Patent application number | Description | Published |
20130324417 | DETERMINING THE CLINICAL SIGNIFICANCE OF VARIANT SEQUENCES - The present invention generally relates to determining the clinical significance of a variant nucleic acid sequence. The invention can involve sequencing a nucleic acid to generate at least one sequence read, identifying a variant sequence within the sequence read, determining the equivalent insertion/deletion region (EIR) of the variant sequence, identifying a functional region including at least a portion of the EIR, and associating the EIR with the identified functional region, thereby to determine the clinical significance of the variant. | 12-05-2013 |
20140129201 | VALIDATION OF GENETIC TESTS - The invention provides a method for validating a genetic test by introducing a simulated mutation into sequence reads. By editing the information in one or more sequence read files, a set of sequence reads can be manipulated to represent an expected genotype. An analysis of those sequence reads produces an observed genotype and concordance between the expected and observed genotypes validates the analysis. Thus, the invention provides methods for validating new genetic tests. | 05-08-2014 |
20140255931 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 09-11-2014 |
20140361911 | METHODS AND SYSTEMS FOR STORING SEQUENCE READ DATA - The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters. | 12-11-2014 |
20160115534 | ANALYSIS METHODS - The invention generally relates to methods for analyzing nucleic acids to identify novel mutations associated with diseases. In certain embodiments, methods of the invention involve obtaining nucleic acid from a subject having a disease, identifying at least one mutation in the nucleic acid, and comparing the mutation to a database of mutations known to be associated with the disease, wherein mutations that do not match to the database are identified as novel mutations. | 04-28-2016 |
Patent application number | Description | Published |
20130268206 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 10-10-2013 |
20150149510 | METHODS AND SYSTEMS FOR STORING SEQUENCE READ DATA - The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters. | 05-28-2015 |
20160048608 | SYSTEMS AND METHODS FOR GENETIC ANALYSIS - The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation. | 02-18-2016 |
Patent application number | Description | Published |
20110184921 | System and Method for Data Driven De-Duplication - Described are computer-based methods and apparatuses, including computer program products, for removing redundant data from a storage system. In one example, a data delineation process delineates data targeted for de-duplication into regions using a plurality of markers. The de-duplication system determines which of these regions should be subject to further de-duplication processing by comparing metadata representing the regions to metadata representing regions of a reference data set. The de-duplication system identifies an area of data that incorporates the regions that should be subject to further de-duplication processing and de-duplicates this area with reference to a corresponding area within the reference data set. | 07-28-2011 |
20110184966 | System and Method for Summarizing Data - Described are computer-based methods and apparatuses, including computer program products, for removing redundant data from a storage system. In one example, a data delineation process delineates data targeted for de-duplication into regions using a plurality of markers. The de-duplication system determines which of these regions should be subject to further de-duplication processing by comparing metadata representing the regions to metadata representing regions of a reference data set. The de-duplication system identifies an area of data that incorporates the regions that should be subject to further de-duplication processing and de-duplicates this area with reference to a corresponding area within the reference data set. | 07-28-2011 |
20110184967 | System and method for navigating data - Described are computer-based methods and apparatuses, including computer program products, for removing redundant data from a storage system. In one example, a data delineation process delineates data targeted for de-duplication into regions using a plurality of markers. The de-duplication system determines which of these regions should be subject to further de-duplication processing by comparing metadata representing the regions to metadata representing regions of a reference data set. The de-duplication system identifies an area of data that incorporates the regions that should be subject to further de-duplication processing and de-duplicates this area with reference to a corresponding area within the reference data set. | 07-28-2011 |
20120191669 | Detection and Deduplication of Backup Sets Exhibiting Poor Locality - Described are computer-based methods and apparatuses, including computer program products, for detection and deduplication of backup sets exhibiting poor locality. A first set of summaries of a first data set are determined, each summary of the first set of summaries being indicative of a data pattern in the first data set. A second set of summaries of a second data set are determined, each summary of the second set of summaries being indicative of a data pattern in the second data set. A set of comparison metrics are calculated, each comparison metric being based on a first subset of summaries from the first set of summaries and a second subset of summaries from the second set of summaries. A locality metric is calculated based on the set of comparison metrics indicative of whether the first data set and second data set exhibit poor locality. | 07-26-2012 |
