Kari, US
Csaba Kari, Rosemont, PA US
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20110178279 | DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS: APPLICATION TO ANTI-EGFR ANTIBODIES - In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof. | 07-21-2011 |
20130150558 | DESIGN AND DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS; APPLICATION TO ANTI-EGFR ANTIBODIES - In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof. | 06-13-2013 |
David Fred Kari, Bloomingdale, IL US
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20110308993 | COLLAPSIBLE BULK BIN CONTAINER - A collapsible shipping container is capable of configured from a collapsed position for storage and transportation to a constructed position for containment of articles therein and back again to the collapsed position after use. The collapsible shipping container comprises a foldable tray having at least two pallet runner sleeves spaced apart from one another and each of which being formed on respective opposed lateral edges of the foldable tray. A plurality of elongated pallet runners each of which having an inner support structure integrally formed thereto. The plurality of elongated pallet runners each of which is adapted to be inserted into each of the respective plurality of pallet runner sleeves. A foldable side wall body is adapted to rest upon the foldable tray to form an interior space to receive a plurality of articles. The foldable side wall body comprises end walls, side walls, and side body flaps to form an enclosed bottom thereof. Each of the end walls includes an articulation fold formed therein so that during the collapsed position, the articulation folds move toward the interior space and during the constructed position, the articulation folds move away from the interior space. A lid is configured to telescopically enclosing the collapsible shipping container. | 12-22-2011 |
John D. Kari, Coeur D'Arlene, ID US
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20090175282 | Using a Transmission Control Protocol (TCP) Channel to Save Power for Virtual Private Networks (VPNs) That Use User Datagram Protocol (UDP) - Provided is a method for maintaining a Virtual Private Network (VPN) connection between a mobile device and a server over a wireless network in a manner that conserves the power supply of the mobile device and is suitable for connections that employ server-initiated traffic. After a successful login to a VPN server, a VPN client establishes a Transport Control Protocol (TCP) connection and a UDP connection with the server. After a power timeout, the server calculates the elapsed time between the current transmission and the last tunnel traffic. If the elapsed time exceeds a power timeout value, the VPN server transmits a simple control message to the client via the TCP channel. The client then reestablishes the UDP connection to the client and the server resumes transmission on the reestablished UDP channel. | 07-09-2009 |
20120287833 | Using a Transmission Control Protocol (TCP) Channel to Save Power for Virtual Private Networks (VPNs) That Use User Datagram Protocol (UDP) - Provided is a method for maintaining a Virtual Private Network (VPN) connection between a mobile device and a server over a wireless network in a manner that conserves the power supply of the mobile device and is suitable for connections that employ server-initiated traffic. After a successful login to a VPN server, a VPN client establishes a Transport Control Protocol (TCP) connection and a UDP connection with the server. After a power timeout, the server calculates the elapsed time between the current transmission and the last tunnel traffic. If the elapsed time exceeds a power timeout value, the VPN server transmits a simple control message to the client via the TCP channel. The client then reestablishes the UDP connection to the client and the server resumes transmission on the reestablished UDP channel. | 11-15-2012 |
John D. Kari, Coeur D'Alene, ID US
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20090031415 | Dynamic Network Tunnel Endpoint Selection - Dynamically selecting an endpoint for a tunnel into an enterprise computing infrastructure. A client dynamically selects a gateway (which may alternatively be referred to as a boundary device or server) as a tunnel endpoint for connecting over a public network (or, more generally, an untrusted network) into an enterprise computing infrastructure. The selection is made, in preferred embodiments, according to least-cost routing metrics pertaining to paths through the enterprise network from the selected gateway to a destination host. The least-cost routing metrics may be computed using factors such as the proximity of selectable tunnel endpoints to the destination host; stability or redundancy of network resources for this gateway; monetary costs of transmitting data over a path between the selectable tunnel endpoints and destination host; congestion on that path; hop count for that path; and/or latency or transmit time for data on that path. | 01-29-2009 |
