Patent application number | Description | Published |
20100330644 | BOUNDARY CONDITIONS FOR THE ARRANGEMENT OF CELLS AND TISSUES - The present invention relates to the arrangement of one or more cells in a medium or on a substrate through the use of boundary conditions, which are changes in local environment compared to the medium or substrate alone or cause an alteration of cell response upon interaction of a cell with the boundary condition. | 12-30-2010 |
20120027807 | TISSUE ENGINEERED MYOCARDIUM AND METHODS OF PRODUCTION AND USES THEREOF - The present invention generally relates to a population of committed ventricular progenitor (CVP) cells and their use to generate a tissue engineered myocardium, in particular two dimensional tissue engineered myocardium which is comparable to functional ventricular heart muscle. One embodiment of present invention provides a composition and methods for the production of a tissue engineered myocardium which has functional properties of cardiac muscle, such as contractibility (e.g. contraction force) and numerous properties of mature fully functional ventricular heart muscle tissue. In particular, in one embodiment, a composition comprising the tissue engineered myocardium comprises committed ventricular progenitor (CVP) cells seeded on a free-standing biopolymer structure to form functional ventricular myocardium tissue. | 02-02-2012 |
20120029416 | POROUS ELECTROACTIVE HYDROGELS AND USES THEREOF - The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels. | 02-02-2012 |
20120135448 | METHODS AND DEVICES FOR THE FABRICATION OF 3D POLYMERIC FIBERS - The present invention provides methods and devices for the fabrication of 3D polymeric fibers having micron, sub-micron, and nanometer dimensions, as well as methods of use of these polymeric fibers. | 05-31-2012 |
20120142556 | HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays. | 06-07-2012 |
20130037419 | ELECTROMECHANICAL SYSTEMS INCLUDING BIOCHEMICAL ACTUATOR HEADS - Disclosed herein are biochemical actuator heads instrumented with a receptor conductive polymer for reversibly controlling ligand-receptor interactions. Also disclosed are systems and methods for utilizing and fabricating the biochemical actuator head. The biochemical actuator head and related systems and methods may be used in a wide array of applications including, without limitation, micro/nano assembly, examination of cellular signaling mechanisms, image-guided cell nanosurgery or particle processing. Particle processing systems and methods are also provided utilizing a receptor conductive polymer for reversibly controlling ligand-receptor interactions. | 02-14-2013 |
20130046134 | METHODS OF GENERATING ENGINEERED INNERVATED TISSUE AND USES THEREOF - The present invention provides methods for generating relevant in vitro models of engineered innervated tissue, as well as uses of such tissues. | 02-21-2013 |
20130312638 | SYSTEMS, DEVICES AND METHODS FOR THE FABRICATION OF POLYMERIC FIBERS - Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron, and nanometer dimensions, as well as methods of use of the polymeric fibers. | 11-28-2013 |
20130330378 | ANISOTROPIC BIOLOGICAL PACEMAKERS AND AV BYPASSES - The present invention provides biological pacemakers or AV-node bypasses The biological pacemakers or AV-node bypasses of the invention are useful for the treatment of, inter alia, cardiac arrhythmias and AV-node conduction defects. | 12-12-2013 |
20140236267 | PHOTOSENSITIVE CARDIAC RHYTHM MODULATION SYSTEMS - Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies. | 08-21-2014 |
20140322515 | SYSTEMS, DEVICES AND METHODS FOR FABRICATION OF POLYMERIC FIBERS - In accordance with an exemplary embodiment, a method is provided for forming a micron, submicron and/or nanometer dimension polymeric fiber. The method includes providing a stationary deposit of a polymer. The method also includes contacting a surface of the polymer to impart sufficient force in order to decouple a portion of the polymer from the contact and to fling the portion of the polymer away from the contact and from the deposit of the polymer, thereby forming a micron, submicron and/or nano-meter dimension polymeric fiber. | 10-30-2014 |
20140342394 | MUSCLE CHIPS AND METHODS OF USE THEREOF - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays. | 11-20-2014 |
20140342445 | ORGAN CHIPS AND USES THEREOF - Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies. | 11-20-2014 |