20120191670 | Dynamic Deduplication - Described are computer-based methods and apparatuses, including computer program products, for dynamic deduplication. Data is processed using an algorithm that deduplicates the data based on a first set of parameters. A first moving average of a first deduplication performance metric is calculated for the algorithm over a time period. A second moving average of a second deduplication performance metric is calculated for the algorithm over the time period. It is determined that the first moving average satisfies a first criterion, the second moving average satisfies a second criterion, or both. The algorithm is reconfigured based on a second set of parameters to deduplicate data. | 07-26-2012 |
20140279956 | SYSTEMS AND METHODS OF LOCATING REDUNDANT DATA USING PATTERNS OF MATCHING FINGERPRINTS - A system configured to compute match potential between first data and second data is provided. The system includes data storage storing the first data and the second data, and at least one processor coupled to the data storage. The at least one processor is configured to identify a first sequence of fingerprints characterizing a first plurality of sections of the first data, the first sequence being ordered according to an order of the first plurality of sections within the first data; identify a second sequence of fingerprints comprising fingerprints that match fingerprints within the first sequence, the second sequence of fingerprints characterizing a second plurality of sections of the second data, the second sequence being ordered according to an order of the second plurality of sections within the second data; quantify a similarity between the first sequence and the second sequence; and adjust the match potential based on the similarity. | 09-18-2014 |
20140365450 | SYSTEM AND METHOD FOR MULTI-SCALE NAVIGATION OF DATA - A system configured to generate a macro-fingerprint from at least one predefined set of summaries is provided. The system includes data storage storing a first predefined set of summaries associated with a first region of data, each member of the first predefined set of summaries characterizing data within the first region of data; and at least one processor coupled to the data storage and configured to: read the first predefined set of summaries; select at least one first member from the first predefined set of summaries based on a value of the at least one first member; and store the at least one first member within a first macro-fingerprint. The first region of data may have a first size indicative of to a quantity of data included in the first region of data. The macro fingerprints are created from previously created smaller (micro) fingerprints without having to reread the data. | 12-11-2014 |
20150106345 | MULTI-NODE HYBRID DEDUPLICATION - According to at least one embodiment, a data storage system is provided. The data storage system includes memory, at least one processor in data communication with the memory, and a deduplication director component executable by the at least one processor. The deduplication director component is configured to receive data for storage on the data storage system, analyze the data to determine whether the data is suitable for at least one of summary-based deduplication, content-based deduplication, and no deduplication, and store, in a common object store, at least one of the data and a reference to duplicate data stored in the common object store. | 04-16-2015 |
Patent application number | Description | Published |
20120171245 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 07-05-2012 |
20130281431 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 10-24-2013 |
20130345218 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 12-26-2013 |
20140005192 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | 01-02-2014 |
20140005197 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | 01-02-2014 |
20140045869 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 02-13-2014 |
20140094473 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 04-03-2014 |
20140142119 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 05-22-2014 |
20140296201 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 10-02-2014 |
20150111871 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-23-2015 |
20150191468 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 07-09-2015 |
Patent application number | Description | Published |
20120197028 | Crosslinked Polymers with the Crosslinker as Therapeutic For Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-02-2012 |
20130225857 | Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-29-2013 |
20130323312 | Microspheres Including Oxidized Cellulose - A process for forming microspheres is disclosed. The process includes: forming a first plurality microspheres comprising at least one bioactive agent and modified cellulose; contacting the first plurality of microspheres with a solution of a biodegradable polymer to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres comprising the first plurality of microspheres. | 12-05-2013 |
20130323315 | Microspheres Including Oxidized Cellulose - A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres. | 12-05-2013 |
20140005375 | Medical Devices Based On Oxidized Cellulose | 01-02-2014 |
20140005376 | Dissolution of Oxidized Cellulose and Particle Preparation by Solvent and Non-Solvent Precipitation | 01-02-2014 |
20140005377 | Dissolution of Oxidized Cellulose and Particle Preparation by Dispersion and Neutralization | 01-02-2014 |
20140005378 | Dissolution of Oxidized Cellulose and Particle Preparation by Cross-Linking With Multivalent Cations | 01-02-2014 |
Patent application number | Description | Published |
