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Klug
Aaron Klug, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20090186816 | POLYPEPTIDE TARGETING TO MITOCHONDRIA - Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA. | 07-23-2009 |
David Klug, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20080291441 | Spectroscopic Support - A porous sample support provides a matrix into the pores or interstitial spaces of which a sample to be subjected to a spectroscopic analysis can be introduced. 2 D infrared spectroscopy can then be carried out on the sample at higher concentrations with minimized background. | 11-27-2008 |
| 20080291444 | Method of Spectroscopy - A method of multidimensional spectroscopy has a controllable excitation source parameter and comprises controlling said controllable parameter to excite a vibrational mode of the sample, generating a homodyne reflected signal from the sample and obtaining a spectrum of the sample from the reflected signal. | 11-27-2008 |
David R. Klug, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20090239250 | METHOD FOR THE ANALYSIS OF CELLS - The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector. | 09-24-2009 |
David Rupert Klug, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20090268200 | APPARATUS AND METHOD FOR OBTAINING SPECTRAL INFORMATION - A method of obtaining spectral information comprises initiating at least a first excitation at a first excitation frequency and a second excitation at a second frequency in a surface enhanced sample. The method further comprises varying one of said first and second excitation frequencies, detecting an output signal having an output signal strength and identifying an output signal peak. In addition the method includes correlating the identified output signal with the first and second excitation frequencies to obtain spectral information, in which the surface enhanced sample substrate is configured to enhance the field corresponding to at least one of the first and second excitation, or output fields initiated in this sample. | 10-29-2009 |