| Patent application number | Description | Published |
|---|
| 20080219931 | Amyloid Imaging as a Surrogate Marker for Efficacy of Anti-Amyloid Therapies - The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent. | 09-11-2008 |
| 20080274058 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins - Benzofuran compounds which contain at least one detectable label selected from the group consisting of | 11-06-2008 |
| 20080286202 | Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition - A method of identifying a patient as prodromal to a disease associated with amyloid deposition by imaging techniques is provided. In addition, a method of identifying amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology by imaging techniques is provided. The methods discloses substances which are used for imaging and generating data which can be used to determine progress of an asymptomatic patient to a disease associated with amyloid deposition, or to identify amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology. | 11-20-2008 |
| 20080305040 | In Vivo or in Vitro Method For Detecting Amyloid Deposits Having at Least One Amyloidogenic Protein - An amyloid deposit can be detected by administering to a subject or applying to a sample a compound of Formula (I) or Formula (II) or structures 1-45, as described, and then imaging to detect binding of the compound to an amyloid deposit, where the amyloido genie protein of the deposit can be AL, AH, ATTR, Aβ2M, AA, AApoAI, AApoAII, AGeI, ALys, AFib, ACys, ABri, ADan, APrP, ACaI, AlAPP, AANF, APro, AIns, AMed, AKer, A(tbn), and/or ALac. | 12-11-2008 |
| 20090087376 | Heterocyclic Dye Compounds For In Vivo Imaging And Diagnosis Of Alzheimer's Disease - The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as exemplified by compounds of the formula (1) in which Y is independently S, O, or N and m is 1, 2, or 3. | 04-02-2009 |
| 20090142269 | ISOTOYPICALLY-LABELED BENZOTHIAZOLE COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS - The present invention provides an isolated linezolid impurity, desfluoro linezolid, the preparation thereof and its use as a reference standard. | 06-04-2009 |
| 20100021388 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 01-28-2010 |
