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Karow, US
Margaret Karow, Camarillo, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090156492 | Methods of Using IL-1 Antagonists to Treat Autoinflammatory Disease - Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is an IL-1 trap, preferably comprising a sequence selected from the group consisting of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or a substantially identical having at least 95% identity to the sequence shown in SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26 and capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), or systemic onset juvenile rheumatoid arthritis (Still's Disease). | 06-18-2009 |
| 20100034833 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-18 RECEPTOR - An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof. | 02-11-2010 |
| 20100316627 | Human antibodies to human IL-6 receptor - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 12-16-2010 |
| 20100316636 | Method of Treating Rheumatoid Arthritis with an IL-6R Antibody - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 12-16-2010 |
| 20110269187 | High Affinity Human Antibodies to Human IL-18 Receptor - An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof. | 11-03-2011 |
Margaret Karow, Putnam Valley, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080300181 | Methods of using IL-1 antagonists to treat neointimal hyperplasia - Methods of using interleukin-1 (IL-1) antagonists to prevent or treat restenosis and other neointimal hyperplasia conditions, including atherosclerosis, vascular access dysfunction, hypertension and related vascular diseases are provided. | 12-04-2008 |
Margaret Karow, Sant Rosa Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110311537 | METHODS OF USING IL-1 ANTAGONISTS TO TREAT FAMILIAL MEDITERRANEAN FEVER (FMF) - Methods of treating, inhibiting, or ameliorating Familial Mediterranean Fever (FMF) by administering to a subject in need thereof a therapeutically effective amount of an interleukin 1 (IL-1) antagonist, are provided. The IL-1 antagonist can be an antibody or derivative thereof, which is capable of blocking or inhibiting the biological action of IL-1, thereby treating, inhibiting or ameliorating FMF. Also provided are methods of treating, inhibiting, or ameliorating FMF by administering a therapeutically effective amount of an IL-1 antagonist in combination with additional therapeutic agents, including IL-1-specific fusion proteins, TNF inhibitors, NSAIDs, steroids, and the like. | 12-22-2011 |
Margaret Karow, Santa Rosa Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110318342 | METHODS OF USING IL-1 ANTAGONISTS TO TREAT AUTOINFLAMMATORY DISEASE - Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still's Disease). | 12-29-2011 |
Mark Karow, Burlington, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100162942 | Collapsible Construction Barrier - A collapsible barrier has at least three integrally-formed wall sections with a plurality of contiguous living hinges, as a series, joining each adjacent pair of wall sections, the at least three wall sections including two endmost wall sections joinable to form an upright structure. A collapsible barrier may include a plurality of interconnected wall sections each having a top-facing side, where one of the top-facing sides has a pocket adapted for securely holding a light. A thermoformed unitary plastic object may include at least two wall sections, at least one hinge member connecting adjacent interior ones of the wall sections' longitudinal sides, the hinge member comprising a plurality of interconnected living hinges, where a nominal thickness of the at least one hinge members of the thermoformed unitary plastic object approximates 0.100 inch. | 07-01-2010 |
Meredith Karow, Hatboro, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100084300 | CARD STRUCTURES FOR ENHANCED STACKING STRENGTH - A display card ( | 04-08-2010 |
Merideth Karow, Hatboro, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100193392 | BLISTER CARD PACKAGING STRUCTURE WITH A VIEWING PANEL - A package structure includes a viewing panel ( | 08-05-2010 |
Philip Karow, Twin Lakes, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100166513 | Simultaneous Pipe Cutting and Chamfering Device - A mobile device for simultaneously cutting and chamfering a pipe is provided having a frame, at least one pipe collet-clamp attached to the frame and defining a principal axis, a split carriage rotatably mounted with respect to the frame about the axis and adjacent to the clamp(s), a router affixed to the split carriage and having a cutting-chamfering bit, and a drive motor for rotating the carriage. The router orbits around the pipe and simultaneously cuts it into two chamfered pipes. A method is also provided for cutting through a pipe and chamfering the cut ends thereof. | 07-01-2010 |
| 20100166516 | Cutting and Chamfering Router Bit for Pipe - A bit for simultaneously cutting and chamfering a pipe is provided having a shaft defining an axis and having a shank portion at its proximal end and a working portion at its distal end. The working portion has a distal-most depth-cutting portion with at least one axially-offset leading cutting edge at the circumference of the shaft, a substantially axially-parallel lateral cutting edge extending from the distal end along the length of the depth-cutting portion and at least one chamfer-cutting portion between the depth-cutting portion and the shank portion. | 07-01-2010 |