Patent application number | Description | Published |
20090318838 | Neoplastic cell destruction device and method utilizing low frequency sound waves to disrupt or displace cellular materials - A neoplasm cell destruction device utilizing low frequency sound waves to disrupt or displace cellular materials in neoplastic cells so as to damage and ultimately destruct the neoplastic cells. The device includes a plurality of signal generators, a controller, a plurality of amplifiers, a plurality of transducers, and a target interface. The controller is in electrical communication with, and generates timing and control signals for simultaneously activating, the plurality of signal generators. Each amplifier is in electrical communication with a respective signal generator and amplifies the signal generated by the respective signal generator so as to form an amplified signal. Each transducer is in electrical communication with a respective amplifier and is driven by the amplified signal formed by the respective amplifier. The target interface combines the waveforms formed by the plurality of transducers to form an interference wave that is a low frequency sound wave. | 12-24-2009 |
20090318839 | Neoplastic cell destruction device and method utilizing low frequency sound waves to disrupt or displace cellular materials - A neoplasm cell destruction device utilizing low frequency sound waves to disrupt or displace cellular materials in neoplastic cells so as to damage and ultimately destruct the neoplastic cells. The device includes a plurality of signal generators, a controller, a plurality of amplifiers, a plurality of transducers, and a target interface. The controller is in electrical communication with, and generates timing and control signals for simultaneously activating, the plurality of signal generators. Each amplifier is in electrical communication with a respective signal generator and amplifies the signal generated by the respective signal generator so as to form an amplified signal. Each transducer is in electrical communication with a respective amplifier and is driven by the amplified signal formed by the respective amplifier. The target interface combines the waveforms formed by the plurality of transducers to form an interference wave that is a low frequency sound wave. | 12-24-2009 |
20090318840 | Neoplastic cell destruction device and method utilizing low frequency sound waves to disrupt or displace cellular materials - A neoplasm cell destruction device utilizing low frequency sound waves to disrupt or displace cellular materials in neoplastic cells so as to damage and ultimately destruct the neoplastic cells. The device includes a plurality of signal generators, a controller, a plurality of amplifiers, a plurality of transducers, and a target interface. The controller is in electrical communication with, and generates timing and control signals for simultaneously activating, the plurality of signal generators. Each amplifier is in electrical communication with a respective signal generator and amplifies the signal generated by the respective signal generator so as to form an amplified signal. Each transducer is in electrical communication with a respective amplifier and is driven by the amplified signal formed by the respective amplifier. The target interface combines the waveforms formed by the plurality of transducers to form an interference wave that is a low frequency sound wave. | 12-24-2009 |
Patent application number | Description | Published |
20140181263 | Intelligent Generation and Distribution of an Encoded Content Transport Stream According to Metadata - There is provided a method and system for generating and distributing an encoded content transport stream. The method comprises obtaining metadata and at least one unique identifier that identifies content elements, generating a recipient specific list using the metadata and at least one of the unique identifiers, creating a content transport stream using the recipient specific list including the metadata and the identified content elements, encoding the content transport stream to generate the encoded content transport stream, and distributing the encoded content transport stream through at least one network path. The metadata may include destination points and priority information of the encoded content transport stream, which may take the form of sections of television programming or block of commercial advertisements. | 06-26-2014 |
20140317666 | Recipient Specific Lists for Distribution of Media Content - There is provided a system and method of recipient specific lists for distribution of media content. The method comprises obtaining at least one unique identifier (UID), wherein the at least one UID identifies a content, and wherein the at least one UID identifies a recipient location and presentation data, generating a recipient specific list (RSL) using the at least one UID, wherein the RSL includes at least one content identifier, and wherein the RSL includes at least one recipient identifier, and transmitting the RSL to an encoded content transport stream creator for creation of an encoded content transport stream. The at least one recipient identifier may correspond to a broadcast affiliate television recipient or a multichannel video programming distributor. Additionally, the RSL may contain primary content, such as television programs, movies, commercials, and promotional programming, as well as secondary content, such as content overlays, program schedules, and triggers. | 10-23-2014 |
