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Kleinfeld, US
Alan Kleinfeld, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100292086 | METHOD OF SCREENING FOR METABOLITE TRANSPORT MODIFIERS - Methods for discovering compounds that modulate metabolite transport across cell membranes are disclosed. Fluorescently labeled protein probes which have an affinity for an unbound metabolite are trapped in cells. The influx of the unbound metabolite into the cell causes a change in the fluorescence of the protein probe. The ability of test compounds to modulate the fluorescent signal is used to screen for compounds which affect transport of the unbound metabolite. In an example, the unbound metabolite is an unbound free fatty acid and the probe is a fatty acid binding protein. | 11-18-2010 |
Alan Marc Kleinfeld, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090318299 | DEVELOPMENT AND USE OF FLUORESCENT PROBES OF UNBOUND ANALYTES - A method for high throughput screening of probes is described. These probes are useful for characterization and measurement of unbound metabolites in a fluid sample, particularly characterization and measurement of levels of unbound free fatty acids. By practice of the disclosed invention, a profile of unbound metabolites can be determined for an individual which can be used to determine the individual's relative risk for disease such as stroke, cardiac disease and cancer. | 12-24-2009 |
| 20100062948 | USE OF PROBES FOR UNBOUND METABOLITES - Methods of determining levels of unbound metabolites are disclosed. Probes derived from fatty acid binding protein muteins are described that bind preferentially to a number of unbound metabolites including oleate, stearate, linoleate, palmitate, arachidonate and unconjugated bilirubin. A profile for a patient is determined using one or more of the described probes. The profile is useful in diagnosis of disease, particularly myocardial infarction, non-alcoholic fatty liver disease (NAFLD), diabetes, stroke, sepsis and neonatal jaundice. The responses of multiple probes to a test sample are used to classify the degree of acute coronary syndrome by comparison to multi-probe profiles generated from unstable angina, non ST elevation myocardial infarction, and ST elevation myocardial infarction. | 03-11-2010 |
| 20100298162 | DEVELOPMENT AND USE OF CYSTEINE-LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES - A method for high throughput discovery of proteins fluorescently labeled at a cysteine residue and that undergo a change in fluorescence ratio at 2 wavelengths upon binding an unbound analyte is described. Probes are disclosed which are labeled at a cysteine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for characterization and measurement of hydrophobic species in a fluid sample, particularly characterization and measurement of levels of unbound free fatty acids. A profile of unbound free fatty acids can be determined for an individual which can be used to determine the individual's relative risk for disease. | 11-25-2010 |
Brian J. Kleinfeld, Saginaw, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110059803 | Constant Velocity Joint - A boot assembly and constant velocity joint utilizing the boot assembly is provided. The constant velocity joint and boot assembly includes a first shaft, the first shaft having an axle portion extending between a first end and a second end, at least one of the first end and the second end having an enlarged joint portion. It also includes a hollow boot disposed on the first shaft having a joint end and a shaft end, the joint end disposed proximate the enlarged joint portion and the shaft end disposed proximate the axle portion. The constant velocity joint also includes a spacer, the spacer having an inner surface disposed on the axle portion and an outer surface having the shaft end of the boot disposed thereon. | 03-10-2011 |
Chris Kleinfeld, Olivet, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110072807 | Combined Exhaust Gas Aftertreatment/Air Cleaner Dust and Ejector Unit - A combined exhaust gas aftertreatment/dust ejector unit ( | 03-31-2011 |
Christopher J. Kleinfeld, Olivet, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110252788 | Bypass Fluid System For Exhaust Aftertreatment - An exhaust treatment system for a vehicle includes an intake conduit adapted to receive pressurized intake air provided from a turbocharger compressor and supply the pressurized intake air to an internal combustion engine. An uninterrupted bypass conduit bypasses the internal combustion engine and includes upstream and downstream ends. The upstream end branches from the intake conduit. An exhaust conduit includes an upstream end adapted to receive exhaust from the internal combustion engine. An upstream end of a mixing tube is fixed to and in fluid communication with a downstream end of the exhaust conduit and the downstream end of the bypass conduit at a tubular joint, wherein the exhaust and the pressurized intake air are mixed within the mixing tube. An exhaust treatment device is in fluid communication with a downstream end of the mixing tube. | 10-20-2011 |
David Kleinfeld, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100278746 | Method for Measuring Neurotransmitters in Vivo - A method is provided for in vivo detection of a biochemical substance in an animal by culturing neurofluocytes that stably express a receptor of the biochemical substances by transfecting cells with cDNA of the receptor and a tag that will emit a detectable energy in the presence of the biochemical substance, implanting the neurofluocyte into the animal's brain; and detecting the energy emission of the tag. In a first embodiment, the biochemical substance is a neurotransmitter, the tag is a fluophore, and the step of detecting includes forming an opening in the animal's skull and optically detecting fluorescent emissions using a two-photon laser scanning microscope. Multiple biochemical substances can be simultaneously detected by culturing neurofluocytes that express different receptors and have different fluophor tags that produce fluorescent signals at distinguishable wavelengths. | 11-04-2010 |
David Kleinfeld, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110297651 | Spatially chirped pulses for femtosecond laser ablation through transparent materials - Temporal focusing of spatially chirped femtosecond laser pulses overcomes previous limitations for ablating high aspect ratio features with low numerical aperture (NA) beams. Simultaneous spatial and temporal focusing reduces nonlinear interactions, such as self-focusing, prior to the focal plane so that deep (˜1 mm) features with parallel sidewalls are ablated at high material removal rates. | 12-08-2011 |