Patent application number | Description | Published |
20080305092 | Methods of treating autoimmune disease via CTLA-4IG - The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of activated T cell lymphokine production occurs upon stimulatory binding of the CD28 surface receptor molecule, even in the presence of conventional immunosuppressants. Inhibition of CD28 receptor binding to an appropriate stimulatory ligand or inactivation of the CD28 signal transduction pathway through other means down-regulates CD28-pathway related T cell lymphokine production and its resulting effects. | 12-11-2008 |
20090155836 | METHODS FOR TREATING HIV INFECTED SUBJECTS - Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis. | 06-18-2009 |
20100061958 | Modulation of Regulatory T Cells by Human IL-18 - The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject. | 03-11-2010 |
20110262467 | Novel Artificial Antigen Presenting Cells and Uses Therefor - The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit. | 10-27-2011 |
20110268752 | Inducible Regulatory T-Cell Generation for Hematopoietic Transplants - The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases. | 11-03-2011 |
20120034249 | Methods for Treating Progressive Multifocal Leukoencephalopathy (PML) - The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes. | 02-09-2012 |
20120064033 | MODULATION OF REGULATORY T CELLS BY HUMAN IL-18 - The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject. | 03-15-2012 |
20120263693 | Methods for Treating Progressive Multifocal Leukoencephalopathy (PML) - The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes. | 10-18-2012 |
20130071409 | ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells - The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents. | 03-21-2013 |
20130101567 | Methods to Expand a T Regulatory Cell Master Cell Bank - Compositions and methods for expanding natural T regulatory cells (nTregs) without substantially sacrificing suppressive function of the cells are disclosed. Also provided are uses of the expanded nTregs for cellular therapy. | 04-25-2013 |
20130287748 | Use of Chimeric Antigen Receptor-Modified T-Cells to Treat Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 10-31-2013 |
20130288368 | Compositions for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 10-31-2013 |
20130309258 | Methods for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 11-21-2013 |
20140099309 | Use of a Trans-Signaling Approach in Chimeric Antigen Receptors - The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation. | 04-10-2014 |
20140099340 | Compositions and Methods for Targeting Stromal Cells for the Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain. | 04-10-2014 |
20140106449 | Use of Chimeric Antigen Receptor-Modified T Cells to Treat Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 04-17-2014 |
20140186947 | Activation and Expansion of T-Cells Using an Engineered Multivalent Signaling Platform as a Research Tool - Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon. | 07-03-2014 |
20140212446 | Novel Artificial Antigen Presenting Cells and Uses Thereof - The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit. | 07-31-2014 |
20140219975 | SWITCH COSTIMULATORY RECEPTORS - The present invention relates generally to a fusion protein that when displayed on a cell can convert a negative signal into a positive signal in the cell. The fusion protein is a chimeric protein in that the protein comprises at least two domains, wherein the first domain is a polypeptide that is associated with a negative signal and the second domain is a polypeptide that is associated with a positive signal. Thus, the invention encompasses switch receptors that are able to switch negative signals to positive signals for enhancement of an immune response. | 08-07-2014 |
20140271635 | TREATMENT OF CANCER USING HUMANIZED ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of CD19. The invention also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain. | 09-18-2014 |
20140322212 | EFFECTIVE TARGETING OF PRIMARY HUMAN LEUKEMIA USING ANTI-CD123 CHIMERIC ANTIGEN RECEPTOR ENGINEERED T CELLS - The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant. | 10-30-2014 |
20140322275 | TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain. | 10-30-2014 |
20140370017 | Methods for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 12-18-2014 |
20140370045 | USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions. | 12-18-2014 |
20150017141 | USE OF ICOS-BASED CARS TO ENHANCE ANTITUMOR ACTIVITY AND CAR PERSISTENCE - The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain. | 01-15-2015 |
20150024482 | Compositions and Methods for Generating a Persisting Population of T Cells Useful for the Treatment of Cancer - The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells. | 01-22-2015 |
20150050729 | Compositions for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 02-19-2015 |
20150093822 | Compositions for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 04-02-2015 |
