Kappel, DE
Andreas Kappel, Koenigstein DE
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20100329977 | METHOD FOR IMAGING TUMOR TISSUE - A method is disclosed for imaging a tumor tissue, wherein in at least one embodiment a) the tumor tissue is contacted with a monoclonal antibody, an antigen-binding fragment thereof, a recombinant binding protein, an aptamer, or other molecule, each of which recognizes and binds at least one neoepitope which has been generated by proteolytic cleavage of proteins surrounding the tumor tissue by tumor-specific proteases, and b) the complexes formed from neoepitope and monoclonal antibody, antigen-binding fragment thereof, recombinant binding protein, aptamer, or other molecule are depicted with an imaging method, and also to neoepitopes generated by proteolytic cleavage of surrounding proteins by tumor-specific proteases, and also proteins or peptides for generating neoepitopes by tumor-specific proteases. | 12-30-2010 |
20110046455 | METHODS AND DEVICES FOR EXAMINING A PARTICULAR TISSUE VOLUME IN A BODY, AND A METHOD AND A DEVICE FOR SEGMENTING THE PARTICULAR TISSUE VOLUME - A tip of an elongate device is navigated into a particular tissue volume in order to examine the particular tissue volume in a body and part of the tissue volume is analyzed in real-time by way of a biosensor. In at least one embodiment, in the process, either the biosensor can be arranged on the tip of the device or the device includes a catheter, by which a substance to be analyzed is transported out of the tissue volume from the tip to the biosensor arranged at the proximal end of the catheter. | 02-24-2011 |
20110091918 | HETEROGENEOUS COAGULATION TEST - Within the field of coagulation diagnostics, in heterogeneous methods for determining the activity of blood coagulation factors and also in heterogeneous methods for determining anticoagulants which inhibit the activity of blood coagulation factors, a sample is contacted with a cleavable substrate, and the amount of uncleaved substrate is subsequently determined. | 04-21-2011 |
20120171697 | Method of Determining Inhibitors of Coagulation - A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined. | 07-05-2012 |
20120190052 | Method of determining factor XIII by means of NAD(P)H-analogues - The invention is in the field of in-vitro diagnostics and relates to a photometric method for determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of NAD(P)H analogues, and a test kit for carrying out the method. The invention is in the field of in-vitro diagnostics and relates to a photometric method for determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of NAD(P)H analogues, and a test kit for carrying out the method. | 07-26-2012 |
20120190053 | Method of determining factor XIII with the aid of plasma-based reference material - The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method. | 07-26-2012 |
20130323765 | Method For Determining The Activity Of A Proteolytic Coagulation Factor In A Sample - A method for determining the activity of a proteolytic coagulation factor in a sample may include (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) an agent for direct or indirect activation of the proteolytic coagulation factor in the sample, (iii) a cleavable substrate which has at least one cleavage site for the activated coagulation factor, (iv) a solid phase to which the cleavable substrate is bound or becomes bound during the incubation; (b) separating off the solid phase; and (c) determining the amount of solid-phase-bound, uncleaved substrate, wherein the determined amount of solid-phase-bound, uncleaved substrate indicates a quantitative measure of the activity of the proteolytic coagulation factor in the sample. | 12-05-2013 |
Andreas Kappel, Konigstein DE
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20100086953 | Blood Coagulation Assays - The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety. | 04-08-2010 |
20100240970 | METHOD FOR AN IN VIVO MEASUREMENT USING A DEVICE IMPLANTED IN A PATIENT, AND CORRESPONDING DEVICE - An embodiment of the present invention relates to a device, which can be implanted into a patient, for an in vivo measurement. In an embodiment, the device includes a catheter for guiding a sample of the patient town analysis unit in the device. A measurement result is determined in the analysis unit by analyzing the sample with the aid of a reagent. In an embodiment, the device furthermore includes an interchange chamber, with the aid of which the reagent can be removed from the device or can be inserted into the device. The interchange chamber has a connector allowing removal or insertion of the reagent while the device is implanted. | 09-23-2010 |
20100247438 | IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES - An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor. | 09-30-2010 |
Andreas Kappel, Glashütten DE
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20150184223 | METHOD FOR IMPROVED QUANTIFICATION OF MIRNAS - The invention relates to a method and kit for enriching miRNA nucleic acids molecules of interest in a sampe by selective removal of nucleic acid species, in particular miRNA species, which are not of interest. The invention is based on the surprizing and previously unknown information that only a few individual miRNA species make up the majority of all miRNA species in a sample. Selective removal of these species prior to detection of miRNA nucleic acids molecules will improve assay time, assay sensitivity, and reproducibility. | 07-02-2015 |
Andreas Kappel, Glasshutten DE
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20150037797 | IMMUNOASSAY FOR DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES SUCH AS MIRNAS - The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using an antibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest. | 02-05-2015 |
20150111772 | DIAGNOSTIC MIRNA PROFILES IN MULTIPLE SCLEROSIS - The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS. | 04-23-2015 |
Christoph Kappel, Aschheim DE
