Patent application number | Description | Published |
20090305343 | Method For Expressing Polypeptides In Eukaryotic Cells Using Alternative Splicing - This invention relates to an expression cassette for expressing polypeptides in eukaryotic cells using alternative splicing. The expression cassette comprises in 5′ to 3′ downstream direction: a promoter; a sequence transcribed in a 5′ untranslated region (5′UTR); a donor splice site; an intron; a first acceptor splice site; a first cistron encoding a first polypeptide; a second acceptor splice site; a second cistron encoding a second polypeptide; an internal ribosome entry site (IRES) operably linked to a selection marker; and a sequence transcribed in a 3″ untranslated region (3′UTR) including a polyadenylation signal, wherein the polyadenylation signal is unique. | 12-10-2009 |
20090318308 | HIGHLY DIVERSIFIED ANTIBODY LIBRARIES - The present invention provides an in vitro method for obtaining a library of polynucleotides encoding antibodies, derivatives thereof or fragments thereof, comprising the step of performing random mutagenesis of a polynucleotide encoding the variable region of a heavy chain and/or the variable region of a light chain of a light chain, wherein random mutagenesis is performed on a library of polynucleotides comprising a sequence encoding the variable region of a heavy chain and/or the variable region of a light chain; and wherein the random mutagenesis process creates randomly distributed mutations along at least 70% of the sequence encoding the variable region. | 12-24-2009 |
20120009188 | OPTIMIZED FC VARIANTS - A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region. | 01-12-2012 |
20140141019 | ANTIBODIES AGAINST HER3 - The invention relates to antibodies against HER3 and their use in the treatment of cancer. | 05-22-2014 |
20140378663 | FC VARIANTS WITH REDUCED EFFECTOR FUNCTIONS - A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide. | 12-25-2014 |
Patent application number | Description | Published |
20090066330 | NMR MEASUREMENT OF WAX APPEARANCE IN FLUIDS - A method for determining a wax appearance temperature of a fluid includes obtaining nuclear magnetic resonance (NMR) measurements of the fluid at a plurality of temperatures; deriving a NMR parameter from each of the NMR measurements; and determining the wax appearance temperature by analyzing the NMR parameter as a function of temperature. An apparatus for detecting wax appearance in a fluid includes a sample cell for holding a fluid for nuclear magnetic resonance (NMR) measurements at a plurality of temperatures; a temperature measuring device disposed proximate the sample cell; a magnet for polarizing molecules in the fluid in the sample cell; at least one radiofrequency (RF) coil for generating pulses of magnetic field and for detecting NMR signals; and circuitry for controlling and measuring the temperature of the fluid in the sample cell and for obtaining NMR measurements. | 03-12-2009 |
20090248310 | METHODS AND APPARATUS FOR ANALYSIS OF DOWNHOLE ASPHALTENE GRADIENTS AND APPLICATIONS THEREOF - A method and system for characterizing asphaltene gradients of a reservoir of interest and analyzing properties of the reservoir of interest based upon such asphaltene gradients. The analysis employs a correlation that relates insoluble asphaltene concentration to spectrophotometry measurement data measured at depth. | 10-01-2009 |
20100033176 | METHODS FOR DETERMINING IN SITU THE VISCOSITY OF HEAVY OIL - Viscosity of heavy oil is determined in situ in a formation by making nuclear magnetic resonance (NMR) measurements in the formation, and then calculating viscosity according to an equation of the form | 02-11-2010 |
20100039109 | METHODS FOR DETERMINING IN SITU THE VISCOSITY OF HEAVY OIL USING NUCLEAR MAGNETIC RESONANCE RELAXATION TIME MEASUREMENTS - The viscosity η (in centipoise) of a heavy oil sample is determined according to an equation of the form ln | 02-18-2010 |
20100043538 | METHODS OF AND APPARATUS FOR DETERMINING THE VISCOSITY OF HEAVY OIL - The viscosity of a heavy oil is estimated according to a power law equation which relates the heavy oil viscosity to a function of the assumed, measured, or estimated glass transition temperature of the heavy oil and the measured temperature of the heavy oil. | 02-25-2010 |
20110292382 | SYSTEM AND METHOD FOR DETERMINING THE ASPHALTENE CONTENT OF CRUDE OIL - A system for determining the asphaltene content of crude oil includes a first optical flow cell, a first spectrometer operably associated with the first optical flow cell, and a mixer in fluid communication with the first optical flow cell. The system further includes a crude oil injection/metering device configured to receive the crude oil, the crude oil injection/metering device being in fluid communication with the first optical flow cell; a titrant injection/metering device in fluid communication with the mixer, the titrant injection/metering device configured to receive a titrant; and a filtration unit in fluid communication with the mixer. The system further includes a second optical flow cell in fluid communication with the filtration unit, and a second spectrometer operably associated with the second optical flow cell. | 12-01-2011 |