20150099299 | Compositions for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 04-09-2015 |
20150118202 | Methods for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain | 04-30-2015 |
20150140019 | Compositions and Methods for Regulating CAR T Cells - The present invention provides compositions and methods for inhibiting the depletion of healthy tissue during CAR T cell therapy. In another embodiment, the invention includes a drug-molecule conjugate which is administered to a subject receiving CAR T cell therapy, where the conjugate binds to the CAR resulting in internalization of the conjugate and inhibition of T cell activity and/or death of the T cell. | 05-21-2015 |
20150190428 | Methods for Assessing the Suitability of Transduced T Cells for Administration - The invention relates to of analyzing vector supernatants useful for transducing T cells destined for administration to a human subject. The invention also related to methods of analyzing transduced T cells destined for administration to a human subject. | 07-09-2015 |
20150202286 | Toxicity Management for Anti-Tumor Activity of CARs - The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient. | 07-23-2015 |
20150283178 | TREATMENT OF CANCER USING ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein. | 10-08-2015 |
20150290244 | USE OF CART19 TO DEPLETE NORMAL B CELLS TO INDUCE TOLERANCE - The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 10-15-2015 |
20150322169 | Enhancing Activity of CAR T Cells by Co-Introducing a Bispecific Antibody - The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof. | 11-12-2015 |
20150342994 | ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells - The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents. | 12-03-2015 |
20160000829 | METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) - The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes. | 01-07-2016 |
20160046724 | TREATMENT OF CANCER USING HUMANIZED ANTI-BCMA CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain. | 02-18-2016 |
Patent application number | Description | Published |
20100101800 | Subsea Completion with a Wellhead Annulus Access Adapter - A subsea completion assembly for a subsea well including installed casing and a wellhead. The assembly includes a production casing forming a B annulus between the outside of the production casing and the installed casing. The assembly also includes an annulus access adapter installed in the wellhead, the adapter including a manipulatable valve controlling fluid communication with the fluid in the B annulus across the annulus access adapter. A property of the fluid in the B annulus can be monitored by fluid communicated across the annulus access adapter. | 04-29-2010 |
20100229981 | SELF-SEALING HYDRAULIC CONTROL LINE COUPLING - There is provided a hydraulic fluid control line connector including first and second couplings configured to automatically seal shut when the members are disengaged. There is further provided a method for blocking contamination or pressure transfer of hydraulic fluid control lines by securing first and second couplings to corresponding ends of a hydraulic line and automatically sealing the couplings shut when the couplings are disengaged. | 09-16-2010 |
20100294492 | Function Spool - A production assembly and method for controlling production from production tubing supported by a tubing hanger in a well including a wellhead. The assembly includes a function spool engaged with the wellhead and a tree engaged with the function spool. The tubing hanger is landable in the tree bore such that the production tubing is supported in the well by the tree. A function mandrel separate from the tubing hanger is engaged with the production tubing and positionable inside the function spool bore. The function mandrel includes a passage connected to a line extending into the well that is connectable with a port in the function spool such that communication with a downhole component through the line is allowable from outside the function spool. | 11-25-2010 |
20110017467 | Multi-Section Tree Completion System - A subsea well production system for a well including a subsea wellhead. The system includes a multi-section production tree that includes a landing section engageable with the subsea wellhead and including a landing section bore. The tree also includes a valve section separate from and engageable with the landing section, the valve section including a lateral production port extending through a valve section wall and in communication with a valve section bore. A production tubing supported by a tubing hanger is installed and supported in the landing section bore such that the tubing hanger extends into the valve section bore. The tubing hanger and production tubing are retrievable through the section bores without disengaging the valve section from the landing section. The valve section is also disengageable from the landing section with the tubing hanger remaining in the landing section. | 01-27-2011 |