Patent application number | Description | Published |
20110065359 | CONCEALED AND DISCREET SECURITY POCKET - This discrete, easily accessible, and selectively introduced and selectively removed pocket holds, e.g., keys, cash, credit cards, metro cards, cosmetics, valuables, or other accessories. The pocket is worn in the interior of a brassiere cup or bathing suit top to provide convenience and safety and is shaped and contoured appropriately to the interior of such garment. The pocket can be used with any brassiere and is held in place with a plurality of attaching members, including but not limited to magnets. The pocket is alternately and easily removed from an article of clothing, even in public, and worn as a sachet around the wrist. | 03-17-2011 |
20120329366 | CONCEALED AND DISCREET SECURITY POCKET - This discrete, easily accessible, and selectively introduced and selectively removed pocket holds, e.g., keys, cash, credit cards, metro cards, cosmetics, valuables, or other accessories. The pocket is worn in the interior of a brassiere cup or bathing suit top to provide convenience and safety and is shaped and contoured appropriately to the interior of such garment. The pocket can be used with any brassiere and is held in place with a plurality of attaching members, including but not limited to magnets. The pocket is alternately and easily removed from an article of clothing, even in public, and worn as a sachet around the wrist. | 12-27-2012 |
Patent application number | Description | Published |
20110249910 | IMAGE QUALITY ASSESSMENT INCLUDING COMPARISON OF OVERLAPPED MARGINS - Image quality is assessed for a digital image that is a composite of tiles or other image segments, especially focus accuracy for a microscopic pathology sample. An algorithm or combination of algorithms correlated to image quality is applied to pixel data at margins where adjacent image segments overlap and thus contain the same content in separately acquired images. The margins may be edges merged to join the image segments smoothly into a composite image, and typically occur on four sides of the image segments. The two versions of the same image content at each margin are processed by the quality algorithm, producing two assessment values. A sign and difference value are compared with other image segments, including by subsets selected for the orientation of the margins on sides on the image segments. The differences are mapped to displays. Selection criteria determine segments to be re-acquired. | 10-13-2011 |
20150050650 | METHODS FOR GENERATING AN IMAGE OF A BIOLOGICAL SAMPLE - A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods. | 02-19-2015 |
20150065371 | IMMUNOFLUORESCENCE AND FLUORESCENT-BASED NUCLEIC ACID ANALYSIS ON A SIMGLE SAMPLE - A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample, generating a second image of the biological sample, and generating a composite image that provides the relative location of both the target protein and the target nucleic acid. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are system and kit that comprise the means for executing the novel methods. | 03-05-2015 |
Patent application number | Description | Published |
20080266440 | PREDICTIVE AUTOFOCUSING - A method of autofocusing includes capturing first, second and third images of a sample, at respective first, second and third sample distances and respective first, second and third lateral positions determined with respect to an objective; determining a quantitative characteristic for the first, second and third images; determining a primary sample distance based upon at least the quantitative characteristics for the first, second, and third images; and capturing a primary image of the sample at the primary sample distance and at a primary lateral position that is offset from the first, second and third lateral positions. | 10-30-2008 |
20090195688 | System and Method for Enhanced Predictive Autofocusing - In an imaging device having an objective and a stage for holding a sample to be imaged, a method for autofocusing is presented. The method includes determining a measured focus value corresponding to at least a first of a plurality of logical image segments. Further, the method includes imaging the first logical image segment using the measured focus value. The method also includes determining a predicted focus value for a second of the plurality of logical image segments using the measured focus value and a stored focus variation parameter. In addition, the method includes imaging the second logical image segment using the predicted focus value. | 08-06-2009 |
