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Kawaminami
Eiji Kawaminami, Chuo-Ku JP
| Patent application number | Description | Published |
|---|---|---|
| 20100173946 | BENZIMIDAZOLYLIDENE PROPANE-1,3-DIONE DERIVATIVE OR SALT THEREOF - Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like. In addition, since the compound of the invention is excellent in metabolic stability in human and also is less in drug interaction, it has more desirable properties as a medicament to be used for the aforementioned diseases. | 07-08-2010 |
Eiji Kawaminami, Tokyo JP
| Patent application number | Description | Published |
|---|---|---|
| 20090018177 | Propane-1,3-Dione Derivative or Salt Thereof - Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like. In addition, since the compound of the invention is excellent in metabolic stability in human and also is less in drug interaction, it has more desirable properties as a medicament to be used for the aforementioned diseases. | 01-15-2009 |
| 20090181964 | Propane-1,3-Dione Derivative or Salt Thereof - It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by —SO | 07-16-2009 |
Hiroshi Kawaminami, Tsuruga-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20080220460 | MODIFIED FLAVIN ADENINE DINUCLEOTIDE DEPENDENT GLUCOSE DEHYDROGENASE - Object: An object of the present invention is to provide a more practically advantageous enzyme usable as a reagent for measuring blood glucose than the known enzymes used as blood glucose sensors. | 09-11-2008 |
| 20090155848 | NOVEL GLUCOSE DEHYDROGENASE - The present invention provides glucose dehydrogenase which is excellent in heat resistance and substrate specificity and is not affected by dissolved oxygen. Specifically, the present invention relates to glucose dehydrogenase characterized by being derived from an eukaryotic organism and keeping 90% or more activity after being treated with heat at 55° C. for 15 minutes in a liquid form compared with the activity before being treated. | 06-18-2009 |
| 20090317848 | MODIFIED FLAVIN ADENINE DINUCLEOTIDE DEPENDENT GLUCOSE DEHYDROGENASE - The invention provides a modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH), as well as a glucose sensor comprising the modified FADGDH and a method for measuring glucose comprising using the glucose sensor to measure glucose of a sample | 12-24-2009 |
Mitsuhiro Kawaminami, Okazaki-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20110132706 | VIBRATION DAMPING DEVICE - A vibration damping device for a vibration damping target has a linear member that includes a plurality of wires, which are held so that each of the plurality of wires is relatively displaced in a state that the wires are in contact with one another, and a cover member that covers a peripheries of the plurality of the wires, wherein the plurality of the wires and part of the cover member are fixed to the vibration damping target, and a region of the linear member that flexes through plastic deformation of the linear member is located near each point where the linear member is fixed to the vibration damping target. | 06-09-2011 |
Shuichi Kawaminami, Kanagawa JP
| Patent application number | Description | Published |
|---|---|---|
| 20090317682 | Oxide single crystal and method for production thereof, and single crystal wafer - An oxide single crystal having a composition represented by RE | 12-24-2009 |