20110108279 | SELF-SEALING CHEMICAL INJECTION LINE COUPLING - There is provided a chemical injection line connector including first and second couplings configured to automatically seal shut when the members are disengaged. There is further provided a method for blocking contamination or pressure transfer of chemical injection lines by securing first and second couplings to corresponding ends of a chemical injection line and automatically sealing the couplings shut when the couplings are disengaged. | 05-12-2011 |
20130092248 | SELF-SEALING HYDRAULIC CONTROL LINE COUPLING - There is provided a hydraulic fluid control line connector including first and second couplings configured to automatically seal shut when the members are disengaged. There is further provided a method for blocking contamination or pressure transfer of hydraulic fluid control lines by securing first and second couplings to corresponding ends of a hydraulic line and automatically sealing the couplings shut when the couplings are disengaged. | 04-18-2013 |
20130118601 | SELF-SEALING CHEMICAL INJECTION LINE COUPLING - There is provided a chemical injection line connector including first and second couplings configured to automatically seal shut when the members are disengaged. There is further provided a method for blocking contamination or pressure transfer of chemical injection lines by securing first and second couplings to corresponding ends of a chemical injection line and automatically sealing the couplings shut when the couplings are disengaged. | 05-16-2013 |
20130248200 | Function Spool - A production assembly and method for controlling production from production tubing supported by a tubing hanger in a well including a wellhead. The assembly includes a function spool engaged with the wellhead and a tree engaged with the function spool. The tubing hanger is landable in the tree bore such that the production tubing is supported in the well by the tree. A function mandrel separate from the tubing hanger is engaged with the production tubing and positionable inside the function spool bore. The function mandrel includes a passage connected to a line extending into the well that is connectable with a port in the function spool such that communication with a downhole component through the line is allowable from outside the function spool. | 09-26-2013 |
20140048277 | SUBSEA PRODUCTION SYSTEM WITH DOWNHOLE EQUIPMENT SUSPENSION SYSTEM - A subsea production system for a well including a subsea production tree, a tubing hanger, and a production tubing extending into the well and supported by the tubing hanger. A downhole equipment suspension system includes a suspension head supported directly or indirectly by the production tree above and separately from the tubing hanger. The suspension system also includes downhole equipment inside the production tubing below the tubing hanger and a suspension line extending through the tubing hanger vertical production bore and the production tree vertical bore. The suspension line suspends the downhole equipment from the suspension head. | 02-20-2014 |
20140158366 | Subsea Completion With a Tubing Spool Connection System - A subsea completion for a well is presented that includes a tubing spool, a tubing hanger, a fluid coupling, an electrical coupling, a control system, a valve, and a production tree. The tubing spool includes a central bore, a side wall, and a fluid supply passage extending through the tubing spool. An electrical supply passage can also extend through the side wall of the tubing spool. The tubing hanger includes a fluid control passage. The tubing hanger can also include an electrical control passage. The control system includes a fluid control conduit to provide fluid to the tubing spool fluid supply passage from outside the tubing spool. The valve is connectable to the outside of the tubing spool to control fluid flow between the control system fluid conduit and the tubing spool fluid supply passage. | 06-12-2014 |
20140332223 | Modular Subsea Completion - A system for producing well production fluids through a tubing hanger connected with a tubing string, in certain embodiments, includes a subsea tree and a tubing spool. The subsea tree includes a production flow passage, and the tubing spool includes a longitudinal bore configured to receive the tubing hanger and a lateral production flow passage configured to transfer well production fluids to the production flow passage of the subsea tree. The subsea tree and the tubing spool are configured to be run and retrieved independently of one another in any order. | 11-13-2014 |
20150053412 | Production System Including Tubing Hanger with Valve - A subsea completion system for a subsea well includes a tubing spool including an internal bore formed therethrough and a tubing hanger movable into a landed position within the internal bore of the tubing spool. The tubing hanger includes a production bore formed therethrough, an auxiliary passage formed therethrough outside of the production bore, and a valve in fluid communication with the auxiliary passage to control the flow of fluid through the auxiliary passage. | 02-26-2015 |