20090133115 | VPN Management - A client attempts to transmit a presence state to a presence server that is behind a firewall of a secure network. If the client is inside the firewall, the presence server instructs resources within the secure network to directly communicate with the client. However, if the client is outside the firewall, then the client must tunnel into the secure network via a Virtual Private Network (VPN) before accessing the resources in the secure network. | 05-21-2009 |
20110083174 | Dynamic Network Tunnel Endpoint Selection - Dynamically selecting an endpoint for a tunnel into an enterprise computing infrastructure. A client dynamically selects a gateway (which may alternatively be referred to as a boundary device or server) as a tunnel endpoint for connecting over a public network (or, more generally, an untrusted network) into an enterprise computing infrastructure. The selection is made, in preferred embodiments, according to least-cost routing metrics pertaining to paths through the enterprise network from the selected gateway to a destination host. The least-cost routing metrics may be computed using factors such as the proximity of selectable tunnel endpoints to the destination host; stability or redundancy of network resources for this gateway; monetary costs of transmitting data over a path between the selectable tunnel endpoints and destination host; congestion on that path; hop count for that path; and/or latency or transmit time for data on that path. | 04-07-2011 |
Marianne Kari US
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20120113008 | ON-SCREEN KEYBOARD WITH HAPTIC EFFECTS - A computer-implemented method is described for displaying an on-screen keyboard on a touch-sensitive display of an electronic device is described. The method may detect contact of a finger in a contact area of the display and monitor movement of the contact area on display in response to movement of the finger across the display. The method may determine that the contact area is proximate a region of the display that includes a key of the on-screen keyboard, and provide a haptic effect to indicate that the finger is proximate the at least one key. The haptic effect may be provided via the display and be provided proximate to the detected contact area. In an example embodiment, an anchor on one or more keys of the on-screen keyboard is provides a further haptic effect to the finger when the finger is proximate to the anchor. | 05-10-2012 |
Robert Howard Kari, Ocoee, FL US
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20080236719 | Method of Manufacturing Luminescent Tiles and Products Made Therefrom - A method of manufacturing a luminescent tile for use in an aqueous environment includes admixing a luminescent pigment capable of being illuminated by an external light source, a forming material, and a catalyst to create a luminescent mixture. Casting the luminescent mixture into a mold and allowing said mixture to substantially harden thereby creating a luminescent tile. The forming material permits luminescence from the luminescent pigment upon excitation by an external light source, such as, a blacklight, while allowing the luminescent pigment to be safely used in an aqueous environment, such as a pool, spa, or the like. | 10-02-2008 |
20100096593 | Encapsulated luminescent particulates and aggregates made therefrom - An encapsulated luminescent particle for use in an aqueous environment includes a luminescent pigment capable of being illuminated by an external light source and an encapsulating material, wherein the encapsulated luminescent particles are between about 1.5 mm and about 5 mm in size. The encapsulating material permits luminescence from the luminescent pigment upon excitation by an external light source, such as, a blacklight, while allowing the luminescent pigment to be safely used in an aqueous environment, such as a pool, spa, or the like. | 04-22-2010 |
Ryan J. Kari, San Diego, CA US
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20080245159 | DEVICES AND METHODS FOR DETECTING RATES OF CHANGE OF TORQUE - Sensors for outputting signals indicative of a rate of change of torque experienced by a magnetized member in response to a change in torque experienced by the member are described. Such sensors include at least one sense element capable of detecting a change in a magnetic parameter of a magnetized region of the member positioned proximate to the sense element in response to a change in torque applied to the member. Devices for detecting and/or measuring rates of changes in or of torque that employ one or more of these sensors are also described, as are various applications for such devices. | 10-09-2008 |
20110181046 | DEVICES AND METHODS FOR DETECTING RATES OF CHANGE OF TORQUE - Sensors for outputting signals indicative of a rate of change of torque experienced by a magnetized member in response to a change in torque experienced by the member are described. Such sensors include at least one sense element capable of detecting a change in a magnetic parameter of a magnetized region of the member positioned proximate to the sense element in response to a change in torque applied to the member. Devices for detecting and/or measuring rates of changes in or of torque that employ one or more of these sensors are also described, as are various applications for such devices. | 07-28-2011 |
