Patent application number | Description | Published |
20080227655 | Assessment of effect of an agent on a human biological condition using rodent gene expression panels - Rodent gene expression data, in particular, gene expression profiles, are created and used to predict the efficacy of therapeutic agents on human biological conditions. Gene Profile data sets are derived from rodent subject samples and include quantitative, substantially repeatable measures of a distinct amount of RNA or protein constituent(s) in a signature panel selected such that measurement of the constituent(s) enables measurement of a biological condition of interest in both human and rodent subjects. Such profile data sets may be used to predict the therapeutic efficacy of a therapeutic agent in humans. | 09-18-2008 |
20080233573 | Gene expression profiling for identification, monitoring and treatment of transplant rejection - The present invention provides methods of characterizing organ transplant rejection or inflammatory conditions associated with organ transplant rejection using gene expression profiling. | 09-25-2008 |
20100184034 | Gene Expression Profiling for Identification, Monitoring and Treatment of Lung Cancer - A method is provided in various embodiments for determining a profile data set for a subject with lung cancer or conditions related to lung cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that arc substantially repeatable. | 07-22-2010 |
20100196889 | Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer - A method is provided in various embodiments for determining a profile data set for a subject with colorectal cancer or conditions related to colorectal cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 08-05-2010 |
20100209915 | Gene Expression Profiling for Identification, Monitoring, and Treatment of Ocular Disease - A method is provided in various embodiments for determining a profile data set for a subject with ocular disease or conditions related to ocular disease based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least one constituent from Tables 1-5, 7-9, and 11-13. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 08-19-2010 |
20100216137 | Gene Expression Profiling for Identification, Monitoring and Treatment of Ovarian Cancer - A method is provided in various embodiments for determining a profile data set for a subject with ovarian cancer or conditions related to ovarian cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 08-26-2010 |
20100233691 | Gene Expression Profiling for Identification, Monitoring and Treatment of Prostate Cancer - A method is provided in various embodiments for determining a profile data set for a subject with prostate cancer or conditions related to prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-4. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 09-16-2010 |
20100248225 | GENE EXPRESSION PROFILING FOR IDENTIFICATION, MONITORING AND TREATMENT OF MELANOMA - A method is provided in various embodiments for determining a profile data set for a subject with skin cancer or a condition related to skin cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-6. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 09-30-2010 |
20100255470 | Gene Expression Profiling for Identification, Monitoring and Treatment of Breast Cancer - A method is provided in various embodiments for determining a profile data set for a subject with breast cancer or conditions related to breast cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 10-07-2010 |
20100330558 | Gene Expression Profiling for Identification, Monitoring and Treatment of Cervical Cancer - A method is provided in various embodiments for determining a profile data set for a subject with cervical cancer or conditions related to cervical cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 12-30-2010 |
20110070582 | Gene Expression Profiling for Predicting the Response to Immunotherapy and/or the Survivability of Melanoma Subjects - A method is provided in various embodiments for determining a profile data set for predicting the response top immunotherapy and or survivability of a subject with melanoma based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions that are substantially repeatable for measuring the amount of RNA corresponding to at least 2, 3 or 4 constituents according to the gene models shown in Tables 2-3, 4-6 and 9. | 03-24-2011 |
20110092390 | ASSESSMENT OF EFFECT OF AN AGENT ON A HUMAN BIOLOGICAL CONDITION USING RODENT GENE EXPRESSION PANELS - Rodent gene expression data, in particular, gene expression profiles, are created and used to predict the efficacy of therapeutic agents on human biological conditions. Gene Profile data sets are derived from rodent subject samples and include quantitative, substantially repeatable measures of a distinct amount of RNA or protein constituent(s) in a signature panel selected such that measurement of the constituent(s) enables measurement of a biological condition of interest in both human and rodent subjects. Such profile data sets may be used to predict the therapeutic efficacy of a therapeutic agent in humans. | 04-21-2011 |
20110306512 | Gene Expression Profiling for Identification, Monitoring, and Treatment of Osteoarthritis - A method is provided in various embodiments for determining a profile data set for a subject with osteoarthritis or conditions related to osteoarthritis based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least one constituent from Tables 1-2, 4-6, and 8. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 12-15-2011 |
20120009581 | Gene Expression Profiling for Predicting the Survivability of Prostate Cancer Subjects - A method is provided in various embodiments for determining a profile data set for predicting the survivability of a subject with prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions that are substantially repeatable for measuring the amount of RNA corresponding to at least 1 constituent from Table 1. Alternatively, the method uses electrophoresis or immunohistochemistry for measuring the mount of protein corresponding to at least 1 constituent from Table 20. The profile data set comprises the measure of each constituent. | 01-12-2012 |
20120301887 | Gene Expression Profiling for the Identification, Monitoring, and Treatment of Prostate Cancer - A method is provided in various embodiments for determining a profile data set for a subject with prostate cancer or a condition related to prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Table 1 and/or Table 8 in conjunction with PSA. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 11-29-2012 |
20140024547 | Gene Expression Profiling For Identification, Monitoring And Treatment Of Colorectal Cancer - A method is provided in various embodiments for determining a profile data set for a subject with colorectal cancer or conditions related to colorectal cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-5. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 01-23-2014 |