Patent application number | Description | Published |
20110172392 | METHOD FOR PRODUCING PEPTIDE - The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an —SMe group; (b) allowing the —SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b). | 07-14-2011 |
20110262945 | GLYCOPROTEIN PRODUCTION METHOD AND SCREENING METHOD - A method for producing a glycoprotein, which is uniform in terms of functions derived from a sugar chain (e.g., a blood half-life) and physiological activities, i.e., a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure and the higher-order structure; specifically, a method for producing a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure, and the higher-order structure, includes the following steps (a) to (c): (a) folding a glycoprotein, which is uniform in terms of the amino acid sequence and the sugar chain structure; (b) fractionating the folded glycoprotein by column chromatography; and (c) collecting a fraction having a specified activity. | 10-27-2011 |
20110313136 | IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING THE SAME - A full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto, and a process for producing the full-length IgG-Fc fragment. Specifically, an IgG-Fc fragment has a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1st to 30th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met reside is substituted by an amino acid reside other than a Met residue. | 12-22-2011 |
20120035345 | PROCESS FOR PREPARING GLYCOPEPTIDES HAVING ASPARAGINE-LINKED OLIGOSACCHARIDES, AND THE GLYCOPEPTIDES - Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain obtained by:
| 02-09-2012 |
20120114595 | SUGAR CHAIN-ADDED AILIM EXTRACELLULAR DOMAIN AND METHOD FOR PRODUCING SAME - Disclosed is a synthetic AILIM extracellular domain which has high ligand-binding ability and a quality sufficient for a pharmaceutical product. Also disclosed is a method for synthesizing the synthetic AILIM extracellular domain. Specifically disclosed is a sugar chaim-added AILIM extracellular domain wherein a sugar chain is bound at a position corresponding to the 69-position of the amino acid sequence of human AILIM extracellular domain, said amino acid sequence being depicted in SEQ ID NO: 7, and no sugar chain is added at positions corresponding to the 3-position and the 90-position of the amino acid sequence. | 05-10-2012 |
20120264684 | Glycosylated Form of Antigenic GLP-1 Analogue - Disclosed is a glucagon-like peptide-1 (GLP-1) analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity. Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid. | 10-18-2012 |
20140058062 | Method for Producing Glycopeptide Having Sialyl Sugar Chain, Sialyl Sugar Chain-Added Amino Acid Derivative to be Used in Same, and Glycopeptide - [Technical Promblem] | 02-27-2014 |
20140235822 | METHOD FOR PRODUCING PEPTIDE - The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b). | 08-21-2014 |
20140249294 | PROCESS FOR PRODUCTION OF PEPTIDE THIOESTER - A process for chemically converting a peptide chain into a peptide thioester includes, when a —C(═X)—R | 09-04-2014 |
20140369964 | GLYCOSYLATED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME - The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments. | 12-18-2014 |
20140377807 | METHOD FOR PRODUCING POLYPEPTIDE FRAGMENT WITH HIGH EFFICIENCY, WHICH IS SUITABLE FOR NCL METHOD - A method for efficiently manufacturing a polypeptide fragment suitable for the NCL method includes a step of reacting a polypeptide containing a first polypeptide fragment having cysteine at the N-terminal and a second polypeptide fragment linked via an intervening sequence -Cys-W-(His)n-Z-Met- with CNBr to obtain a first polypeptide fragment having cysteine at the N-terminal and a third polypeptide fragment, and a step of sequentially reacting the third polypeptide fragment with a compound represented by the following formula (I) and a compound represented by the following formula (II) to obtain a second polypeptide fragment having the C-terminal modified. | 12-25-2014 |
Patent application number | Description | Published |
20080212800 | Diaphragm for Speaker, Method for Producing Same, Speaker Using Such Diaphragm, and Apparatus Using Such Speaker - A diaphragm for a loudspeaker contains resin, aramid fibers, and an organic silicon compound binding the resin with the aramid fibers. By this structure, high elasticity and high internal loss as characteristics of the aramid fibers are maintained; flexibility in the setting of properties of the diaphragm is thus increased. Accordingly, a diaphragm securing humidity resistance reliability and strength, and having a superior appearance can be provided. | 09-04-2008 |
