Patent application number | Description | Published |
20100267350 | TUNING CIRCUITRY IN A COMMUNICATIONS DEVICE - A communications device is provided. The communications device includes a first antenna port coupled to a signal line, transmitter circuitry coupled to the signal line and configured to broadcast a radio frequency (RF) output signal across the first antenna port, tuning circuitry coupled to the signal line, and a controller configured to adjust a tuning of the tuning circuitry. The first antenna port, the transmitter circuitry, the tuning circuitry, and the controller are at least partially integrated on the same integrated circuit. | 10-21-2010 |
20100328542 | Low-Noise Amplifier Suitable for Use in a Television Receiver - A low-noise amplifier includes a first resistor that receives a first signal of a differential input signal, and a second resistor that receives a second signal of the differential input signal. The amplifier includes a first transconductance device coupled to the first resistor that provides a first signal of a differential output signal, and a second transconductance device coupled to the second resistor, that provides a second signal of the differential output signal. The receiver also includes a first capacitor coupled between the first resistor input and a control electrode on the second transconductance device, and a second capacitor coupled between the second resistor input and a control electrode on the first transconductance device. The low-noise amplifier can include additional gain stages. | 12-30-2010 |
20120326794 | DIGITAL AMPLITUDE CONTROL CIRCUITRY FOR CRYSTAL OSCILLATOR CIRCUITRY AND RELATED METHODS - Methods and systems are disclosed that utilize digital control loops to control an amplitude level for output signals generated by crystal oscillator circuitry. The disclosed embodiments utilize multiple selectable current drive circuits to control the amplitude level of the output signals from crystal oscillator circuitry. The current drive circuits are selectably used, or not used, to provide a bias current to the crystal oscillator circuitry based upon a multi-bit digital control signal. The multi-bit digital control signal can be generated, for example, by control circuitry that compares the oscillator output signal to a reference output signal level. | 12-27-2012 |
Patent application number | Description | Published |
20100322910 | METHODS OF OBTAINING ANTIGEN-SPECIFIC T CELL POPULATIONS - The invention provides a method of obtaining a population of antigen-specific T cells from peripheral blood of a host. An embodiment of the method of the invention comprises (i) dividing PBMCs from peripheral blood of a host into more than one sub-population; (ii) contacting the PBMCs with an antigen and IL-2; (iii) obtaining a sample of PBMCs from each sub-population; (iv) identifying an antigen-reactive sub-population by determining by high throughput quantitative PCR the expression of a factor produced by the PBMCs of each sample; (v) dividing the antigen-reactive sub-population into microcultures; (vi) identifying the antigen-reactive microculture; and (vii) expanding the microculture, thereby obtaining a population of T cells specific for the antigen. The invention also provides a population of T cells obtained by the inventive method, a pharmaceutical composition comprising the same, and a method of treating a disease in a host using the pharmaceutical composition. Related isolating and screening methods are further provided. | 12-23-2010 |
20130164272 | METHODS OF IDENTIFYING CENTRAL MEMORY T CELLS AND OBTAINING ANTIGEN-SPECIFIC T CELL POPULATIONS - The invention provides a method of obtaining a population of antigen-specific T cells comprising: (i) dividing PBMCs from peripheral blood of a host into more than one sub-population; (ii) contacting the PBMCs of each sub-population with an antigen; (iii) obtaining a sample of the contacted PBMCs from each sub-population; (iv) measuring the quantity of 1) IL-2 mRNA and 2) IFN-γ mRNA expressed by the PBMCs of each sample; (v) determining the IL-2 index of each sample; (vi) identifying one or more samples with an IL-2 index determined in (v) of greater than or equal to about 10 to identify one or more antigen-reactive, central memory T cell sub-populations; (vii) dividing the antigen-reactive, central memory T cell sub-population(s) identified in (vi) into microcultures; (viii) identifying one or more antigen-reactive microcultures; and (ix) expanding the microculture(s). | 06-27-2013 |
20140234353 | METHODS OF OBTAINING ANTIGEN-SPECIFIC T CELL POPULATIONS - The invention provides a method of obtaining a population of antigen-specific T cells from peripheral blood of a host. An embodiment of the method of the invention comprises (i) dividing PBMCs from peripheral blood of a host into more than one sub-population; (ii) contacting the PBMCs with an antigen and IL-2; (iii) obtaining a sample of PBMCs from each sub-population; (iv) identifying an antigen-reactive sub-population by determining by high throughput quantitative PCR the expression of a factor produced by the PBMCs of each sample; (v) dividing the antigen-reactive sub-population into microcultures; (vi) identifying the antigen-reactive microculture; and (vii) expanding the microculture, thereby obtaining a population of T cells specific for the antigen. The invention also provides a population of T cells obtained by the inventive method, a pharmaceutical composition comprising the same, and a method of treating a disease in a host using the pharmaceutical composition. Related isolating and screening methods are further provided. | 08-21-2014 |