| Patent application number | Description | Published |
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| 20090209039 | METHOD AND APPARATUS FOR MICROFLUIDIC INJECTION - A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission direction of the jet or droplet) to produce a jet of liquid from the nozzle. The jet or droplet of liquid may be introduced through a cell membrane and into the cell interior in such a way that damage to the cell membrane that would cause cell death is avoided. An electrode may be formed adjacent a fluid channel by conducting a liquid material, such as solder, from a reservoir and into an electrode portion of an electrode channel to a location adjacent the fluid channel. A passageway between the electrode channel and the fluid channel may prevent flow of the liquid electrode material into the fluid channel during electrode formation. | 08-20-2009 |
| 20090280518 | SYSTEM FOR HIGH THROUGHPUT MEASUREMENT OF MECHANICAL PROPERTIES OF CELLS - A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor system is positioned on the first end side of the cell deforming feature and a second sensor system is positioned on the second end side of the cell deforming feature, and the first and second sensor systems are configured to detect information about a cell as the cell travels across the cell deforming feature. A controller communicating with the first and second sensor systems is adapted to receive data from the first and second sensor systems and calculate a mechanical property of the cell. | 11-12-2009 |
| 20090282978 | Microfluidic Separators for Multiphase Fluid-Flow Based On Membranes - One aspect of the invention relates to fluid-phase separators and devices containing them. Another aspect of the invention relates to the use of said fluid-phase separators and devices containing them for separating individual phases from gas-liquid and liquid-liquid two-phase mixtures for a range of flow regimes. The present invention also relates to methods of making said fluid-phase separators and devices containing them. | 11-19-2009 |
| 20100078597 | HIGHLY LUMINESCENT COLOR-SELECTIVE NANOCRYSTALLINE MATERIALS - A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%. | 04-01-2010 |
| 20100122899 | SMALL-SCALE METHOD AND APPARATUS FOR SEPARATING MIXTURES - The present invention generally relates to the small-scale separation of a mixture of two or more components with different boiling points into enriched fractions. In some embodiments, a first and second fluid (e.g., a liquid and a gas, a liquid and a liquid, etc.) are passed through a channel. The first fluid may comprise at least two components, each with a unique boiling point. Upon contacting the first and second fluids within the channel, at least a portion of the most volatile of the components in the first fluid (i.e., the component with the lowest boiling point) may be transferred from the first fluid to the second fluid. In some instances, the transfer of the volatile component(s) from the first fluid to the second fluid may be expedited by heating, in some cases above the boiling point(s) of the component(s) to be transferred from the first fluid to the second fluid. Contact between the first and second fluids may be maintained, for example, via segmented flow, bubbling flow, etc. In some instances, separation between the first and second fluids may be maintained in a channel that is essentially free of interior microchannel surface irregularities. | 05-20-2010 |
| 20100140585 | QUANTUM DOT WHITE AND COLORED LIGHT-EMITTING DEVICES - A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the QDs themselves, or of a mixture of light emitted from the QDs and light emitted from the primary source. The QDs desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence. | 06-10-2010 |
| 20100141118 | QUANTUM DOT WHITE AND COLORED LIGHT-EMITTING DEVICES - A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the QDs themselves, or of a mixture of light emitted from the QDs and light emitted from the primary source. The QDs desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence. | 06-10-2010 |
| 20100170572 | PUMPING AND FLOW CONTROL IN SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS - The present invention generally relates to devices and methods for affecting the flow rate of fluid using pressure. The invention generally provides for controlled application of pressure to flowing fluids to control pressure and flow rates of those fluids, independent of location of the fluids relative to various devices. For example, in a series of devices, each connected to another via a conduit, pressure control units can be provided between devices to raise or lower pressure and/or flow rate of fluid flowing from one device to the next. In this way, a series of interconnected devices can be arranged such that inlet fluid pressure or flow rate of any individual device can be set independently of every other device. | 07-08-2010 |
| 20100176715 | QUANTUM DOT WHITE AND COLORED LIGHT-EMITTING DEVICES - A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the QDs themselves, or of a mixture of light emitted from the QDs and light emitted from the primary source. The QDs desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence. | 07-15-2010 |
| 20100239833 | Elastomeric mask and use in fabrication of devices - An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique. | 09-23-2010 |
| 20100294986 | SUPERCRITICAL FLUID FACILITATED PARTICLE FORMATION IN MICROFLUIDIC SYSTEMS - The use of supercritical fluids in the production of particles in microfluidic systems is generally described. Small particles with narrow particle size distributions are useful in a wide range of applications. Submicron and micron-sized organic particles may exhibit enhanced properties such as, for example, increased dissolution rates, enhanced pharmaceutical efficacy, and ease of suspension in a carrier medium. Small organic particles may be particularly useful in drug delivery, exhibiting enhanced performance as inhalation aerosols, injectable suspensions, controlled release dosage drugs, transdermally delivered drugs, and the like. | 11-25-2010 |
| 20100298602 | SYSTEMS AND METHODS FOR MICROFLUIDIC CRYSTALLIZATION - Systems and methods for crystallization in microfluidic systems are generally described. Many applications require the collection of time-resolved data to determine advantageous conditions for crystallization. The present invention provides tools and related techniques which address this need, as well as a platform for the growth of crystals within microfluidic channels. The systems and methods described herein provide, in one aspect, tools that allow for controlled, stable crystallization of organic materials in microfluidic channels. The invention can interface not only with microfluidic/microscale equipment, but with macroscale equipment to allow for the easy injection of fluids (e.g., fluids containing crystal precursor), extraction of crystals, determination of one or more crystal properties (e.g., crystal size, size distribution among multiple crystals, morphology, etc.), etc. | 11-25-2010 |
| 20110062025 | ISOELECTRIC FOCUSING SYSTEMS AND METHODS - The invention relates to devices and methods for the separation of species, including biological species and involves the use of free flow isolectric focusing (FF-IEF) devices capable of establishing a pH gradient in a gradient orientation that is perpendicular to the direction of fluid flow. In one embodiment a channel ( | 03-17-2011 |
| 20110118469 | CONTINUOUS FLOW SYNTHESIS OF AMINO ALCOHOLS USING MICROREACTORS - The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency. | 05-19-2011 |
| 20110126914 | SYSTEMS AND METHODS FOR HANDLING SOLIDS IN MICROFLUIDIC SYSTEMS - Systems and methods related to handling solids in microfluidic systems are generally described. Many of the systems and methods described herein address the need to inhibit the formation of blockages in microfluidic channels. | 06-02-2011 |
