Patent application number | Description | Published |
20090124714 | POROUS RESIN PARTICLE HAVING HYDROXY GROUP OR PRIMARY AMINO GROUP AND PRODUCTION METHOD THEREOF - The present invention relates to a method for producing a porous resin particle having a functional group X, the method including: dissolving a radical polymerizable aromatic monovinyl monomer and a radical polymerizable aromatic divinyl monomer together with a polymerization initiator in an organic solvent to prepare a monomer solution, dispersing the monomer solution in water in the presence of a dispersion stabilizer to obtain a suspension polymerization reaction mixture, and performing a suspension copolymerization while adding, when 0 to 80% of the entire polymerization time of the suspension copolymerization is passed, a mercapto compound represented by the formula (I): | 05-14-2009 |
20090137692 | PRODUCTION METHOD OF POROUS RESIN PARTICLE HAVING HYDROXYL GROUP - The present invention relates to a method for producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an aromatic divinyl compound and a (meth)acrylic acid ester having one hydroxyl group within the molecule thereof, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; and performing a suspension copolymerization. The method of the invention is capable of easily producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, that is used as a support for solid phase synthesis and enables efficient nucleic acid synthesis. | 05-28-2009 |
20090291294 | SOLID-PHASE SUPPORT FOR NUCLEIC ACID SYNTHESIS - According to the invention, there is provided a solid-phase support for nucleic acid synthesis, which is constituted of a porous copolymer particle containing a multifunctional vinyl monomer unit having two or more vinyl groups in one molecule and a monofunctional vinyl monomer unit having one vinyl group in one molecule, in which the solid-phase support has a swelling volume when soaked in acetonitrile of 3.5 ml/g or more and has a median particle diameter measured by a laser scattering particle size distribution measuring method within a range of from 50 to 120 ρm. According to the solid-phase support for nucleic acid synthesis of the invention, a high-purity nucleic acid can be synthesized with a high yield. | 11-26-2009 |
20090292033 | PROCESS FOR PRODUCING POROUS POLYMER PARTICLES - According to the invention, there is provided a process for producing porous polymer particles, which includes: dissolving in an organic solvent a monomer mixture containing an aromatic vinyl monomer and an aromatic divinyl monomer as major components together with a polymerization initiator to obtain a monomer solution; dispersing the monomer solution in water containing a dispersant and sodium nitrite to obtain a suspension polymerization dispersion; suspension-polymerizing the monomers in the suspension polymerization dispersion to yield porous polymer particles; and separating the porous polymer particles by filtration through a filter medium, in which the sodium nitrite is incorporated into the water in an amount in the range of 0.005 to 0.1 mg per 1 g of the water. | 11-26-2009 |
20110065818 | POROUS RESIN BEAD AND METHOD FOR PRODUCING NUCLEIC ACID USING THE SAME - The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a dry volume of from 2 to 3 ml/g. | 03-17-2011 |
20110065822 | POROUS RESIN BEAD AND METHOD FOR PRODUCING NUCLEIC ACID USING THE SAME - The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a swelling volume in acetonitrile of from 3 to 6 ml/g. | 03-17-2011 |
20110092690 | LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID - The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae | 04-21-2011 |
20130197117 | LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID - The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula | 08-01-2013 |