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Kamen, US

Ali Kamen, Princeton, NJ US

Patent application numberDescriptionPublished
20100286517System and Method For Image Guided Prostate Cancer Needle Biopsy - In a method for image guided prostate cancer needle biopsy, a first registration is performed to match a first image of a prostate to a second image of the prostate. Third images of the prostate are acquired and compounded into a three-dimensional (3D) image. The prostate in the compounded 3D image is segmented to show its border. A second registration and then a third registration different from the second registration is performed on distance maps generated from the prostate borders of the first image and the compounded 3D image, wherein the first and second registrations are based on a biomechanical property of the prostate. A region of interest in the first image is mapped to the compounded 3D image or a fourth image of the prostate acquired with the second modality.11-11-2010
20100290685FUSION OF 3D VOLUMES WITH CT RECONSTRUCTION - A method for registration of ultrasound device in three dimensions to a C-arm scan, the method including acquiring a baseline volume, acquiring images in which the ultrasound device is disposed, locating the device within the images, registering the location of the device to the baseline volume, acquiring an ultrasound volume from the ultrasound device, registering the ultrasound volume to the baseline volume, and performing fusion imaging to display a view of the ultrasound device in the baseline volume.11-18-2010
20110026794Deformable 2D-3D Registration of Structure - A method for performing deformable non-rigid registration of 2D and 3D images of a vascular structure for assistance in surgical intervention includes acquiring 3D image data. An abdominal aorta is segmented from the 3D image data using graph-cut based segmentation to produce a segmentation mask. Centerlines are generated from the segmentation mask using a sequential topological thinning process. 3D graphs are generated from the centerlines. 2D image data is acquired. The 2D image data is segmented to produce a distance map. An energy function is defined based on the 3D graphs and the distance map. The energy function is minimized to perform non-rigid registration between the 3D image data and the 2D image data. The registration may be optimized.02-03-2011
20110040169INTEGRATION OF MICRO AND MACRO INFORMATION FOR BIOMEDICAL IMAGING - Macroscopic imaging data, such as from a CT, MR, PET, or SPECT scanner, is obtained. Microscopic imaging data of at least a portion of the same tissue is obtained. To align the microscopic imaging data with the macroscopic imaging data, intermediate data is also obtained. For example, photographic data is acquired at an intermediary stage of a process of preparing tissue for microscopic scan. The macroscopic and microscopic data are registered to the intermediary photographic data. Once registered to the intermediary data, the spatial relationship between the macroscopic and microscopic data is known and may be used for imaging or quantification.02-17-2011
20110122226SYSTEM AND METHOD FOR ROBUST 2D-3D IMAGE REGISTRATION - A method for registering 2-dimensional (2D) images with 3-dimensional (3D) images includes receiving a 2D reference image and a 3D moving image, initializing a registration parameter matrix that rigidly transforms the domain of the moving image, randomly sampling a set of registration parameter matrices in a neighborhood of the initial registration parameters, estimating a cost function for each of the randomly sampled parameter matrices, calculating a distance from each randomly sampled parameter matrix to the initial registration parameter matrix, calculating a mean shift vector from the estimated cost functions and distance, and updating the initial registration parameter matrix from the mean shift vector.05-26-2011
20110164035METHOD OF MOTION COMPENSATION FOR TRANS-CATHETER AORTIC VALVE IMPLANTATION07-07-2011
20110216954HIERARCHICAL ATLAS-BASED SEGMENTATION - A method for segmenting an image includes registering an annotated template image to an acquired reference image using only rigid transformations to define a transformation function relating the annotated template image to the acquired reference image. The defined transformation function is refined by registering the annotated template image to the acquired reference image using only affine transformations. The refined transformation function is further refined by registering the annotated template image to the acquired reference image using only multi-affine transformations. The twice refined transformation function is further refined by registering the annotated template image to the acquired reference image using deformation transformations.09-08-2011

Barton Kamen US

Patent application numberDescriptionPublished
20100009998Compositions and Methods Employing Aminopterin - The present invention relates to pharmaceutical compositions containing the antifolate aminopterin, processes for making the compositions, and methods of using them to treat disorders in adult and pediatric patients. Pharmaceutical compositions substantially free of impurities are provided comprising a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof. Relative to the teachings of the prior art, the disclosed methods and compositions provide unexpected improvements that include a greater interpatient oral bioavailability in pediatric patients, a smaller interpatient coefficient of variation of oral bioavailability, a smaller mean intrapatient coefficient of variation of oral bioavailability, a greater therapeutic index, a smaller coefficient of variation of toxicity, efficacy in combination therapy, and efficacy of certain polyglutamated metabolites.01-14-2010

