Kesner
Adam Kesner, Los Angeles, CA US
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20080273785 | Methods and systems for retrospective internal gating - The present invention, in one form, is a method for deriving respiratory gated PET image reconstruction from raw PET data. In reconstructing the respiratory gated images in accordance with the present invention, respiratory motion information derived from individual voxel signal fluctuations, is used in combination to create usable respiratory phase information. Employing this method allows the respiratory gated PET images to be reconstructed from PET data with out the use of external hardware, and in a fully automated manner. | 11-06-2008 |
Adam Leon Kesner US
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20160019679 | MEDICAL IMAGING - A method of providing a medical image of a region of interest (ROI) of a patient, the method comprising: acquiring a time ordered sequence of measurements of radiation used to provide the medical image; generating a Fourier transform of the time ordered sequence or a function thereof; using the Fourier transform to determine which of the frequencies characterize real motion of tissue in the ROI and which characterize noise; generating a corrected Fourier transform that is exclusive of frequencies that characterize noise; and providing a medical image of the ROI using the corrected Fourier transform. | 01-21-2016 |
Barry Kesner, Charlestown, MA US
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20150225717 | Selective Reactivation of Genes on the Inactive X Chromosome - Methods and compositions for selectively reactivating genes on the inactive X chromosome (Xi) in a locus-specific manner, e.g., genes associated with X-linked diseases, e.g., Rett Syndrome, Factor VIII or IX deficiency, Fragile X Syndrome, Duchenne muscular dystrophy, and PNH, in heterozygous females. | 08-13-2015 |
20150376612 | CCCTC-Binding Factor (CTCF) RNA Interactome - This invention relates to methods and compositions for selectively reactivating or downregulating certain genes, e.g., genes regulated by zinc-finger protein CCCTC-binding factor (CTCF) on autosomes (e.g., imprinted genes, tumor suppressors, cancer) and the inactive X chromosome (Xi), e.g., genes associated with X-linked diseases, e.g., Rett Syndrome, Factor VIII or IX deficiency, Fragile X Syndrome, Duchenne muscular dystrophy, and PNH, in heterozygous females carrying a mutated allele, in addition to a functional wildtype or hypomorphic allele. | 12-31-2015 |
Craig A. Kesner, Keyser, WV US
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20110019711 | Portable Laser Source - A portable laser source includes a flash lamp assembly defining a hollow central channel, an elongate laser rod extending within the hollow channel for receiving a flash of light emitted by the surrounding flash lamp assembly, and a hermetically-sealed enclosure housing both the flash lamp assembly and the laser rod and including at least one optical transmission window for transmitting a laser beam emitted by the laser rod. Preferably, the flash lamp assembly is hermetically-sealed from the laser rod within the enclosure to maintain physical and electrical isolation of the laser rod from combustible and electrically conductive components of the flash lamp assembly. The combustible component of the flash lamp assembly can include Zr wool and an accelerant, or like materials for emitting a flash of light. The laser source can include a second window used to test the condition of the laser rod via application of an external test light to activate the laser rod within the sealed enclosure. | 01-27-2011 |
Ed Kesner, Mesa, AZ US
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20090314364 | PRESSURE RELIEF VALVES AND PNEUMATIC CONTROL SYSTEMS - A pressure relief valve includes a lever plate, a first spring, a fitting, and a guide assembly. The fitting has a first side, a second side, and a flange having a rounded end and includes a surface with which a first end of the first spring contacts. The guide assembly has two sides, two concavities, and at least a portion of the guide assembly extends through the opening of the lever plate, the first concavity is formed on the first side of the guide assembly and contacts the fitting flange rounded end, and the second concavity is aligned coaxially with the first concavity. A rounded end of a rod of the diaphragm assembly contacts the second concavity. The second spring is adapted to supply a second force against the diaphragm assembly to move the lever plate in a second direction that is substantially opposite the first direction. | 12-24-2009 |
20110155939 | BUTTERFLY VALVE ASSEMBLY INCORPORATING A UNITARY SHAFT AND BUTTERFLY PLATE VALVE ELEMENT - A butterfly valve assembly includes a unitary flow body and a unitary valve element. The unitary valve element is rotationally mounted within the flow body and includes a rotationally mounted shaft and a butterfly plate that is formed integral to the shaft. The butterfly valve assembly can withstand the maximum drive torque supplied from an associated actuator, while at the same time meeting a desired level of flow performance, and allows the unitary valve element to be installed up through the pilot bore. | 06-30-2011 |
