Kesavan
Kesavan Balakumaran, Andhra Pradesh IN
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20130281662 | PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES - The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degareiix itself. The manufacturing process comprises the step of cleaving the ε-amino protecting group Pε from a Degareiix precursor according to formula {P | 10-24-2013 |
Kesavan Esuvaranathan, Singapore SG
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20090054364 | Methods and compositions for delivery of pharmaceutical agents - Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a solubilized cholesterol composition is used to facilitate delivery of pharmaceutical agents. Preferably, the cholesterol is solubilized by a cyclodextrin (e.g., methyl-β-cyclodextrin) and the pharmaceutical agent comprises a polynucleotide and either a cationic lipid, a cationic polymer or a dendrimer. Improved methods for transfecting polynucleotides into cells thus are also provided, using cationic lipids, cationic polymers or dendrimers and solubilized cholesterol, wherein the transfection efficiency is enhanced compared to use of cationic lipids, cationic polymers or dendrimers alone. Preferred methods of the invention involve transfecting polynucleotides into urothelial cells, preferably for therapeutic treatment of bladder cancer using, for example, a polynucleotide(s) encoding an interleukin(s), an interferon(s), a colony stimulating factor(s) and/or a tumor suppressor(s). | 02-26-2009 |
Kesavan Srikumar, Cupertino, CA US
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20090038420 | Rack System and a Method for Processing Manufactured Products - A rack system and method are provided for processing manufactured products prior to shipment. To simulate reality, the design of such rack system and method contemplates replicating field conditions for use of the manufactured products. A rack system for processing units of manufactured products may comprise one or more plates coupled to a frame. A preferred approach includes designing the rack for use by an operator without specialized skills. This approach includes verifying that there is a match between the configuration of the unit mounted on the plate and the operating mode of the plate before processing can commence. The rack may include a detector for obtaining data from the plate and unit and a processor for comparing the obtained data to determine whether there is a match. A rack system designed using this approach can be useful in processing outdoor units of a split-mount system such as a microwave radio system. | 02-12-2009 |
20120029680 | INTELLIGENT PRODUCTION STATION AND PRODUCTION METHOD - One aspect related to design of systems and methods for manufacturing products that include technology in skilled areas is configuring a production station for use by an operator without specialized skills. The present invention contemplates an approach to designing a station configurable to perform one or more of incoming inspection, assembly, testing, and branding. A preferred approach includes verifying data associated with units prior to accepting them for incorporation, preventing incorporation of an incorrect unit, and guiding an operator in possible remedial action. This approach includes storing data in a server and making such data substantially instantly accessible to production stations once written in the server. Such data preferably includes software to configure the production station such that the operator need not have specialized skills. A production station designed using this approach is particularly useful in the manufacture of an outdoor unit of a split-mount microwave radio system. | 02-02-2012 |
Kesavan Srinivasan, Hudson, OH US
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20090259999 | METHOD AND SYSTEM FOR APPLYING A PATCH DURING APPLICATION EXECUTION - Some embodiments of the present invention provide a system that applies a patch to an application during execution of the application. During operation, the system obtains source code for the patch and constructs a shared library from the source code. Next, the system dynamically loads the shared library into the application. Finally, the system replaces an old version of a function in the application with a new version of the function from the shared library, which changes the execution of the application in accordance with the patch. | 10-15-2009 |
Kesavan Thiruvenkatasamy, Sunnyvale, CA US
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20100054246 | CONVERGENCE OF MULTICAST TRAFFIC - A multicast data packet sent from a source node is received by a transit node. The multicast data packet includes a source address and a multicast group address. A hardware cache miss is detected at the transit node for the multicast data packet. The multicast data packet is hardware-flooded onto ports of the network. The flooding consists of forwarding a copy of the multicast data packet to neighbor nodes of the transit node based on virtual local area network (VLAN) membership. A cache-miss copy of the multicast data packet is sent to an out-of-line processing unit where it is processed in software. The processing includes establishing, via a hardware abstraction layer, a hardware cache entry for the multicast data packet. The cache-miss copy is not forwarded onto the network. | 03-04-2010 |