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Klass, US

Adam P. Klass, Oak Park, IL US

Patent application numberDescriptionPublished
20090138289METHOD AND SYSTEM FOR IDENTIFYING AND ANTICIPATING ADVERSE DRUG EVENTS - The present invention is a system and method for anticipating potential Adverse Drug Events (ADE) in a patient's medication regimen by integrating data typically located in laboratory and pharmacy information systems and filtering the data using predefined criteria. The present invention includes a system for anticipating a possible ADE through the use of a search engine that compares integrated data from laboratory and pharmacy information systems and compares it to predefined ADE rules defining normal ranges for a particular laboratory test. If an abnormal test value is received and a drug in the patient's medication regimen satisfies a drug included in an ADE rule then an alert procedure is triggered which allows for a period of time wherein the patient's lab and pharmacy data is monitored in order to determine if a proper corrective action is undertaken, and if no corrective action or an improper corrective action is taken within that period of time, the healthcare provider is warned of a potential ADE.05-28-2009

Patent applications by Adam P. Klass, Oak Park, IL US

Charles P. Klass, Redington Beach, FL US

Patent application numberDescriptionPublished
20100203318Use of Aluminum Phosphate, Polyphosphate and Metaphosphate Particles in Paper Coating Applications - Provided herein are coating compositions for paper comprising aluminum phosphate, aluminum metaphosphate, aluminum orthophosphate and/or aluminum polyphosphate pigments. Methods of making and using the compositions are described.08-12-2010

David B. Klass, Westchester, IL US

Patent application numberDescriptionPublished
20090138289METHOD AND SYSTEM FOR IDENTIFYING AND ANTICIPATING ADVERSE DRUG EVENTS - The present invention is a system and method for anticipating potential Adverse Drug Events (ADE) in a patient's medication regimen by integrating data typically located in laboratory and pharmacy information systems and filtering the data using predefined criteria. The present invention includes a system for anticipating a possible ADE through the use of a search engine that compares integrated data from laboratory and pharmacy information systems and compares it to predefined ADE rules defining normal ranges for a particular laboratory test. If an abnormal test value is received and a drug in the patient's medication regimen satisfies a drug included in an ADE rule then an alert procedure is triggered which allows for a period of time wherein the patient's lab and pharmacy data is monitored in order to determine if a proper corrective action is undertaken, and if no corrective action or an improper corrective action is taken within that period of time, the healthcare provider is warned of a potential ADE.05-28-2009

