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Knight, PA
David M. Knight, Radnor, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100021477 | DESIGN AND GENERATION OF HUMAN DE NOVO pIX PHAGE DISPLAY LIBRARIES - Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies. | 01-28-2010 |
David M. Knight, Benwyn, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120063998 | Method for Treating Psoriatic Arthritis by Administering an Anti-IL-12 Antibody - Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriatic arthritis. | 03-15-2012 |
Linda Knight, Bryn Mawr, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100284921 | TARGETED NANOPARTICLES FOR INTRACELLULAR CANCER THERAPY - This invention provides constructs comprising a targeting member immobilized on a detectable particulate, in which binding of the targeting member to a target structure on a surface of a cancer cell triggers internalization of the construct. Such constructs can be used to identify or monitor cancer cells in cell cultures or in a tissue. Such construct can also be used to kill or prevent growth of cancer cells in vivo. Also included in the invention are methods for killing or preventing growth of cancer cells in vivo. | 11-11-2010 |
Marc Knight, Parkesburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110231055 | MAINTENANCE SYSTEM AND METHOD FOR VEHICLE FLEETS - A system and method for managing a fleet of vehicles including a control unit on one or more vehicles in the fleet of vehicles, a data collection unit on one or more vehicles in the fleet of vehicles in communication with the control unit, a server having an operational database for receiving data from one of the control unit and the data collection unit, and a telemetry module having access to the operational database for initiating an action based on an analysis of data on the server. | 09-22-2011 |
Michael J. Knight, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080270110 | AUTOMATIC SPEECH RECOGNITION WITH TEXTUAL CONTENT INPUT - A method of recognizing speech includes extracting textual content from a visual content time segment associated with a rich media presentation. A textual content input comprising a word from the extracted textual content is created. The textual content input is provided to an automatic speech recognition algorithm such that there is an increased probability that the automatic speech recognition algorithm recognizes the word within an audio content time segment associated with the rich media presentation. | 10-30-2008 |
| 20080270138 | AUDIO CONTENT SEARCH ENGINE - A method of generating an audio content index for use by a search engine includes determining a phoneme sequence based on recognized speech from an audio content time segment. The method also includes identifying k-phonemes which occur within the phoneme sequence. The identified k-phonemes are stored within a data structure such that the identified k-phonemes are capable of being compared with k-phonemes from a search query. | 10-30-2008 |
| 20080270344 | RICH MEDIA CONTENT SEARCH ENGINE - A method of generating a set of search results. An audio content search results set including an individual audio content search result corresponding to a rich media time segment is generated. A visual content search results set including an individual visual content search result corresponding to the rich media time segment is also generated. A relevance of the rich media time segment is determined based at least in part on an individual search result count. The individual search result count is a sum of a number of individual audio content search results corresponding to the rich media time segment and a number of individual visual content search results corresponding to the rich media time segment. The rich media time segment is included in an ordered set of search results, wherein an order of the rich media time segment is based at least in part on the determined relevance. | 10-30-2008 |
Richard Knight, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090305031 | NANODIAMOND MANUFACTURE AND PROCESS FOR MAKING THEREOF - Disclosed are novel coatings and other components of articles of manufacture featuring the inclusion of nanodiamonds therein. Also disclosed are methods of achieving such inclusion and methods of utilizing the resultant, improved articles. | 12-10-2009 |
Steven D. Knight, West Chester, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100069453 | Certain Chemical Entities, Compositions, and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 03-18-2010 |
Steven D. Knight, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080255182 | Certain chemical entities, compositions, and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 10-16-2008 |
| 20090286841 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 11-19-2009 |
| 20090306127 | Certain Chemical Entities, Compositions and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 12-10-2009 |
| 20090312365 | Certain Chemical Entities, Compositions, and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 12-17-2009 |
Steven David Knight, West Chester, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090005580 | Compounds, compositions and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 01-01-2009 |
| 20100105767 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 04-29-2010 |
| 20110230550 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 09-22-2011 |