20120056115 | FLUID ACTUATED VALVE WITH HALL POSITION SENSOR - A valve actuator includes an actuator housing, a piston, a linkage assembly, a magnet, and a Hall sensor. The actuator housing is adapted to receive pressurized fluid. The piston is movably mounted within actuator housing, and is configured to translate in a first direction and a second direction. The linkage assembly is rotationally coupled to the piston and is adapted to couple to a valve element. The linkage assembly is configured to rotate the valve element in a first rotational direction and a second rotational direction in response to piston movement in the first direction and the second direction, respectively. The magnet is mounted on the piston and is movable therewith, and the Hall sensor is mounted on the actuator housing and is responsive to movement of the magnet to supply a position signal. | 03-08-2012 |
Joshua Brandon Kesner, Brooklyn, NY US
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20130284630 | CASES FORMED FROM BOOKS - An effective, physically protective case for small electronic devices is made from repurposed books. The case may conceal the device to make it appear as a less valuable item. The case, being made from old, repurposed books, makes use of items that may otherwise be disposed of, thereby preventing waste. By using an actual book, rather than trying to replicate the look of a book, the case can effectively conceal ebooks, tablet computers, smart phones, and the like, even under the closest inspection. The case is sturdy, has few moving parts, is durable and is produces using only recycled materials. | 10-31-2013 |
Leo Kesner, West Orange, NJ US
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20080200399 | Compounds for Treating Neurologic Diseases, Otologic Diseases, or Ophthalmologic Diseases and Methods of Use Thereof - Described herein are compounds and methods for treating or preventing a neurologie, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics. | 08-21-2008 |
20120135915 | TREATMENT OF TRAUMATIC OR DEGENERATIVE NEUROLOGIC, OTOLOGIC, OR OPHTHALMOLOGIC DISEASES WITH TARGETED PROTEASE INHIBITORS - Described herein are compounds and methods for treating or preventing a neurologic, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics. | 05-31-2012 |
Raymond Pierre Kesner, Salt Lake City, UT US
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20130210829 | APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME - Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT | 08-15-2013 |
20150209353 | APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME - Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT | 07-30-2015 |
Samuel Kesner, Somerville, MA US
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20130190726 | MOTION COMPENSATING CATHETER DEVICE - A catheter system allows for percutaneous intervention on the fast-moving structures inside the heart. The device consists of a steerable catheter sheath, an actuated, multi-degree of freedom moving catheter, and a catheter end effector, such as a fixation device. An actuator controls the motion of the catheter guide-wire in the catheter sheath to follow the motion of the target tissue. A control system controls the actuator and compensates for mechanical characteristics of the system including friction and backlash. A 3-D imaging system can be used to view the motion of the target tissue and the catheter end effector and produce 3-D imaging data. The 3-D imaging data can be used by the control system to track the target tissue and accurately position the end effector with respect to the moving target tissue allowing a clinician to repair the target tissue while it is moving. The system can be used to perform mitral valve annuloplasty wherein the actuated catheter compensates for the heart valve motion and an end effector fixation device is used to place fixation items, like anchors or staples, into the heart valve tissue to fix the annulus. | 07-25-2013 |
Samuel Kesner, Needham, MA US
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20100217299 | SURGICAL REMOVAL OF INTERNAL TISSUE - Methods and devices are provided for macerating and removing tissue. In general, a maceration device is provided that can be distally advanced into a body in a minimally invasive surgical procedure and positioned proximate to tissue desirable for removal from the body. The maceration device can include an elongate shaft having a cutting element positioned on the shaft's side (i.e., not located on a distal tip of the elongate shaft). The cutting element can rotate to macerate tissue. When being introduced to the body, an elongate axis of the elongate shaft and a longitudinal axis of the cutting element can be substantially parallel to each other. When the cutting element rotates, the elongate axis of the elongate shaft and longitudinal axis of the cutting element can not be parallel during at least a portion of the cutting element's rotation. | 08-26-2010 |
Samuel Benjamin Kesner, Arlington, MA US
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20140239600 | METHODS AND DEVICES FOR SAFELY PENETRATING MATERIALS - The present invention is directed to a bi-stable coupling for controlling the depth of a tool insertion, such as drilling, and similar processes. The bi-stable coupling can be used to penetrate (e.g., drill or push) through a material layer of unknown thickness without plunging the tool into the adjacent layer. In accordance with the invention, in a first state, force is applied to the tool to initiate penetration and a reactive force maintains the device in the first state during penetration and when tool penetrates the material, the reactive force is diminished enabling the device to transition to a second state in which the tool becomes retracted. In medical applications, the invention allows for drilling through bone of unknown thickness without plunging into the adjacent soft tissue. | 08-28-2014 |