Barton A. Kamen US

Patent application numberDescriptionPublished
20120128703Aminopterin Dosage Forms and Methods for Inflammatory Disorders - There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.05-24-2012

Dean L. Kamen, Bedford, NH US

Patent application numberDescriptionPublished
20080284130MULTIPLE-PASSENGER TRANSPORTER - A transporter for transporting a first person and one or more riders over a surface. The transporter includes a first support platform for supporting the first person, the first support platform having left and right sides and defining a fore-aft vertical plane and a lateral plane. At least one ground-contacting element is coupled to the first support platform such that the first support platform is capable of tilting in the fore-aft plane about a tilt axis. The at least one ground-contacting element is driven by a motorized drive arrangement so as to cause locomotion of the transporter. A controller commands the motorized drive arrangement. The controller is configured so that at least one of fore and aft sustained motion of the transporter is based at least on fore-aft tilting of the first support platform. One or more passenger platforms support one or more riders, the passenger platforms coupled to the first support platform such that fore-aft tilting of the first support platform is substantially independent of the one or more passenger platforms.11-20-2008
20080319627USER INPUT FOR VEHICLE CONTROL - A user input for controlling acceleration of a vehicle. The user input has a movable member capable of deflection by a user such that a degree of deflection corresponds to a specified velocity commanded by the user. The correspondence between the degree of deflection and the specified velocity may include a plurality of zones, each zone characterized by a distinct sensitivity that may be capable of customization for a specific user. The user input may also include a neutral position of the movable member, wherein a substantially sudden motion of the movable member to the neutral position causes a slewed slowing of the vehicle.12-25-2008
20100217497USER INPUT FOR VEHICLE CONTROL - A user input for controlling acceleration of a vehicle. The user input has a movable member capable of deflection by a user such that a degree of deflection corresponds to a specified velocity commanded by the user. The correspondence between the degree of deflection and the specified velocity may include a plurality of zones, each zone characterized by a distinct sensitivity that may be capable of customization for a specific user. The user input may also include a neutral position of the movable member, wherein a substantially sudden motion of the movable member to the neutral position causes a slewed slowing of the vehicle.08-26-2010
20110168467Hybrid Electric Vehicles Using a Stirling Engine - A personal vehicle for transporting a user over a surface including an external combustion engine. The vehicle includes a generator for converting the mechanical energy produced by the external combustion engine to electrical energy and an energy storage device for storing power provided by the generator and for providing power to the external combustion engine and the assembly. The personal vehicle includes a controller for controlling a total power load placed on the external combustion engine providing short term regulation of external combustion engine parameters.07-14-2011

Patent applications by Dean L. Kamen, Bedford, NH US

Douglas Kamen, Poughquag, NY US

Patent application numberDescriptionPublished
20110171241Stabilized Formulations Containing Anti-Interleukin-6 (IL-6) Antibodies - The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human interleukin-6 receptor (hIL-6R). The formulations may contain, in addition to an anti-hIL-6R antibody, at least one amino acid, at least one sugar, and/or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.07-14-2011

Paul Kamen, Berkeley, CA US

Patent application numberDescriptionPublished
20100013228SURFACE PIERCING TIDAL GENERATOR - A tidal generator includes a floating structure and a shaft that is supported over a moving body of water. The shaft is coupled to multiple rotors that have pitched blades that extend radially from the center of the rotor. Portions of the lower blades are submerged in the moving water. The movement of the water relative to the tidal generator causes the rotors and shaft to rotate. The shaft is coupled to an electrical generator.01-21-2010

Tamar Lara Kamen, New York, NY US

Patent application numberDescriptionPublished
20090280150Targeted And Individualized Cosmetic Delivery - A system and methods are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolated, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user. Targeted delivery of one or multiple skin benefit agents to the skin of a user may be achieved by applying and conforming to the skin a flexible cosmetic delivery sheet having associated therewith, on a first surface, one or multiple cosmetic treatment compositions provided in isolated, discrete regions, while an opposite surface of the sheet is provided with imprinted, predetermined regions corresponding to respective isolated, discrete regions on the first surface of the sheet. The user manipulates the sheet at the imprinted predetermined regions in a manner indicated by the imprinted predetermined regions to release one or multiple skin treatment compositions from the isolated, discrete regions and deliver effective amounts of one or multiple skin benefit agents to the targeted areas of the skin underlying the isolated, discrete regions of the sheet.11-12-2009
20100068247Method And System For Providing Targeted And Individualized Delivery Of Cosmetic Actives - A system and method are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolate, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user.03-18-2010

Yavok Kamen, Cupertino, CA US