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20120142122 | METHOD OF INSPECTING AND PROCESSING SEMICONDUCTOR WAFERS - A wafer inspection method comprises imaging a full surface of the wafer at an imaging resolution insufficient to resolve individual microstructures which are repetitively arranged on the wafer. A mask | 06-07-2012 |
20130157391 | METHODS AND SYSTEMS FOR INSPECTING BONDED WAFERS - A method of inspecting a bonded wafer | 06-20-2013 |
Jochen Kappel, Gross-Gerau DE
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20150234725 | TESTING A VIRTUALIZED NETWORK FUNCTION IN A NETWORK - A method and system for testing a Virtualized Network Function (VNF) in a network. Metadata including test parameters pertaining to a network environment specific to the VNF is retrieved. At least one Virtualized Network Tester (VNT) for testing the VNF is created and stored in the network. The metadata is mapped to a test list to define a test suite of test cases based on the test parameters in the metadata. The VNF is tested by the at least one VNT according to the test suite to enable the at least one VNT to emulate the network environment specific to the VNF. The VNF is disconnected from the network and from virtual networks during the testing. If the testing is successful, the VNF is attached to the network and to virtual networks to enable the VNF to be deployed in the network. If the testing is unsuccessful, the method ends. | 08-20-2015 |
Marc Kappel, Hameln DE
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20150152607 | ROAD PAVER - The invention relates to a road paver comprising a chassis that carries a driver's cab, an undercarriage, at least one drive assembly, a hydraulic system, a cover mounted in an articulated manner, an asphalt feed arrangement comprising a storage hopper, a longitudinal conveyor device which conveys material from the storage hopper to a cross-distributor, and a steam suction system which is operated by means of a vacuum generator and comprises at least one suction flow path whose withdrawal line comprises a suction inlet above the cross-distributor and an outlet at a height above the driver's cab. At the suction inlet-side end of said withdrawal line, at least one confuser-like inlet nozzle is provided which is arranged to be secured to, and movable with, said cover, and which aspirates behind the cross-distributor in the travel direction such that accessibility in the region above the cross-distributor is not affected and the view out to the cross-distributor from the driver's cab is not obscured. | 06-04-2015 |
Markus Kappel, Roxheim DE
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20090067792 | Fiber-Optic Cable - Step-index optical waveguides are made of multicomponent glass containing a core glass and an outer glass which entirely surrounds the core class. A fiber-optic cable for conducting electromagnetic radiation, contains at least one bundle of individual fibers which encompass the step-index optical waveguides that are made of multicomponent glass containing a core glass and an outer glass that entirely surrounds the core glass on the circumferential wall thereof. These step-index optical waveguides provide great transmission capacity for transmitting data while keeping the transfer characteristics sufficiently durable. Furthermore, the fiber-optic cable is resistant against physical and chemical environmental influences and be protected against radical ambient chemicals. These aims are achieved by the fact that the outer glass of the step-index optical waveguides is provided with a material composition which is largely free from chemical interactions with the core glass when the fibers are drawn and is chemically inactive towards the plastic jacket. | 03-12-2009 |
20150049994 | SHEATHED OPTICAL WAVEGUIDE AND METHOD FOR PRODUCING IT - Sheathed optical waveguides and methods for producing such waveguides are provided. The sheathing is provided so that the fibers of the waveguides do not adhere to the sheathing. To this end, elastomeric material is formed into a tube surrounding a bundle of fibers and is solidified. The tube is prevented from radial compressing the fibers during solidification of the elastomeric material by a fluid in the tube. | 02-19-2015 |
Sebastian Kappel, Horb DE
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20100283595 | WEAR INDICATOR HAVING A TEMPERATURE SENSOR - In a braking system for a vehicle, having at least one brake pad, with which at least one wear indicator is possibly associated, at least one temperature sensor ( | 11-11-2010 |
Steffen Kappel, Bad Kreuznach DE
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20110209724 | METHOD AND DEVICE FOR TREATING CONTAINERS - The invention relates to a method and to a device for treating containers relating especially to cleaning plastic bottles ( | 09-01-2011 |
20120037190 | METHOD AND DEVICE FOR INTERNALLY CLEANING CANS HAVING CORRESPONDING OPENINGS - The present invention relates to a method and a device for internally cleaning cans ( | 02-16-2012 |
Steffen Kappel, Winzenheim DE
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20100037925 | ROTARY OR LINEAR BEVERAGE BOTTLE CLEANING MACHINE CONFIGURED TO CLEAN BEVERAGE BOTTLES DISPOSED UPSIDE-DOWN WHICH MACHINE INCLUDES APPARATUS FOR CLEANING ROTARY OR LINEAR BEVERAGE BOTTLE CLEANING MACHINE IN A FILLING PLANT AND ROTARY OR LINEAR CONTAINER CLEANING MACHINE CONFIGURED TO CLEAN CONTAINERS WITH APPARATUS FOR CLEANING THE CONTAINER CLEANING MACHINE - A rotary or linear beverage bottle cleaning machine configured to clean beverage bottles disposed upside-down which machine includes apparatus for cleaning rotary or linear beverage bottle cleaning machine in a filling plant and rotary or linear container cleaning machine configured to clean containers with apparatus for cleaning the container cleaning machine. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner. | 02-18-2010 |
20100071724 | METHOD OF CLEANING BEVERAGE BOTTLES IN A BEVERAGE BOTTLING PLANT, A METHOD OF CLEANING CONTAINERS IN A CONTAINER FILLING PLANT, AND AN APPARATUS THEREFOR - A method of cleaning beverage bottles in a beverage bottling plant, a method of cleaning containers in a container filling plant, and an apparatus therefor. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner. | 03-25-2010 |