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Karl G.
Karl G. Csaky, Kensington, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100272777 | OCULAR THERAPEUTIC AGENT DELIVERY DEVICES AND METHDOS FOR MAKING AND USING SUCH DEVICES - Ocular implant devices ( | 10-28-2010 |
Karl G. Horschel, Springville, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090078077 | Centering viscous torsional vibration damper - A viscous torsional vibration damper comprising a housing adapted to be connected to a rotary member to be damped, the housing comprising an annular chamber having an inner cylindrical surface and an outer cylindrical surface elongated about a central axis, an inertial mass within the chamber and having an inner cylindrical surface and an outer cylindrical surface elongated about an axis of rotation, the inertial mass and the chamber configured such that the inertial mass is rotatable in the chamber relative to the housing, a first annular centering element and a second annular centering element between the opposed inner cylindrical surfaces of the chamber and the inertial mass or the opposed outer cylindrical surfaces of the chamber and the inertial mass, the annular centering elements configured and arranged to bias the axis of rotation of the inertial mass towards alignment with the central axis of the chamber, a clearance gap between the housing and the inertial mass, the clearance gap having a first portion and a second portion separated by at least one of the centering elements, a bypass channel extending through the inertial mass or at least one of the centering elements from the first portion of the clearance gap to the second portion of the clearance gap, and a viscous fluid within the clearance gap. | 03-26-2009 |
Karl G. Proba, Zurich CH
| Patent application number | Description | Published |
|---|---|---|
| 20100098722 | Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 04-22-2010 |
| 20110097417 | MELAN-A-CARRIER CONJUGATES - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 04-28-2011 |
Karl G. Schwappach, North Oaks, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100279586 | ARRAY OF ABRASIVE MEMBERS WITH RESILIENT SUPPORT - An abrasive article having an array of abrasive members with an elastomeric support that permits each abrasive member to move independently in at least pitch and roll. Each abrasive member maintains a fluid bearing (air is the typical fluid) with the substrate. The abrasive members are capable of selectively engaging with nanometer-scale and/or micrometer-scale height variations and micrometer-scale and/or millimeter-scale wavelengths of waviness, on the surfaces of substrates. The spacing and pitch of the abrasive members can be adjusted to follow the topography of the substrate to remove a generally uniform layer of material; to engage with the peaks on the substrate to remove target wavelengths of waviness; and/or to remove debris and contamination from the surface of the substrate. | 11-04-2010 |
| 20110080675 | LOW HYSTERESIS BEARING - A low hysteresis pivot bearing suitable for a variety of applications. The relationship between torque and angular displacement is substantially linear, with negligible residual hysteresis. The pivot bearing includes a stationary shaft and at least one intermediate member pivotally connected to the stationary shaft by an intermediate member bearing. At least one outer sleeve is pivotally connected to the intermediate member by an outer sleeve bearing. At least one rotary actuator angularly displaces the intermediate member relative to the stationary shaft. | 04-07-2011 |
| 20110104989 | DRESSING BAR FOR EMBEDDING ABRASIVE PARTICLES INTO SUBSTRATES - One or more individually gimballed dressing bars for embedding abrasive particles into a substrate at a substantially uniform height. A hydrostatic and/or hydrodynamic fluid bearing (air is the typical fluid) is maintained between the dressing bar and the substrate. The fluid bearing permits the dressing bar to follow micrometer-scale and/or millimeter-scale wavelengths of waviness on the substrate, while maintaining a constant clearance, to uniformly embed the abrasive particle into the substrate. | 05-05-2011 |
| 20110159784 | ABRASIVE ARTICLE WITH ARRAY OF GIMBALLED ABRASIVE MEMBERS AND METHOD OF USE - An abrasive article with an array of independently gimballed abrasive members that are capable of selectively engaging with nanometer-scale and/or micrometer-scale height variations and micrometer-scale and/or millimeter-scale wavelengths of waviness, on the surfaces of substrates. Each abrasive member maintains a fluid bearing (air is the typical fluid) with the substrate. The spacing and pitch of the abrasive members can be adjusted to follow the topography of the substrate to remove a generally uniform layer of material; to engage with the peaks on the substrate to remove target wavelengths of waviness; and/or to remove debris and contamination from the surface of the substrate. | 06-30-2011 |
Karl G. Sponsler, Canton, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110181088 | ROTARY RECLINER MECHANISM - A recliner mechanism ( | 07-28-2011 |