20100059309 | DIAPHRAGM FOR SPEAKER, FRAME FOR SPEAKER, DUST CAP FOR SPEAKER, SPEAKER AND APPARATUS USING THEM, AND METHOD FOR MANUFACTURING COMPONENT FOR SPEAKER - A speaker diaphragm is configured by a compound mixed with resin and bamboo fiber. The diaphragm satisfying the advantage of the bamboo fiber of high sound quality and a large degree of freedom in the setting of the characteristic value of the diaphragm and the advantage of the diaphragm made of a resin with improved humidity resistance reliability and strength, excellent external appearance, and enhanced productivity and dimension stability is obtained. | 03-11-2010 |
20100074463 | MATERIAL FOR SPEAKER DEVICE AND A SPEAKER DEVICE USING IT - A material for improving the sound pressure level at the bass reproduction limit of the present invention is composed of an activated carbon having a cumulative pore volume of 0.4 ml/g or more for the pores each having a radius of 50 angstroms or less. Preferably, this activated carbon has a cumulative pore volume of 0.1 ml/g or less for the pores each having a radius of 7 angstroms or less. In particular, when a sound pressure level improving material in which the activated carbon has a cumulative pore volume of 0.5 ml/g or more for the pores each having a radius of 18 angstroms or less is installed in a cabinet of a loudspeaker device, the material alleviates pressure fluctuations of a gas within the cabinet caused by vibration of a loudspeaker, and thus a very good bass reproduction effect is attained. Moreover, in the case where a sound pressure level improving material in which the activated carbon has a cumulative pore volume of 0.4 ml/g or more for the pores each having a radius of 18 to 50 angstroms is installed in the cabinet, a loudspeaker device having a good bass reproduction effect even in an atmosphere of high humidity is obtained. | 03-25-2010 |
20100150389 | SPEAKER, SPEAKER DEVICE USING THE SAME AND ELECTRONIC APPARATUS AND VEHICLE USING THE SPEAKER - According to the present invention, there is provided a speaker for use in audio/video apparatuses and a small-sized speaker device capable of realizing preferable reproduction a bass sounds. In order to attain this, in the present invention, a pressure adjusting body is coupled to a portion of a magnetic circuit or a frame, which is a component of a speaker unit, to constitute the speaker unit. The speaker unit is mounted to a small-sized cabinet to constitute a speaker device, which enables realization of preferable reproduction of bass sounds. | 06-17-2010 |
20100172533 | DIAPHRAGM FOR SPEAKER, SPEAKER USING THE DIAPHRAGM, AND SYSTEM USING THE SPEAKER - A loudspeaker diaphragm contains polylactic acid, and bamboo charcoal mixed in the polylactic acid. The diaphragm does not affect environment and provides a loudspeaker with high sound quality. | 07-08-2010 |
20110164764 | DIAPHRAGM FOR SPEAKER, SPEAKER USING THE DIAPHRAGM, ELECTRONIC DEVICE USING THE SPEAKER, AND SPEAKER-MOUNTED DEVICE - A speaker diaphragm containing resin and carbonized bamboo material with a large degree of flexibility in setting physical properties, moisture-proof reliability and strength secured, superior appearance, and productivity and dimensional stability increased, which allows making characteristics and sound highly accurately, and designing with great originality. | 07-07-2011 |
20120112382 | DIAPHRAGM FOR SPEAKER, FRAME FOR SPEAKER, DUST CAP FOR SPEAKER, SPEAKER AND APPARATUS USING THEM, AND METHOD FOR MANUFACTURING COMPONENT FOR SPEAKER - A speaker diaphragm is configured by a compound mixed with resin and bamboo fiber. The diaphragm satisfying the advantage of the bamboo fiber of high sound quality and a large degree of freedom in the setting of the characteristic value of the diaphragm and the advantage of the diaphragm made of a resin with improved humidity resistance reliability and strength, excellent external appearance, and enhanced productivity and dimension stability is obtained. | 05-10-2012 |
20120114149 | DIAPHRAGM FOR SPEAKER, FRAME FOR SPEAKER, DUST CAP FOR SPEAKER, SPEAKER AND APPARATUS USING THEM, AND METHOD FOR MANUFACTURING COMPONENT FOR SPEAKER - A speaker diaphragm is configured by a compound mixed with resin and bamboo fiber. The diaphragm satisfying the advantage of the bamboo fiber of high sound quality and a large degree of freedom in the setting of the characteristic value of the diaphragm and the advantage of the diaphragm made of a resin with improved humidity resistance reliability and strength, excellent external appearance, and enhanced productivity and dimension stability is obtained. | 05-10-2012 |
20120114165 | DIAPHRAGM FOR SPEAKER, FRAME FOR SPEAKER, DUST CAP FOR SPEAKER, SPEAKER AND APPARATUS USING THEM, AND METHOD FOR MANUFACTURING COMPONENT FOR SPEAKER - A speaker diaphragm is configured by a compound mixed with resin and bamboo fiber. The diaphragm satisfying the advantage of the bamboo fiber of high sound quality and a large degree of freedom in the setting of the characteristic value of the diaphragm and the advantage of the diaphragm made of a resin with improved humidity resistance reliability and strength, excellent external appearance, and enhanced productivity and dimension stability is obtained. | 05-10-2012 |