Karl G.
Karl G. Csaky, Kensington, MD US
Patent application number | Description | Published |
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20100272777 | OCULAR THERAPEUTIC AGENT DELIVERY DEVICES AND METHDOS FOR MAKING AND USING SUCH DEVICES - Ocular implant devices ( | 10-28-2010 |
Karl G. Horschel, Springville, NY US
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20090078077 | Centering viscous torsional vibration damper - A viscous torsional vibration damper comprising a housing adapted to be connected to a rotary member to be damped, the housing comprising an annular chamber having an inner cylindrical surface and an outer cylindrical surface elongated about a central axis, an inertial mass within the chamber and having an inner cylindrical surface and an outer cylindrical surface elongated about an axis of rotation, the inertial mass and the chamber configured such that the inertial mass is rotatable in the chamber relative to the housing, a first annular centering element and a second annular centering element between the opposed inner cylindrical surfaces of the chamber and the inertial mass or the opposed outer cylindrical surfaces of the chamber and the inertial mass, the annular centering elements configured and arranged to bias the axis of rotation of the inertial mass towards alignment with the central axis of the chamber, a clearance gap between the housing and the inertial mass, the clearance gap having a first portion and a second portion separated by at least one of the centering elements, a bypass channel extending through the inertial mass or at least one of the centering elements from the first portion of the clearance gap to the second portion of the clearance gap, and a viscous fluid within the clearance gap. | 03-26-2009 |
Karl G. Proba, Zurich CH
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20100098722 | Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 04-22-2010 |
20110097417 | MELAN-A-CARRIER CONJUGATES - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 04-28-2011 |
Karl G. RosÉn, Kungälv SE
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20140245886 | METHOD AND ARRANGEMENTS FOR IMPROVING ANIMAL'S PERFORMANCE BY REDUCING THE AMOUNT OF BIOLOGICALLY ACTIVE PARTICLES IN THE STABLE AIR - A method and arrangement to improve animal's biological and/or physical performance by reducing the bioload, defined as biologically active particles in the stable air or within transporter vehicles. The method includes generating a negatively charged electrostatic field operating within the room capturing the particles. The arrangement includes elements for producing a negatively charged electrostatic field capturing air borne particulate matter whereby high voltage >6 kV at low amperage (<10 mA) is applied to a basic conductive structure positioned in the air of the stable or the transporter vehicle, to which carbon fibre filaments are attached, causing the release of electrons from the free ending carbon fibres into the air and thereby generating the negatively charged electrostatic field. | 09-04-2014 |
Karl G. Schwappach, North Oaks, MN US
Patent application number | Description | Published |
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20100279586 | ARRAY OF ABRASIVE MEMBERS WITH RESILIENT SUPPORT - An abrasive article having an array of abrasive members with an elastomeric support that permits each abrasive member to move independently in at least pitch and roll. Each abrasive member maintains a fluid bearing (air is the typical fluid) with the substrate. The abrasive members are capable of selectively engaging with nanometer-scale and/or micrometer-scale height variations and micrometer-scale and/or millimeter-scale wavelengths of waviness, on the surfaces of substrates. The spacing and pitch of the abrasive members can be adjusted to follow the topography of the substrate to remove a generally uniform layer of material; to engage with the peaks on the substrate to remove target wavelengths of waviness; and/or to remove debris and contamination from the surface of the substrate. | 11-04-2010 |
20110080675 | LOW HYSTERESIS BEARING - A low hysteresis pivot bearing suitable for a variety of applications. The relationship between torque and angular displacement is substantially linear, with negligible residual hysteresis. The pivot bearing includes a stationary shaft and at least one intermediate member pivotally connected to the stationary shaft by an intermediate member bearing. At least one outer sleeve is pivotally connected to the intermediate member by an outer sleeve bearing. At least one rotary actuator angularly displaces the intermediate member relative to the stationary shaft. | 04-07-2011 |