20100301230 | METHOD AND APPARATUS FOR ULTRAVIOLET SCAN PLANNING - The invention provides method for locating one or more substantially circular-shaped tissue sample positioned on a solid support. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support. | 12-02-2010 |
20110090326 | SYSTEM AND METHOD FOR IMAGING WITH ENHANCED DEPTH OF FIELD - A method for imaging is presented. The method includes acquiring a plurality of images corresponding to at least one field of view using an imaging device having an objective and a stage for holding a sample to be imaged. Furthermore, the method includes determining a figure of merit corresponding to each pixel in each of the plurality of acquired images, wherein the figure of merit comprises a discrete approximation to a gradient vector. The method also includes synthesizing a composite image based upon the determined figures of merit. | 04-21-2011 |
20110090327 | SYSTEM AND METHOD FOR IMAGING WITH ENHANCED DEPTH OF FIELD - A method for imaging is presented. The method includes acquiring a plurality of images corresponding to overlapping fields of view at a plurality of sample distances using an imaging device having an objective and a stage for holding a sample to be imaged. Moreover, the method includes determining a figure of merit corresponding to each pixel in each of the plurality of acquired images. The method also includes synthesizing a composite image based upon the determined figures of merit. | 04-21-2011 |
20110091125 | SYSTEM AND METHOD FOR IMAGING WITH ENHANCED DEPTH OF FIELD - A method for imaging is presented. The method includes acquiring a plurality of images corresponding to at least one field of view at a plurality of sample distances. Furthermore, the method includes determining a figure of merit corresponding to each pixel in each of the plurality of acquired images. The method also includes for each pixel in each of the plurality of acquired images identifying an image in the plurality of images that yields a best figure of merit for that pixel. Moreover, the method includes generating an array for each image in the plurality of images. In addition, the method includes populating the arrays based upon the determined best figures of merit to generate a set of populated arrays. Also, the method includes processing each populated array in the set of populated arrays using a bit mask to generate bit masked filtered arrays. Additionally, the method includes selecting pixels from each image in the plurality of images based upon the bit masked filtered arrays. The method also includes processing the bit masked arrays using a bicubic filter to generate a filtered output. Further, the method includes blending the selected pixels as a weighted average of corresponding pixels across the plurality of images based upon the filtered output to generate the composite image having an enhanced depth of field. | 04-21-2011 |
20130044933 | SYSTEM AND METHODS FOR GENERATING A BRIGHTFIELD IMAGE USING FLUORESCENT IMAGES - A method for generating a brightfield type image, which resembles a brightfield staining protocol of a biological sample, using fluorescent images is provided. The steps comprise acquiring two or more fluorescent images of a fixed area on a biological sample, mapping said fluorescent image into a brightfield color space, generating a brightfield image, and optionally applying a sharpening transformation correction. Also provided is an image analysis system for generating a brightfield type image of a biological sample using fluorescent images. | 02-21-2013 |
20130178392 | METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE - Methods comprising the use probing multiple targets in a H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, observing the sample, removing the hematoxylin and partially removing the eosin by washing the sample, contacting the sample with a borate salt, and irradiating the sample to remove the residual eosin fluorescence. The method further includes the optionally performing the additional steps of binding at least one probe to one or more targets to the sample ,observing a signal from the probe and contacting the sample with a bleaching agent. The process of binding, observing and bleaching may be iteratively repeated. | 07-11-2013 |
20140267671 | REFERENCING IN MULTI-ACQUISITION SLIDE IMAGING - Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform. | 09-18-2014 |
20140270425 | IMAGE QUALITY ASSESSMENT OF MICROSCOPY IMAGES - Automated assessment of registration quality, focus, and area defects in sequentially acquired images, such as images acquired by a digital microscope, is disclosed. In one embodiment, acquired images are registered and whole-image defects are automatically detected based on a figure of merit generated by the registration process. In related implementations, area defects may be automatically detected by calculating correlations in localized image regions for images acquired in different imaging rounds. | 09-18-2014 |