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Kamens
Joanne Kamens, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110039914 | MODIFIED RNAI POLYNUCLEOTIDES AND USES THEREOF - The invention relates to improved RNAi constructs and uses thereof. The construct has a double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and preferably blunt-ended. The construct has selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the sense strand may be modified (e.g., one or both ends of the sense strand is/are modified by four 2′-O-methyl groups), such that the construct is not cleaved by Dicer or other RNAse III, and the entire length of the antisense strand is loaded into RISC. In addition, the antisense strand may also be modified by 2′-O-methyl group at the 2nd 5′-end nucleotide to greatly reduce off-target silencing. The constructs of the invention largely avoids the interferon response and sequence-independent apoptosis in mammalian cells, exhibits better serum stability, and enhanced target specificity. | 02-17-2011 |
Joanne S. Kamens, Newton Center, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080227704 | CXCL13 binding proteins - The present invention encompasses CXCL13 binding proteins. Specifically, the invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for CXCL13 and CXCL13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting mouse CXCL13 and for inhibiting mouse CXCL13 activity, e.g., in a mammal suffering from a disorder in which CXCL13 activity is detrimental. | 09-18-2008 |
Samuel N. Kamens, Highland Park, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090067414 | Systems and Methods for Communicating Documents - A system includes telephone and packet-switched network interfaces and a translator. The translator receives messages. Outgoing messages originate from a multiple-function peripheral (MFP) and are received via a transfer agent (TA). Outgoing e-mail messages include an attached file in an image file format. The translator removes and delivers the attachment in facsimile format. Incoming fax messages are attached to an e-mail message. The TA receives and relays the e-mail message to an identified MFP, which discards the e-mail message and prints the attachment. A method for processing fax messages includes associating an identifier with a MFP, receiving a fax intended for the MFP, generating an e-mail message with an attachment representing the fax and communicating the e-mail message to a transfer agent that relays the e-mail to the MFP, which discards the e-mail body and prints the attachment. | 03-12-2009 |
Samuel Nathan Kamens, Highland Park, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090067418 | Systems and Methods for Communicating Documents Via an Autonomous Multiple-Function Peripheral Device - A multiple-function peripheral device includes a packet-switched network interface and an autonomous application programming interface. The application programming interface requests image information from a remote server via the packet-switched network interface in a first mode of operation. The application programming interface sends image information to a remote device via the packet-switched network interface in a second mode of operation. | 03-12-2009 |
| 20100315683 | Systems and Methods for Communicating Documents Via an Autonomous Multiple-Function Peripheral Device - A multiple-function peripheral device includes a packet-switched network interface and an autonomous application programming interface. The application programming interface requests image information from a remote server via the packet-switched network interface in a first mode of operation. The application programming interface sends image information to a remote device via the packet-switched network interface in a second mode of operation. | 12-16-2010 |