Patent application number | Description | Published |
20090302952 | Systems And Methods For Distributing A Clock Signal - Systems and methods for distributing a clock signal are disclosed. In some embodiments, systems for distributing a clock signal include a plurality of resonant oscillators, each comprising an inductor; and a differential clock grid that distributes the clock signal. The differential clock grid is coupled to the plurality of resonant oscillators and the clock signal, and the inductances of the inductors are configured such that a resonant frequency of the plurality of resonant oscillators is substantially equal to the frequency of the clock signal. | 12-10-2009 |
20100300899 | Active CMOS Sensor Array For Electrochemical Biomolecular Detection - Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time. | 12-02-2010 |
20130180867 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOPORES - A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any. | 07-18-2013 |
20130224879 | SYSTEMS AND METHODS FOR A DNA-BASED THERMOMETER - DNA-based temperature sensor for measuring temperature through a transition of one or more strands of DNA from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the DNA is in the coupled configuration, includes a receptacle adapted to receive the DNA and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a DNA-based temperature sensing solution are also provided. | 08-29-2013 |
20140048416 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOPORES - A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any. | 02-20-2014 |
20140152278 | SYSTEMS AND METHODS FOR SWITCHED-INDUCTOR INTEGRATED VOLTAGE REGULATORS - Power controller includes an output terminal having an output voltage, at least one clock generator to generate a plurality of clock signals and a plurality of hardware phases. Each hardware phase is coupled to the at least one clock generator and the output terminal and includes a comparator. Each hardware phase is configured to receive a corresponding one of the plurality of clock signals and a reference voltage, combine the corresponding clock signal and the reference voltage to produce a reference input, generate a feedback voltage based on the output voltage, compare the reference input and the feedback voltage using the comparator and provide a comparator output to the output terminal, whereby the comparator output determines a duty cycle of the power controller. An integrated circuit including the power controller is also provided. | 06-05-2014 |
20140217264 | SYSTEMS AND METHODS FOR IMAGING USING SINGLE PHOTON AVALANCHE DIODES - Single-photon avalanche diode includes a central junction having a central p+ area and a deep-n well in contact with the central p+ area, a p-type guard ring disposed between the central junction and the deep-n well, and a shallow trench isolation separated from the central p+ area. Imaging apparatus includes a plurality of pixels, each pixel comprising a complementary metal-oxide-semiconductor-implemented single photon avalanche device and one or more signal converters electrically coupled thereto and configured to detect changes in output therefrom. | 08-07-2014 |
20150090588 | SYSTEMS AND METHODS FOR BIOLOGICAL ION CHANNEL INTERFACES - Method for interfacing an integrated circuit with a biological ion channel, the integrated circuit being at least partially disposed within an electrolytic solution and including an amplifier and one or more electrodes on a surface thereof, includes forming one or more microwells proximate the one or more electrodes, applying a lipid membrane over the integrated circuit proximate the microwells, and placing a further electrode in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit. A biological ion channel interface is also provided. | 04-02-2015 |
20150093849 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE NUCLEIC-ACID ASSAY PLATFORMS - Integrated circuits for a single-molecule nucleic-acid assay platform, and methods for making such circuits are disclosed. In one example, a method includes transferring one or more carbon nanotubes to a complementary metal-oxide semiconductor (CMOS) substrate, and forming a pair of post-processed electrodes on the substrate proximate opposing ends of the one or more carbon nanotubes. | 04-02-2015 |