20120155107 | METHODS AND APPARATUS TO RECEIVE LIGHT FROM A LASER VIA AIR FOR A FIBER OPTIC DISPLAY - Methods and apparatus for a free space coupler to receive light from a laser via air. In one embodiment, a system comprises a laser source, a mirror optically aligned to the laser source, a first mount to control a position of the mirror, a free-space coupler to receive light from the mirror, a beam splitter to receive light exiting the coupler, a first detector to receive light reflected from the beam splitter, a second mount coupled to the first detector and to the coupler to control a position of the coupler from information from the first detector, and a second detector to receive light reflected by the coupler and the mirror, wherein the second detector is coupled to the first mount for positioning the mirror with respect to the coupler. | 06-21-2012 |
20120155800 | METHODS AND APPARATUS FOR A FIBER OPTIC DISPLAY SCREEN HAVING AN ADJUSTABLE SIZE - Methods and apparatus for a fiber optic display screen of adjustable size. In one embodiment, a screen comprises: a plurality of pixels formed by a terminal end of at least one optical fiber, wherein the pixels are substantially equidistant from each other along a first axis in a first screen size and in a second screen size that is larger than the first size. | 06-21-2012 |
20120155816 | METHODS AND APPARATUS FOR A MULTI-CONTENT FIBER OPTIC DISPLAY SCREEN - Methods and apparatus for a fiber optic display screen that comprises pixels forming the screen, wherein each of the pixels comprise terminal ends of multiple optical fibers, wherein a first pixel comprises: a first optical fiber terminal end having a first cleaving to generate an image for a first viewing angle, and a second optical fiber terminal end having a second cleaving different than the cleaving of the first optical fiber terminal end to generate an image for a second viewing angle for providing different content at the first and second viewing angles. | 06-21-2012 |
20120155817 | METHODS AND APPARATUS FOR A DECOUPLED FIBER OPTIC DISPLAY - Methods and apparatus for a fiber optic display system. In one embodiment, a fiber optic display screen comprises a laser source, relay optics to receive an output from the laser source, condenser optics coupled to the relay optics, a digital pixelator coupled to the condenser optics, a fiber optic transmission line coupled to the digital pixelator, and a fiber optic screen provided by terminal ends of fibers in the fiber optic transmission line. | 06-21-2012 |
Patent application number | Description | Published |
20080300981 | CAMPAIGN OPTIMIZATION - Methods, systems, and software for combinatorial optimization are described. A first combination of offers are selected from a list of combinations of offers that pass a first set of rules belonging to a first category of rules, and it is determined whether the first combination of offers passes a second set of rules belonging to a second, different category of rules. If the first combination passes the second set of rules, the first combination is returned as a solution. | 12-04-2008 |
20090177522 | CONTACT STREAM OPTIMIZATION - Methods, systems, and software for conducting a marketing campaign are described. One or more scores associated with sending offers to proposed contacts are received; and an overall campaign score corresponding to a sum of the scores is optimized to generate optimal assignments of offers to customers. The optimal assignments are included in the marketing campaign. | 07-09-2009 |
20110307328 | Response Attribution Valuation - A computer-implemented method is described for determining a response attribution value that represents a credit assignment to a communication, for an associated response received from a recipient during a marketing campaign. | 12-15-2011 |
20120116787 | Response Attribution Valuation - A computer-implemented method is described for determining a response attribution value that represents a credit assignment to a communication, for an associated response received from a recipient during a marketing campaign. | 05-10-2012 |
20120185326 | CONTACT STREAM OPTIMIZATION USING FEC AND CC CONSTRAINTS - Methods, systems, and software for conducting a marketing campaign are described. One or more scores associated with sending offers to proposed contacts are received; and an overall campaign score corresponding to a sum of the scores is optimized to generate optimal assignments of offers to customers. The optimal assignments are included in the marketing campaign. | 07-19-2012 |
20120290371 | RESPONSE ATTRIBUTION VALUATION - A computer-implemented method is described for determining a response attribution value that represents a credit assignment to a communication, for an associated response received from a recipient during a marketing campaign. | 11-15-2012 |
20120290385 | RESPONSE ATTRIBUTION VALUATION - A computer-implemented method is described for determining a response attribution value that represents a credit assignment to a communication, for an associated response received from a recipient during a marketing campaign. | 11-15-2012 |
20150381989 | Iterative Video Optimization for Data Transfer and Viewing - Computer-implemented techniques that leverage available CPU resources to incrementally improve quality and compression of media for faster transfer over data networks for improved viewing are described. | 12-31-2015 |
Patent application number | Description | Published |
20110113026 | Scalable Computation of Data - Techniques for producing a cross tabulation are described. The techniques involve issuing a plurality of queries to a database. The queries are for each of at least one sublevel of data for each of at least one dimension of data associated with records in the database. The queries provide sublists of sorted identifiers for each one of the queries. The technique determines occurrences of intersections of levels of one dimension with levels of another dimension of the data associated with records in the database by traversing the sublists to detect intersections of the dimensions. | 05-12-2011 |
