photoactive anchor can react with C—H bonds upon irradiation. The terminal functional group has a “click” functionality which can be utilized to functionalize the surface of the organic material with any desired functionalizing moiety having the orthogonal click functionality.12-30-2010
20110059264MODIFICATION OF SURFACES WITH NANOPARTICLES - Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles. In certain embodiments, the method can include attaching a plurality of photoactive linker to a surface of a substrate to obtain a photoactive surface, wherein each photoactive linker comprises a photoactive group and a binding group that attaches to the surface of the substrate; depositing nanoparticles to the photoactive surface, wherein the nanoparticles comprise reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive surface with radiation to react the photoactive group with the reactive group to functionalize the surface of the substrate with nanoparticles.03-10-2011

Jeffrey T. Koberstein, Storrs, CT US

Patent application numberDescriptionPublished
20080299046METHODS FOR CONTROLLING SURFACE FUNCTIONALITY OF METAL OXIDE NANOPARTICLES, METAL OXIDE NANOPARTICLES HAVING CONTROLLED FUNCTIONALITY, AND USES THEREOF - Methods for controlling surface functionality of metal oxide nanoparticles, nanoparticles having controlled surface functionality, and uses thereof are described herein. Methods for controlling the surface functionality of a metal oxide nanoparticle are can include attaching a ligand to a metal oxide nanoparticle, where the ligand can include a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Moreover, metal oxide nanoparticles having versatile ligands can include an anchoring portion that binds to the surface of the metal oxide nanoparticle and a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Uses thereof can include cancer detection, electronics, cosmetics, cellular delivery carriers, magnetic storage media, drug delivery carriers, nanocomposite formation for improved mechanical properties, and the like.12-04-2008
20090259016MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS - The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.10-15-2009
20100099580Photochemical methods and photoactive compounds for modifying surfaces - Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.04-22-2010
20100331198Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies - The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of 12-30-2010

Patent applications by Jeffrey T. Koberstein, Storrs, CT US

John Koan Koberstein, Albany, OR US

Patent application numberDescriptionPublished
20110125098Intravenous Catheter Anchor System and Method - An improved anchor system and method for holding an intravenous catheter to the patient's body is easier to clean thereby reducing the risk of infection. The system also includes an intravenous catheter that includes a main line, a yoke attached to the main line and two branch lines attached to the yoke an elastic band made of non-porous material and a neck lanyard with a clamp on one end. During use, the elastic band is positioned around the two lumens and then twisted into a figure eight configuration. Each lumen is then extended into one of the two loops formed on the elastic strap. The clamp on the lanyard is then attached to the crossover section of the elastic band located between the two loops. The clamp includes jaws that when released tightens each loop around the lumens thereby securely attaching the two lumens to the lanyard. The elastic band is sufficient in size and resiliency so that when the clamp is released, each loop may be stretched so that the lumens may be removed so that the elastic band may be replaced.05-26-2011

Manfred Koberstein, Troy, MI US

Patent application numberDescriptionPublished
20100186430Method and System for Detecting Low Refrigerant Charge and Air Conditioner Protection System - A method and system for detecting a low charge condition in an air conditioner for a vehicle. The system first determines whether noise factors are present that would interfere with reliably measuring a pressure delta. If noise factors are not present, the system determines a pressure delta value for the compressor by comparing the high side pressure when the clutch is engaged to a high side pressure when the clutch is disengaged. If the pressure delta value is less than a threshold value, a low charge condition may be recorded. When the number of low charge conditions detected exceeds a predetermined number of events, the system may set a temperature diagnostic trouble code, disable the air conditioning system and alert the driver of a potential problem.07-29-2010

Ralf Koberstein, Lorrach GE

Patent application numberDescriptionPublished
20100197733PYRROLIDINES AND PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to compounds of formula (I) wherein Y, A, N and R08-05-2010

Ralf Koberstein, Allschwil CH

Patent application numberDescriptionPublished
20110212968PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES - The invention relates to novel phenethylamide derivatives and their wherein A, B, R09-01-2011

Ralph Koberstein, Lorrach DE

Patent application numberDescriptionPublished
20100010226TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE - The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use01-14-2010