Patent applications by David B. Klass, Westchester, IL US

Edgardo F. Klass, Palo Alto, CA US

Patent application numberDescriptionPublished
20100277219Clock Gater with Test Features and Low Setup Time - A clock gater circuit comprises a plurality of transistors having source-drain connections forming a stack between a first node and a supply node. A given logical state on the first node causes a corresponding logical state on an output clock of the clock gater circuit. In one embodiment, a first transistor of the plurality of transistors has a gate coupled to receive an enable input signal. A second transistor is connected in parallel with the first transistor, and has a gate controlled responsive to a test input signal to ensure that the output clock is generated even if the enable input signal is not in an enabled state. In another embodiment, the plurality of transistors comprises a first transistor having a gate controlled responsive to a clock input of the clock gater circuit and a second transistor having a gate controlled responsive to an output of a delay circuit. The delay circuit comprises at least one inverter, wherein an input of the delay circuit is the clock input, and wherein a first inverter of the delay circuit is coupled to receive a test input signal and is configured to force a first logical state on an output of the first inverter responsive to an assertion of the test input signal.11-04-2010
20100308790APPARATUS AND METHOD FOR TESTING DRIVER WRITEABILITY STRENGTH ON AN INTEGRATED CIRCUIT - An apparatus and method for testing driver write-ability strength on an integrated circuit includes one or more drive detection units each including a number of drivers. At least some of the drivers may have a different drive strength and each may drive a voltage onto a respective driver output line. Each drive detection unit may include a number of keeper circuits, each coupled to a separate output line and configured to retain a given voltage on the output line to which it is coupled. Each detection unit may also include a number of detection circuits coupled to detect the drive voltage on each of the output lines. In one implementation, the drive voltage appearing at the output line of each driver may be indicative of that the driver was able to overdrive the voltage being retained on the output line to which it is coupled by the respective keeper circuits.12-09-2010
20100308887APPARATUS AND METHOD FOR TESTING LEVEL SHIFTER VOLTAGE THRESHOLDS ON AN INTEGRATED CIRCUIT - An apparatus and method for testing level shifter threshold voltages on an integrated circuit includes one or more level shifter modules each including a number of level shifter circuits. Each level shifter circuit may be coupled to a first and a second voltage supply. Each level shifter circuit may also receive an input signal that is referenced to the first voltage supply, and to generate an output signal that is referenced to the second voltage supply. In addition, each level shifter module may include detection logic that may detect an output value of each of the level shifter circuits. The control circuit may be configured to iteratively change the voltage output from one of the voltage supplies, and maintaining a voltage on the other voltage supply while the input signal is provided to the level shifter circuits. The detection logic may capture the output value upon each change in voltage.12-09-2010
20100322026MECHANISM FOR MEASURING READ CURRENT VARIABILITY OF SRAM CELLS - A mechanism for measuring the variability of the read current of SRAM cells on an integrated circuit includes the integrated circuit having an SRAM array including a plurality of SRAM cells. The integrated circuit may also include a selection circuit configured to select a particular SRAM cell in response to a selection input. An oscillator circuit such as a ring oscillator, for example, on the integrated circuit may be configured to oscillate at a frequency that is dependent upon a read current of a selected SRAM cell during operation in a first mode. A frequency determining circuit that is coupled to the oscillator circuit may be configured to output a value corresponding to the frequency of oscillation of the oscillator circuit.12-23-2010
20110012643APPARATUS AND METHOD FOR TESTING SENSE AMPLIFIER THRESHOLDS ON AN INTEGRATED CIRCUIT - An apparatus and method for testing sense amplifier threshold voltages on an integrated circuit includes one or more sense amplifier modules each including a number of sense amplifier circuits, a voltage generator unit, and detection logic. The voltage generator unit may select a differential voltage to supply to at least some of the sense amplifier circuits, and each sense amplifier circuit may be configured to generate an output value that is dependent upon the applied differential voltage in response to receiving an enable signal. The detection logic may detect and capture an output value of each of the sense amplifier circuits. In one implementation, the voltage generator unit may iteratively select a different differential voltage in response to a control input. Accordingly, the detection logic may capture the output value of the sense amplifiers after each change in differential voltage.01-20-2011
20110202809Pulse Flop with Enhanced Scan Implementation - In an embodiment, a clocked storage device such as a pulse flop is provided. The pulse flop includes a latch coupled to receive a scan data input to the pulse flop. The latch receives the scan data input during one of the phases of the clock, and retains the received input during the other phase. The other phase is the phase in which the pulse to the pulse flop occurs. Thus, when scan data is captured in the pulse flop, the latch at the next pulse flop in the chain may be closed and may prevent a race condition in propagating the scan data.08-18-2011

Patent applications by Edgardo F. Klass, Palo Alto, CA US

Edgardo F. Klass, Cupertino, CA US

Patent application numberDescriptionPublished
20110016367SKEW TOLERANT SCANNABLE MASTER/SLAVE FLIP-FLOP INCLUDING EMBEDDED LOGIC - An integrated circuit includes a flip-flop circuit having a master latch unit and a slave latch unit. The master latch unit includes a data latch that may receive a data value on a data input, and a scan latch that may receive a scan data value on a scan data input. The data latch may latch and output the data value on an output line in response to a transition of a first clock signal, while the scan latch may latch and output the scan data value on the output line in response to a transition of a second clock signal. The slave latch unit may latch and output either the data value or the scan data value. The flip-flop circuit also includes a clock select circuit that may selectively provide either the first clock signal or the second clock signal dependent upon a scan enable signal.01-20-2011
20110025394LOW LATENCY SYNCHRONIZER CIRCUIT - A synchronizer circuit includes a master stage and a slave stage. The master stage may include a first master latch coupled to receive a data input signal, and a clock signal. The master stage may also include a second master latch coupled to receive the data input signal, and a delayed version of the clock signal. The master stage may further include a pull-up circuit that may drive an output line of the master stage depending upon an output of each of the first master latch and the second master latch. The slave stage may include a slave latch having an input coupled to the output line of the master stage. The slave stage may provide an output data signal that corresponds to the captured input data signal and is synchronized to the receiving clock signal.02-03-2011

Michael Klass, Oro Valley, AZ US

Patent application numberDescriptionPublished
20100113290METHODS FOR ASSESSING RNA PATTERNS - Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.05-06-2010
20100184046Methods and systems of using exosomes for determining phenotypes - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.07-22-2010
20100203529Methods and systems of using exosomes for determining phenotypes - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.08-12-2010
20110151460METHODS AND SYSTEMS OF USING EXOSOMES FOR DETERMINING PHENOTYPES - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.06-23-2011
20110159506METHODS FOR ASSESSING RNA PATTERNS - Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.06-30-2011

Michael R. Klass, Oro Valley, AZ US

Patent application numberDescriptionPublished
20110237450METHODS AND SYSTEMS OF USING EXOSOMES FOR DETERMINING PHENOTYPES - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.09-29-2011