20130346184 | CONTACT HISTORY FOR PROMOTION MANAGEMENT - A computer implemented method for producing a contact history for a marketing campaign is described. The method includes producing a promotion version history table for the marketing campaign, with the promotion version history table recording promotion attribute values for each promotion version at runtime, producing a treatment history table for the marketing campaign, with the treatment history table representing promotion instances given to a group, producing a contact history table for the marketing campaign, the contact history table recording which contact entities were in which groups at runtime, linking the promotion version history table, the treatment history table, and the contact history table, wherein the linking preserves referential integrity between the promotion version history table, the treatment history table, and the contact history table, and producing the contact history from the promotion version history table, the treatment history table, and the contact history table. | 12-26-2013 |
20130346185 | TRACKING RESPONSES TO PROMOTIONS - A computer implemented method for response tracking is described. The method includes obtaining one or more responses to one or more promotions, attributing the one or more responses to one or more treatment instances, with the one or more treatment instances correspond to a promotion version assigned to a group of contact entities at an execution of a computer implemented marketing campaign, and generating a response table, the response table including one or more entries, the entries in the response table being in accordance with attribution of the one or more responses to one or more treatment instances. | 12-26-2013 |
20130346216 | TECHNIQUES FOR ASSIGNING PROMOTIONS TO CONTACT ENTITIES - A computer implemented method for target group management is described. The method includes producing a table including one or more group entries corresponding to one or more defined contact group entities with each of the entries having a first set of group attributes, and producing a visual representation of a marketing campaign, the representation including one or more instances of defined contact group entities, with the one or more instances having a second set of group attributes and with the representation linked to the table according to the second set of group attributes. | 12-26-2013 |
20160092913 | TIME INTERVAL-BASED STATISTICALLY-INFERRED RESPONSE ATTRIBUTIONS - A time interval-based stimulus is created based upon a statistically-inferred time interval-based response rate. The time interval-based stimulus accounts over time for a proportion of responses that occur without being attributable to other stimuli. A response is retrieved. A time-interval response attribution value is calculated using the time interval-based stimulus and the response by applying a combination of a first response rate model and a second time delay model that weights output of the first response rate model based upon a continuous range of time delays between a minimum and maximum difference in time that separate the time interval-based stimulus and the response. | 03-31-2016 |
20160092925 | TIME INTERVAL-BASED STATISTICALLY-INFERRED RESPONSE ATTRIBUTIONS - A time interval-based stimulus is created based upon a statistically-inferred time interval-based response rate. The time interval-based stimulus accounts over time for a proportion of responses that occur without being attributable to other stimuli. A response is retrieved. A time-interval response attribution value is calculated using the time interval-based stimulus and the response by applying a combination of a first response rate model and a second time delay model that weights output of the first response rate model based upon a continuous range of time delays between a minimum and maximum difference in time that separate the time interval-based stimulus and the response. | 03-31-2016 |
Patent application number | Description | Published |
20080274827 | GOLF BALL - A golf ball component, such as a golf ball cover layer, formed from a high or increased melt index thermoplastic polyurethane, polyurea or polyurethane/polyurea is disclosed. The cover layer may be relatively thin (i.e., 0.075 or less, preferably 0.050 inches or less, more preferably less than 0.040 inches, even more preferably less than 0.030 inches). In addition, an operation in which the outer cover is exposed to an isocyanate solution is described to improve certain physical properties of the resulting golf ball. | 11-06-2008 |
20120021850 | Golf Ball And Method Of Manufacturing A Golf Ball - A golf ball and a method of manufacturing a golf ball is disclosed. In one embodiment, a method of manufacturing a golf ball includes molding a cover made of thermoplastic resin over at least one intermediate layer of a golf ball; permeating an isocyanate solution comprising an isocyanate compound and a co-reactant compound into an outer portion of the cover; and permeating a catalyst into the outer portion of the cover. The catalyst catalyzes a reaction between the isocyanate compound and the co-reactant compound to form a reaction product. The co-reactant compound can be a second isocyanate compound, the catalyst can be a quaternary ammonium salt, and the reaction product can be isocyanurate. The reaction product modifies at least one physical property of the outer portion such that the physical property of the outer portion is different than the physical property of the inner portion. The modified physical property can be microindentation hardness, where the microindentation hardness of the outer portion is greater than the microindentation hardness of an inner portion of the cover. | 01-26-2012 |