20140152236 | DEVICES AND METHODS FOR DETECTING RATES OF CHANGE OF TORQUE - Sensors for outputting signals indicative of a rate of change of torque experienced by a magnetized member in response to a change in torque experienced by the member are described. Such sensors include at least one sense element capable of detecting a change in a magnetic parameter of a magnetized region of the member positioned proximate to the sense element in response to a change in torque applied to the member. Devices for detecting and/or measuring rates of changes in or of torque that employ one or more of these sensors are also described, as are various applications for such devices. | 06-05-2014 |
Stuart Kari, Windsor, CA US
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20140277382 | Method for Manufacturing a Stent and Stent Manufactured Thereby - A method for manufacturing a stent includes forming a stent blank from a first material, the stent blank comprising a plurality of struts and a plurality of crowns, each crown connecting at least two struts, and a plurality of slots in at least some of the plurality of struts and/or the plurality of crowns, depositing a second material over outer surfaces of the struts and the crowns and in the slots to encase the stent blank in the second material, creating at least one opening through the second material, and removing the first material to form a stent comprising the second material, the stent having a continuous lumen from one end of the stent to the other end of the stent, the continuous lumen being partitioned in portions corresponding to the locations of the slots in the stent blank. The lumen may then be filled with a therapeutic substance. | 09-18-2014 |
Stuart Earl Kari, Windsor, CA US
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20090105809 | IMPLANTABLE AND LUMEN-SUPPORTING STENTS AND RELATED METHODS OF MANUFACTURE AND USE - An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns. Connections between adjacent segments are wider and stiffer than the struts and strut-crown transitions in the segments. The crowns include inner and outer radii with off-set centers along a common axis to provide medial crown peaks along the axis that are wider than the narrowed crown shoulders on either side of the axis and from which the tapered struts extend. Material strain and flexure along the stent during lateral bending is distributed mainly within the segments, e.g. along the struts or crowns, versus at the connections between segments. Material strain and deformation during radial expansion is principally concentrated at the crown shoulders and tapered transition region with the struts. Particular closed-open-closed arrangements along the stent length are disclosed, though with fewer stent connections in the relatively “closed” end-portions along the stent than are provided by other typically “open” cell stents in prior use. Enhanced combinations of performance characteristics are provided regarding visibility, trackability, expansion characteristics, fatigue failures, coating integrity, and local drug delivery from the stent. | 04-23-2009 |
20120197384 | IMPLANTABLE AND LUMEN-SUPPORTING STENTS AND RELATED METHODS OF MANUFACTURE AND USE - An implantable medical stent system, including a radially expandable stent including a filamental structure in a pattern surrounding a bore to form a substantially tubular wall along a length relative to a longitudinal axis; wherein the filamental structure includes at least one actuate crown with a crown peak having a radius of curvature located along a reference axis, and first and second arcuate crown shoulders on first and second sides, respectively, of the reference axis; and wherein the filamental structure also includes at least one pair of adjacent first and second elongated struts extending from the first and second crown shoulders, respectively. | 08-02-2012 |
Thomas Kari, Waseca, MN US
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20100304598 | Coaxial connector with coupling spring - The device includes an inner conductor, a dielectric material, an outer conductor, a coupling spring, and a sliding sleeve. The dielectric material surrounds the inner conductor. The outer conductor surrounds the dielectric material. The sliding sleeve is slidably attached to the outer conductor. The coupling spring is attached to the outer conductor. The coupling spring includes a plurality of beam tines. Each beam tine includes a lever tine. An adjacent pair of beam tines is separated by a slot where the slot has a root. A first distance is defined from the root to an edge of the beam tine. A second length is defined from the root to a distal end of the lever tine. The first length is greater than the second length. | 12-02-2010 |
U. Prasad Kari, Hatfield, PA US
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20110224153 | Asthma Associated Factors as Targets for Treating Atopic Allergies Including Asthma and Related Disorders - A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual. | 09-15-2011 |