Patent application number | Description | Published |
20080274186 | NELL-1 enhanced bone mineralization - Provided herein are methods for enhancing bone mineralization for bone repair or regeneration and compositions and grafts therefor. Methods for screening agents that enhance or modulate NELL-1 gene expression or NELL-1 protein production in a cell are also provided. | 11-06-2008 |
20090047275 | Nell-1 enhanced bone mineralization - The present invention provides Nell- | 02-19-2009 |
20090053311 | Pharmaceutical Compositions for Treating or Preventing Bone Conditions - Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same. | 02-26-2009 |
20090060988 | Nell-1 enhanced bone mineralization - The present invention provides Nell-1 genes and gene products and pharmaceutical compositions comprising the same that promote bone mineralization and osteoblast differentiation. The Nell-1 genes and gene products also represent targets for screening for modulators of bone mineralization and osteoblast differentiation. In addition, Nell-1-associated compounds and compositions can be used to increase bone density and facilitate repair of bone fractures. | 03-05-2009 |
20090087808 | Methods And Systems For Moving Teeth - Provided herein is a force system for repositioning teeth and the methods of making and using the system. | 04-02-2009 |
20090226505 | NELL Peptide Expression Systems and Bone Formation Activity of NELL Peptide - The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides. | 09-10-2009 |
20090239188 | TRANSDUCTION ORTHODONTIC DEVICES - Provided herein is a transduction cyclic force system for moving and/or repositioning teeth. | 09-24-2009 |
20090305184 | MECHANICAL TRANSDUCTION CYCLIC FORCE ORTHODONTIC SYSTEM - Provided herein is a transduction cyclic force system for moving and/or repositioning teeth. | 12-10-2009 |
20100136087 | Composition for Promoting Cartilage Formation or Repair Comprising a NELL Gene Product and Method of Treating Cartilage-Related Conditions Using Such Composition - Provided herein are a composition for promoting cartilage formation or regeneration comprising a NELL gene product and a method of treating cartilage-related conditions using such a composition. | 06-03-2010 |
20100137218 | Expression System of NELL Peptide - Recombinant NELL peptides and methods of preparing the same are disclosed. | 06-03-2010 |
20100249376 | NELL Peptide Expression Systems and Bone Formation Activity of NELL Peptide - The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides. | 09-30-2010 |
20110044956 | NELL-1 ENHANCED BONE MINERALIZATION - This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for modulators of bone mineralization. In addition, NELL-1 can be used to facilitate repair of bone fractures and/or to generally increase bone density. | 02-24-2011 |
20110212893 | NELL-1 ENHANCED BONE MINERALIZATION - Provided herein are methods for enhancing bone mineralization for bone repair or regeneration and compositions and grafts therefor. Methods for screening agents that enhance or modulate NELL-1 gene expression or NELL-1 protein production in a cell are also provided. | 09-01-2011 |
20110263835 | RECOMBINANT NELL PROTEIN PRODUCTION - The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a non-insect secretory signal peptide. | 10-27-2011 |
20110300184 | PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING BONE CONDITIONS - Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same. | 12-08-2011 |
20120065574 | ISOFORM NELL-1 PEPTIDE - This application generally relates to an isoform Nell-1 peptide, compositions thereof, and methods of using the same. | 03-15-2012 |
20120077742 | Expression System Of NELL Peptide - Recombinant NELL peptides and methods of preparing the same are disclosed. | 03-29-2012 |
20120171253 | Fibromodulin Peptide - Embodiments of the present invention provide a fibromodulin (FMOD) peptide (FMOD-P), a composition and a formulation comprising a FMOD-P, optionally with a TGF-β isoform, or comprising FMOD with a TGF-β isoform. The present invention also provides methods of making and using the FMOD-P, composition, or formulation. | 07-05-2012 |
20120220981 | Transcutaneous Multimodal Delivery System (TMDS) - A transcutaneous multimodal delivery device for drug delivery and the methods of making and using the same are provided. | 08-30-2012 |
20120237560 | Cardiac Compositions - Embodiments of the present invention provide a composition comprising perivascular stem cells or induced pluripotent cells (iPS) and a NELL-1 factor for cardiac or vascular regeneration and methods of making and using the same. | 09-20-2012 |
20120244128 | Perivascular Stem Cell Composition For Bone - Embodiments of the present invention provide an osteogenic composition comprising perivascular stem cells or induced pluripotent cells (iPS) and an osteogenic agent and methods of making and using the same. | 09-27-2012 |
20130078223 | Method And Composition For Inducing Human Pluripotent Stem Cells - The present invention provides pluripotent stem cell like (PSCL) cells or clones, a culture medium therefore, and a supernatant thereof, and methods of making and using the same. | 03-28-2013 |
20130309207 | COMPOSITIONS COMPRISING PERIVASCULAR STEM CELLS AND NELL-1 PROTEIN - Embodiments of the present invention provide a population of purified perivascular stem cells (PSC) or induced pluripotent stem cells (iPS) and a supernatant of stem cell free from the stem cell, a composition comprising any of these, and a method of using and making them. | 11-21-2013 |
20140105939 | METHODS AND COMPOSITIONS FOR MODULATING MYOFIBROBLAST ACTIVITIES - The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof | 04-17-2014 |
20140287018 | NANOPARTICLE-BASED SCAFFOLDS AND IMPLANTS, METHODS FOR MAKING THE SAME, AND APPLICATIONS THEREOF - Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery. | 09-25-2014 |
20140336367 | RECOMBINANT NEL-LIKE (NELL) PROTEIN PRODUCTION - The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a non-insect secretory signal peptide. | 11-13-2014 |
20140369971 | METHOD AND COMPOSITION FOR INDUCING HUMAN PLURIPOTENT STEM CELLS - The present invention provides a fibromodulin (FMOD) reprogrammed (FReP) cell and a method of making therefor, a culture medium therefor, and a supernatant thereof, and methods of making and using these. | 12-18-2014 |