Patent application number | Description | Published |
20090197864 | Furo- and Thieno [3,2-c] Pyridines - Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula I, and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET. | 08-06-2009 |
20090286768 | SUBSTITUTED IMIDAZOPYR- AND IMIDAZOTRI-AZINES - Fused pyridine-based bicyclic compounds having the structure of Formula I, as defined herein, pharmaceutically acceptable salts thereof, preparation, compositions, and disease treatment therewith. This abstract does not define or limit the invention. | 11-19-2009 |
20110224191 | Substituted Pyrrolo[2,3-b]-Pyridines and -Pyrazines - Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met. | 09-15-2011 |
20110281888 | Fused Bicyclic Kinase Inhibitors - Compounds of Formula I, as shown below and defined herein: | 11-17-2011 |
20120046267 | 7-AMINOFUROPYRIDINE DERIVATIVES - Compounds of Formula 1, as shown below and defined herein: | 02-23-2012 |
20130253197 | FUSED BICYCLIC KINASE INHIBITORS - Compounds of Formula I, as shown below and defined herein: | 09-26-2013 |
Patent application number | Description | Published |
20090325863 | Somatostatin analogs and IGF-I inhibition for breast cancer prevention - The present invention relates generally to the use and application of compounds or agents, including somatostatin analogs, with effect on, affinity for, or specificity to SSTR3 and/or SSTR5 somatostatin receptors, particularly in the breast, for the treatment of breast hyperplasia, pre-neoplastic lesions and breast carcinoma and/or prevention or reduction of risk for breast cancer or treatment of breast cancer, including DCIS. The invention also relates to use of somatostatin analog SOM230 in treatment of breast hyperplasia and/or prevention or treatment of breast cancer. The invention includes assays and methods for screening and identifying breast hyperplasia with elevated SSTR3 and/or SSTR5 receptors and for chemotherapy and identifying compounds of use in the invention which are specific for, modulate via, or bind to SSTR3 and/or SSTR5 receptors. | 12-31-2009 |
20120141506 | TREATMENT OF NON-PROLIFERATIVE CYSTIC DISEASE - The present invention relates generally to the treatment of non-proliferative cystic disease of the breast. More particularly, the present invention relates generally to the treatment of non-proliferative cystic disease of the breast in BRCA1 mutant carriers. Accordingly, the invention relates to the use and application of compounds or agents, including somatostatin analogs, that inhibit insulin-like growth factor I (IGF-I) or insulin-like growth factor I receptor signaling for the treatment of non-proliferative cystic disease of the breast. The invention further relates to the use and application of these compounds or agents for the treatment of non-proliferative cystic disease of the breast in BRCA1 patients. The invention also relates to use of somatostatin analog SOM230 in treatment of non-proliferative cystic disease of the breast and more particularly, to use of somatostatin analog SOM230 in treatment of BRCA1 associated non-proliferative cystic disease. | 06-07-2012 |
20130058950 | METHODS FOR DETECTING PROGENITOR CELLS AND USES THEREOF - Diagnostic and therapeutic methods pertaining to diseases and disorders of the breast, uterus and ovary are encompassed herein. More particularly, diagnostic methods for early detection of progenitor cells of breast, uterine, and ovarian cancers are described herein. The identification of markers for these cancer predisposing progenitor cells, which co-express the progesterone receptor (PR) and p63, provides tools and methods of use thereof that facilitate early detection of increased frequency of PR/p63 double positive (PR/p63+) progenitor cells in asymptomatic patients and thus, early detection of increased cancer risk in such patients and assessment, diagnostic stratification, and evaluation of therapeutic intervention in symptomatic patients. Therapeutic methods are also encompassed herein, which include detection of PR/p63+ progenitor cells in a patient, wherein detection of increased frequency of PR/p63+ progenitor cells provides information on which basis a determination of therapeutic regimen or an assessment of an ongoing therapeutic regimen can be made. | 03-07-2013 |
20130261057 | METHODS FOR THERAPEUTIC TREATMENT OF BENIGN PROSTATIC HYPERTROPHY (BPH) - Therapeutic methods for treatment of benign prostatic hypertrophy by inhibition of the activity of insulin-like growth factor-I (IGF-I) are described herein. Methods encompass the use of IGF-I antagonists, as well as the use of compounds that lower the effective level of IGF-I or interfere with post receptor effects of IGF-I action in the prostate. | 10-03-2013 |
20140349937 | METHODS FOR TREATING BENIGN PROSTATIC HYPERTROPHY (BPH) - Therapeutic methods for treating a subject with benign prostatic hypertrophy by inhibition of the activity of insulin-like growth factor-I (IGF-I) to reduce the amount of prostatic hyperplastic tissue in the subject are described herein. | 11-27-2014 |
Patent application number | Description | Published |
20080233054 | DENTAL ANTI-HYPERSENSITIVITY COMPOSITION AND METHOD - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 09-25-2008 |
20110111361 | Device For The Detection Of Non-Cavitated Early Dental Caries Lesions - The invention provides a device for detecting non-cavitated caries lesions, including a measuring electrode having an electrically conductive tip. The tip is dimensionally configured to fit within a fissure and provide electrical contact with a patient's tooth. A reference electrode is also included, the reference electrode being configured for electrical contact with the patient's body. A measuring means is also provided for determining electrical conductance between the measuring electrode and the reference electrode, wherein the device is further configured to receive a current source for providing electrical current between the measuring electrode and the reference electrode. | 05-12-2011 |
20120027828 | Dental anti-hypersensitivity composition and method - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 02-02-2012 |
20140120142 | Dental Anti-Hypersensitivity Composition and Method - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 05-01-2014 |
