Patent application number | Description | Published |
20090093538 | Method for treating cancer - The invention relates to a method of treating cancer in a subject, comprising administering to the subject an anti-cancer therapy and a compound that increases the oxidative stress of the cancer cells and activates p38. | 04-09-2009 |
20150056221 | ANTI-PRLR ANTIBODIES AND USES THEREOF - The present invention provides antibodies that bind to prolactin receptor (PRLR) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human PRLR with high affinity. In certain embodiments, the invention includes antibodies that bind PRLR and block prolactin-mediated cell signaling. In other embodiments, the invention includes antibodies that bind PRLR but do not block prolactin-mediated cell signaling. The antibodies of the invention may be fully human antibodies. The invention includes anti-PRLR antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers as well as other PRLR-related disorders. The present invention also includes antibody drug conjugates comprising an antibody or antigen-binding fragment thereof that specifically binds a class I cytokine receptor, wherein the antibody or antigen-binding fragment thereof is conjugated to a cytotoxic agent. | 02-26-2015 |
20150056222 | ANTI-PRLR ANTIBODIES AND USES THEREOF - The present invention provides antibodies that bind to prolactin receptor (PRLR) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human PRLR with high affinity. In certain embodiments, the invention includes antibodies that bind PRLR and block prolactin-mediated cell signaling. In other embodiments, the invention includes antibodies that bind PRLR but do not block prolactin-mediated cell signaling. According to certain embodiments, the invention includes antibodies that bind to the first fibronectin-like type III domain of the extracellular domain of PRLR. The antibodies of the invention may be fully human antibodies. The invention includes anti-PRLR antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers as well as other PRLR-related disorders. The present invention also includes antibody drug conjugates comprising an antibody or antigen-binding fragment thereof that specifically binds a class I cytokine receptor, wherein the antibody or antigen-binding fragment thereof is conjugated to a cytotoxic agent. | 02-26-2015 |
Patent application number | Description | Published |
20080198970 | COMPACT SCANNED ELECTRON-BEAM X-RAY SOURCE - A compact, reliable scanning electron-beam x-ray source achieves reduced complexity and cost. In particular, the x-ray source includes an electron beam that is propagated parallel to an x-ray target and is swept across the target in response to a moving magnetic cross field. Rather than scanning the beam by deflecting it about a single point, the point of deflection is translated along the target length, dramatically reducing the volume of the device. The magnetic cross field is translated along the target length using either mechanical systems to move permanent magnets, or electrical systems to energize an array of electromagnets. | 08-21-2008 |
20080258624 | BOWTIE DEFLECTOR CAVITY FOR A LINEAR BEAM DEVICE - A resonant cavity with a bowtie shape supports an electromagnetic field used to deflect the trajectory of an electron beam passing through the cavity. The short transit time of the beam across the gap maintains the cavity fields at near-optimal phase, improving interaction efficiency even for relatively low-energy beams. High interaction impedance ensures good drive-power-to-deflection conversion efficiency. The uniform field achieved across the gap enforces uniform deflection across the beam profile to maintain beam quality. Multiple bowtie cavities can be arranged to allow arbitrary two-dimensional deflections. | 10-23-2008 |
20080258625 | METHOD AND APPARATUS FOR INTERACTION WITH A MODULATED OFF-AXIS ELECTRON BEAM - An output circuit for a microwave tube is provided that has generally high interaction impedance for good efficiency, has high average power capability, and is physically large for a given operating frequency. The output circuit is designed to operate in conjunction with an off-axis, bunched electron beam. Electromagnetic fields are applied to the region in which the electron beam propagates to impart an azimuthal velocity to the bunched electron beam. The electron bunches then interact synchronously with a resonant output structure to excite radio-frequency modes from which energy can be extracted and applied to a load. | 10-23-2008 |
20110050096 | ACTIVE ELECTRONICALLY STEERED CATHODE EMISSION - An active electronically steered cathode (AESC) applies one or more electromagnetic modes to an input cavity, similar to that used in an inductive output tube. The structure and superposition of these modes creates local electric field maxima, causing the electron emission site or sites to move or be distributed across the surface of the cathode. Changing the amplitude, phase, or frequency of the modes provides time-variable control of the electric field profile, thereby generating electronically steered electron beams. One embodiment employs a pair of orthogonal TM modes driven out of phase, causing the electric field maximum to rotate around an annular cathode, producing a helical beam. Slots in the control grid may be used to segment the helical beam into discrete bunches to provide additional density modulation. | 03-03-2011 |
20110050097 | HYBRID MODULATION IN AN EMISSION-GATED ELECTRON GUN - An apparatus and method of modulating an electron beam to induce a high degree of spatial bunching uses multiple control grids located in close proximity to an electron-emitting cathode. An RF field couples to the electron beam in the cathode-grid gap to induce velocity modulation. The electron beam then propagates through a first control grid, allowing the velocity modulation to induce spatial bunching. The electron beam then traverses a gap between the first grid and a second control grid and interacts with the RF field to induce further bunching of the beam. Simulations show that bunching factors of 50:1 may be achieved. | 03-03-2011 |
20110064414 | OVERMODED DISTRIBUTED INTERACTION NETWORK - An overmoded distributed interaction network is provided that generates high peak and average RF power amplification at high frequencies. A series of overmoded cavities are bounded by parallel or concentric grids that may be separated by metallic spacers adapted to function as a photonic bandgap circuit to suppress competing electromagnetic modes. The selected electromagnetic modes have wavelengths much shorter than the lateral dimension of the grids, allowing the beam-wave interaction to be distributed transversely for improved interaction efficiency. The grids may optionally be slotted and arranged to provide a serpentine traveling wave tube configuration. | 03-17-2011 |