20110104989 | DRESSING BAR FOR EMBEDDING ABRASIVE PARTICLES INTO SUBSTRATES - One or more individually gimballed dressing bars for embedding abrasive particles into a substrate at a substantially uniform height. A hydrostatic and/or hydrodynamic fluid bearing (air is the typical fluid) is maintained between the dressing bar and the substrate. The fluid bearing permits the dressing bar to follow micrometer-scale and/or millimeter-scale wavelengths of waviness on the substrate, while maintaining a constant clearance, to uniformly embed the abrasive particle into the substrate. | 05-05-2011 |
20110159784 | ABRASIVE ARTICLE WITH ARRAY OF GIMBALLED ABRASIVE MEMBERS AND METHOD OF USE - An abrasive article with an array of independently gimballed abrasive members that are capable of selectively engaging with nanometer-scale and/or micrometer-scale height variations and micrometer-scale and/or millimeter-scale wavelengths of waviness, on the surfaces of substrates. Each abrasive member maintains a fluid bearing (air is the typical fluid) with the substrate. The spacing and pitch of the abrasive members can be adjusted to follow the topography of the substrate to remove a generally uniform layer of material; to engage with the peaks on the substrate to remove target wavelengths of waviness; and/or to remove debris and contamination from the surface of the substrate. | 06-30-2011 |
20120122380 | ABRASIVE ARTICLE WITH ARRAY OF COMPOSITE POLISHING PADS - A polishing article with a plurality of polishing pads adapted to polish a substrate. Gimbal structures are attached to the polishing pads that permit the polishing pads to move independently along at least a pitch axis and a roll axis. Stems supported by preload flexures apply preloads through dimple structures to the polishing pads. A plurality of stand-offs provide fixed boundary conditions between the preload and the gimbal structures. Recesses allow for the preload flexures to move vertically. | 05-17-2012 |
20120149279 | ABRASIVE ARTICLE WITH ARRAY OF COMPOSITE POLISHING PADS - An abrasive article for polishing a substrate surface. The abrasive article includes a holder pad assembly and an abrasive member held in place with respect to a holder pad. The abrasive member further includes a first surface engaged with the holder pad assembly, and a second surface including an abrasive. A preload mechanism is positioned to bias the second surfaces of the abrasive member toward the substrate surface. One or more fluid bearing features on the second surface of the abrasive member is configured to generate lift forces during relative motion between the abrasive article and the substrate surface. | 06-14-2012 |
20120149283 | ABRASIVE SLURRY AND DRESSING BAR FOR EMBEDDING ABRASIVE PARTICLES INTO SUBSTRATES - An abrasive polishing slurry including abrasive particles in a carrier fluid and micro-nano members. A system and method for making an abrasive article using the polishing slurry is also disclosed. The system includes a gimballed dressing bar adapted to provide a compressive force sufficient to embed the abrasive particles into the substrate, wherein the members set a height the embedded abrasive particles protrude above the substrate. | 06-14-2012 |
20130046351 | FIXATION SYSTEM FOR ORTHOPEDIC DEVICES - A fixation system configured to releasably secure an orthopedic implant to a bone. The fixation system including at least one expandable member that is inserted through the lumen and positioned in cancellous bone near the distal portion of the orthopedic implant. A delivery tube delivers a flowable biomaterial to the expandable member. The expand fixation structure includes at least one dimension greater than a corresponding dimension on the orthopedic implant to secure the orthopedic implant in the bone. An insert is secured in the lumen to releasably attach the fixation system to the orthopedic implant. The expandable member is detachable from the orthopedic implant to facilitate subsequent removal of the orthopedic implant from the bone. | 02-21-2013 |
Karl G. Sponsler, Canton, MI US
Patent application number | Description | Published |
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20110181088 | ROTARY RECLINER MECHANISM - A recliner mechanism ( | 07-28-2011 |
20120001049 | LATCH MECHANISM | 01-05-2012 |
20140191552 | SEATING SYSTEM FOR A RECUMBENT STEPPER - An adjustable seating apparatus for a recumbent stepper includes a seat base mounted to a carriage, which is mounted for longitudinal translation along a guide track. The seat base can be rotatable relative to the carriage. The seat base includes a first handle for releasing the carriage from an elongate positioning member to adjust the longitudinal position, and a second handle for releasing the seat base from a positioning plate to adjust the rotary position of the seat base relative to the carriage. When the seat base has been rotated from its nominal position, the carriage will generally be prevented from being released from the elongate positioning member. | 07-10-2014 |