Patent application number | Description | Published |
20080204013 | LOGGING METHOD FOR DETERMINING CHARACTERISTIC OF FLUID IN A DOWNHOLE MEASUREMENT REGION - For use in logging downhole in an earth borehole, a method for determining a characteristic of oil that may be present in a downhole measurement region, includes the following steps: providing a plurality of crude oil samples; determining the viscosities of the crude oil samples; performing test measurements, using a predetermined operating mode, on media including the crude oil samples to obtain test data; applying a test processing procedure to the test data to obtain an output test parameter relating to the test data and the predetermined operating mode; deriving, for the plurality of crude oil samples, a correlation relating the output test parameter to the viscosities of the crude oil samples; performing downhole measurements in the measurement region with a logging device, operated with substantially the predetermined operating mode, to obtain logging data, and applying a measurement processing procedure to the logging data to obtain an output logging parameter; and determining the oil characteristic using the output logging parameter and the correlation. | 08-28-2008 |
20110174694 | PRODUCING HYDROCARBONS FROM OIL SHALE BASED ON CONDITIONS UNDER WHICH PRODUCTION OF OIL AND BITUMEN ARE OPTIMIZED - Kerogen in oil shale is converted to bitumen, oil, gases and coke via a retorting process. The vaporizable oil and gases are then recovered. Following the retorting process, bitumen is recovered via solvent extraction. The overall conversion process is enhanced by calculating conditions to optimize recovery of both oil and bitumen. This can be accomplished by either separately calculating conditions for which production of vaporizable oil and production of bitumen are optimized, or calculating conditions for which production of vaporizable oil and production of bitumen are optimized by applying a maximizing function to combined vaporizable oil and bitumen data. An advantage of this technique is that greater efficiency is achieved because the time duration of heating associated with the retorting process can be reduced and product yields increased. | 07-21-2011 |
20120125602 | Monitoring Injected Nonhydrocarbon And Nonaqueous Fluids Through Downhole Fluid Analysis - A method of monitoring a nonhydrocarbon and nonaqueous fluid injected into the earth's subsurface through a first wellbore that involves positioning a fluid analysis tool within a second wellbore and determining the presence of the injected nonhydrocarbon and nonaqueous fluid by making a measurement downhole on the injected nonhydrocarbon and nonaqueous fluid using the fluid analysis tool. Also a related method of enhancing hydrocarbon production from a subsurface area having first and second wellbores that involves injecting a nonhydrocarbon and nonaqueous fluid into the subsurface through the first wellbore, positioning a fluid analysis tool within the second wellbore, and determining the presence of the injected nonhydrocarbon and nonaqueous fluid by making a measurement downhole on the injected nonhydrocarbon and nonaqueous fluid using the fluid analysis tool. | 05-24-2012 |
Patent application number | Description | Published |
20090006460 | METHOD, SYSTEM, COMPUTER-ACCESSIBLE MEDIUM AND SOFTWARE ARRANGEMENT FOR ORGANIZATION AND ANALYSIS OF MULTIPLE SETS OF DATA - According to exemplary embodiments of the present invention, system, computer-accessible medium and method of organizing or analyzing at least two sets of data can be provided. For example, at least two sets of data may be organized or analyzed by generating a data structure for the at least two sets of the data and comparing the data structure for the at least two sets of the data. The data structure may be in the form of a phylogenetic-type tree. | 01-01-2009 |
20110167031 | METHOD, SYSTEM, AND COMPUTER-ACCESSIBLE MEDIUM FOR INFERRING AND/OR DETERMINING CAUSATION IN TIME COURSE DATA WITH TEMPORAL LOGIC - Time-course data with an underlying causal structure may appear in a variety of domains, including, e.g., neural spike trains, stock price movements, and gene expression levels. Provided and described herein are methods, procedures, systems, and computer-accessible medium for inferring and/or determining causation in time course data based on temporal logic and algorithms for model checking. For example, according to one exemplary embodiment, the exemplary method can include receiving data associated with particular causal relationships, for each causal relationship, determining average characteristics associated with cause and effects of the causal relationships, and identifying the causal relationships that meet predetermined requirement(s) as a function of the average characteristics so as to generate a causal relationship. The exemplary characteristics associated with cause and effects of the causal relationships can include an associated average difference that a cause can make to an effect in relation to each other cause of that effect. | 07-07-2011 |
20130218826 | METHODS, COMPUTER-ACCESIBLE MEDIUM AND SYSTEMS FOR FACILITATING DATA ANALYSIS AND REASONING ABOUT TOKEN/SINGULAR CAUSALITY - Exemplary embodiments of exemplary methods, procedures, computer-accessible medium and systems according to the present disclosure can be provided which can be used for determining token causality. For example, data which comprises token-level time course data and type-level causal relationships can be obtained. In addition, a determination can be made as to whether the type-level causal relationships are instantiated in the token-level time course data, and using a computing arrangement. Further, exemplary significance scores for the causal relationships can be determined based on the determination procedure. It is also possible to determine probabilities associated with the type-level causal relationships using the token-level time course data and a probabilistic temporal model and/or type-level time course data when at least one of the type-level causal relationships have indeterminate truth values. The exemplary determination of the probabilities can be performed using a prior causal information inference procedure. | 08-22-2013 |