20130188169 | APPARATUS AND METHODS FOR DETERMINING COMMINGLING COMPATIBILITY OF FLUIDS FROM DIFFERENT FORMATION ZONES - An apparatus and a method including exposing a first fluid to a pre-filter, observing the first fluid, introducing a second fluid to the first fluid, exposing the first and second fluids to a filter, and observing the first and second fluids wherein the observing the first fluid and observing the first and second fluids comprise optical measurements and the first fluid comprises material from a subterranean formation. Some embodiments may compare the optical measurements of the first fluid and the first and second fluids and/or estimate the first fluid's likelihood of forming precipitants with other fluids and/or the first fluid's asphaltene content. An apparatus and method for characterizing a fluid property including a pre-filter in communication with a fluid from a formation, an optical sensor to observe the fluid from the pre-filter, a fluid combination device in communication with the fluid and a second fluid source, a filter in communication with the combination device, a second optical sensor to observe a third fluid from the filter, and a processor to compare data collected by the sensor and second sensor. | 07-25-2013 |
20130242288 | Method For Measuring Fractions Of Hydrocarbon Fluids Using Optical Spectroscopy - A method for measuring saturate, aromatic, and resin fractions of a hydrocarbon fluid includes separating maltenes from the hydrocarbon fluid and separating saturate, aromatic, and resin fractions from the maltenes. The method further includes determining an optical density of each of the saturate, aromatic, and resin fractions at a predetermined wavelength and correlating the optical density of each of the saturate, aromatic, and resin fractions to predetermined data to determine each of the saturate, aromatic, and resin fractions. | 09-19-2013 |
20140369889 | Apparatus and System for Measuring Asphaltene Content of Crude Oil - A system for measuring asphaltene content of crude oil, includes a microfluidic chip, the microfluidic chip having a crude oil sample inlet port, a solvent port, a mixer and reactor section in fluid communication with the crude oil sample inlet port and the solvent port, and a filter in fluid communication with the mixer and reactor section, the filter having an inlet side and an outlet side, a waste port in fluid communication with the inlet side of the filter, and a product port in fluid communication with the outlet side of the filter. The system further includes an optical cell in fluid communication with the product port. | 12-18-2014 |
20140375991 | Method and Apparatus for Determining Asphaltene Yield and Flocculation Point of Crude Oil - A method for determining an asphaltene yield curve and an asphaltene flocculation point includes obtaining a crude oil sample and measuring an optical spectrum of the crude oil sample. A titrant is then mixed with the crude oil sample at different concentrations. At each concentration, precipitated asphaltenes are filtered from the mixture and the optical spectrum of the filtrate is measured. The optical spectrum of the filtrate is then subtracted from the optical spectrum of the crude oil sample. A fractional asphaltene precipitation is determined for each concentration of titrant. A flocculation point is determined corresponding to an inflection point in the fractional asphaltene precipitation for each concentration of titrant. | 12-25-2014 |
20150036136 | System and Method for Characterizing Crude Oil Fractions - A system for characterizing crude oil fractions includes a maltenes sample reservoir, a first solvent reservoir, a second solvent reservoir, and a third solvent reservoir. The system further includes a valve in fluid communication with the first solvent reservoir, the second solvent reservoir, and the third solvent reservoir and a pump in fluid communication with the valve. The system further includes a packed bed in fluid communication with the maltenes sample reservoir and the pump, a flowthrough cell in fluid communication with the packed bed, a spectrometer operably associated with the flowthrough cell, and a computer operably associated with the spectrometer. A method for characterizing crude oil fractions includes providing a maltene sample, eluting saturates, aromatics, and resins of the maltene sample, determining an optical density of each, and determining a concentration of each of the saturates, aromatics, and resins based upon optical densities over time for each. | 02-05-2015 |
20150209781 | APPARATUS AND SYSTEM FOR MEASURING ASPHALTENE CONTENT OF CRUDE OIL - A system for measuring asphaltene content of crude oil, includes a microfluidic chip, the microfluidic chip having a crude oil sample inlet port, a solvent port, a mixer and reactor section in fluid communication with the crude oil sample inlet port and the solvent port, and a filter in fluid communication with the mixer and reactor section, the filter having an inlet side and an outlet side, a waste port in fluid communication with the inlet side of the filter, and a product port in fluid communication with the outlet side of the filter. The system further includes an optical cell in fluid communication with the product port. | 07-30-2015 |
20150209782 | APPARATUS AND SYSTEM FOR MEASURING ASPHALTENE CONTENT OF CRUDE OIL - A system for measuring asphaltene content of crude oil, includes a microfluidic chip, the microfluidic chip having a crude oil sample inlet port, a solvent port, a mixer and reactor section in fluid communication with the crude oil sample inlet port and the solvent port, and a filter in fluid communication with the mixer and reactor section, the filter having an inlet side and an outlet side, a waste port in fluid communication with the inlet side of the filter, and a product port in fluid communication with the outlet side of the filter. The system further includes an optical cell in fluid communication with the product port. | 07-30-2015 |