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Knipe

David Knipe, Aubumdale, MA US

Patent application numberDescriptionPublished
20100008944HERPES SIMPLEX VIRUS MUTANT AND USES THEREFORE - The invention generally provides therapeutic and prophylactic compositions that include a replication defective mutant HSV-2 virus having a mutation in a viral host shut-off protein, a herpes simplex virus having a mutation in a viral host shut-off protein and two additional mutations that render the virus replication defective, and related methods.01-14-2010
20110118332VIRAL MICRORNA - The present invention relates, in general, to micro RN As and. in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit such microRNAs and to methods of treatment based on the use of such agents.05-19-2011

David Knipe, Auburndale, MA US

Patent application numberDescriptionPublished
20090022783siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES - The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.01-22-2009

Richard L. Knipe, Mckinney, TX US

Patent application numberDescriptionPublished
20080293223Method for Manufacturing Strained Silicon - In accordance with a particular embodiment of the present invention, a method for manufacturing strained silicon is provided. In one embodiment, the method for manufacturing strained silicon includes inducing a curvature in a silicon wafer, depositing an epitaxial layer of silicon upon an upper surface of the silicon water while the silicon wafer is under the induced curvature, and releasing the silicon wafer from the induced curvature, after depositing the epitaxial layer, such that a strain is induced in the epitaxial layer.11-27-2008
20100116632METHOD OF USING A PLURALITY OF SMALLER MEMS DEVICES TO REPLACE A LARGER MEMS DEVICE - Embodiments disclosed herein generally include using a large number of small MEMS devices to replace the function of an individual larger MEMS device or digital variable capacitor. The large number of smaller MEMS devices perform the same function as the larger device, but because of the smaller size, they can be encapsulated in a cavity using complementary metal oxide semiconductor (CMOS) compatible processes. Signal averaging over a large number of the smaller devices allows the accuracy of the array of smaller devices to be equivalent to the larger device. The process is exemplified by considering the use of a MEMS based accelerometer switch array with an integrated analog to digital conversion of the inertial response. The process is also exemplified by considering the use of a MEMS based device structure where the MEMS devices operate in parallel as a digital variable capacitor.05-13-2010
20100237738MOVING A FREE-STANDING STRUCTURE BETWEEN HIGH AND LOW ADHESION STATES - Embodiments disclosed herein generally solve a stiction problem in switching devices by using a series of pulses of force which take the switch from being strongly adhered to a landing electrode to the point where it is only weakly adhered. Once in the low adhesion state, the switch can then be pulled away from contact with a lower force provided by either the spring constant of the switch and/or the electrostatic forces resulting from low voltages applied to nearby electrodes.09-23-2010
20110043892FABRICATION OF A FLOATING ROCKER MEMS DEVICE FOR LIGHT MODULATION - The current disclosure shows how to make a fast switching array of mirrors for projection displays. Because the mirror does not have a via in the middle connecting to the underlying spring support, there is an improved contrast ratio that results from not having light scatter off the legs or vias like existing technologies. Because there are no supporting contacts, the mirror can be made smaller making smaller pixels that can be used to make higher density displays. In addition, because there is not restoring force from any supporting spring support, the mirror stays in place facing one or other direction due to adhesion. This means there is no need to use a voltage to hold the mirror in position. This means that less power is required to run the display.02-24-2011
20110079495MICROMECHANICAL DIGITAL CAPACITOR WITH IMPROVED RF HOT SWITCHING PERFORMANCE AND RELIABILITY - The present invention generally relates to RF MEMS devices that are capable of hot switching. The RF MEMS devices, by utilizing one or more spring mechanisms, are capable of hot switching. In certain embodiments, two or more sets of springs may be used that become engaged at specific points in the displacement of the cantilever of the MEMS device. The springs allow for a significant increase in the release voltage for a given pull in landing voltage.04-07-2011

Patent applications by Richard L. Knipe, Mckinney, TX US

Stephen Knipe, Hampshire GB

Patent application numberDescriptionPublished
20110089066COVER FOR CLOSING A CONTAINER04-21-2011

Steve Knipe, Hampshire GB

Patent application numberDescriptionPublished
20110272459CUP - Cup having a base and an adjoining shell, it being possible for the shell to be provided with a mouth roll at its opposite end to the base and to be configured with a single layer or multiple layers, at least one layer of the shell being produced from paper or cardboard or other comparable materials, at least one layer of the shell being provided with elevations and/or depressions substantially over its entire height and at least approximately the entire circumference, the difference in depth between the maximum elevation or depression and the material layer or the depression or elevation varying over the height of the shell and/or over the circumference, and it being possible for the mouth roll to be formed integrally on the inner layer or the only layer.11-10-2011