20150259990 | Tubing Hanger Orientation Spool - A subsea well installation assembly for installing a tubing hanger in a subsea well includes a spool with a spool orientation feature and a running tool connectable to the tubing hanger with a running tool orientation feature. The tubing hanger is rotatable to the predetermined orientation by movement of the running tool with respect to the spool such that the running tool orientation feature engages the spool orientation feature, and the tubing hanger is landable in the predetermined orientation by movement of the running tool with respect to the spool such that the running tool orientation feature engages the spool orientation feature. | 09-17-2015 |
20150330194 | Downhole Equipment Suspension and Power System Background - A subsea production system for a subsea well including a tubing hanger to suspend production tubing extending into the subsea well. Downhole equipment is locatable inside the production tubing in the subsea well. The system includes an adaptor spool including an internal bore. A suspension apparatus is supportable above the tubing hanger and within the internal bore of the adaptor spool. A power penetrator is laterally coupleable to the suspension apparatus. A suspension line is extendable from the suspension apparatus to suspend the downhole equipment. A communication line is extendable from the suspension apparatus to provide power to the downhole equipment. | 11-19-2015 |
20150354308 | Downhole Equipment Suspension and Lateral Power System - A downhole equipment suspension and lateral power system for a subsea well including a suspension apparatus which is supportable above the tubing hanger and within the internal bore of the subsea production system. A power penetrator is laterally coupleable to the suspension apparatus. A cable is extendable from the suspension apparatus to suspend and power downhole equipment, such as an electric submersible pump. A communication line is extendable from the suspension apparatus to provide power to the downhole equipment. | 12-10-2015 |
20160024878 | System and Method for Accessing a Well - A system and method for accessing a well, in certain embodiments, includes a production tree, a cap, and a spool including a longitudinal bore configured to receive a tubing hanger. The tubing hanger includes a longitudinal bore configured to transfer product between the spool and the production tree. At least one adjustable fluid barrier is included in the tubing hanger and/or the cap. The adjustable fluid barrier can be used to open and close the longitudinal passage and allow access through the tubing hanger and/or the cap. | 01-28-2016 |
Patent application number | Description | Published |
20090116190 | Controlling Airflow In A Computer Chassis - Computer chassis configured for controlled airflow including at least one component board; a segmented curtain suspended across a region of airflow in the computer chassis above the component board; and at least one component mounted on the component board displacing at least one segment of the segmented curtain creating an airflow channel under the displaced segment. Segmented curtains for controlling airflow in a computer chassis including one or more segments capable of being displaced by components mounted on a component board in the computer chassis; and one or more fasteners for suspending the segmented curtain across a region of airflow in the computer chassis. Controlling airflow in a computer chassis including inserting a component board into the computer chassis; displacing, a segment of a segmented curtain thereby creating an airflow channel; and providing airflow through the airflow channel created by the displacement of the segment of the segmented curtain. | 05-07-2009 |
20110044008 | TOP ACTUATED, FORCE LIMITING HEATSINK RETENTION SYSTEM - Apparatus for securing or retaining a heatsink. The heatsink retention apparatus includes a heatsink module that cooperates with first and second spring loaded latches secure to a circuit board on opposing sides of a heat-generating component. The heatsink module includes a handle pivotally secured to opposing sides of the heatsink body, and bails pivotally secured to the handle. In addition, the bails extend downward to dispose a lower bail member adjacent the spring loaded latches. As the handle pivots between a first position to raise the bails and a second position to lower the bails, the bails automatically move from a locked position to an unlocked position. Each of the spring loaded latches include a hook and at least one pre-loaded spring to transfer a minimum downforce to the lower bail members when the bails are raised. Accordingly, embodiments may be operated from the top of the heatsink without the use of tools, while providing a desired downforce over a range of heatsink heights. | 02-24-2011 |
20110250047 | Airflow From A Blower With One Or More Adjustable Guide Vanes That Are Affixed To The Blower At One Or More Pivot Points Located In An Outlet Of The Blower - Methods, apparatus, and products are disclosed for improving the airflow exiting a blower that has one or more adjustable guide vanes that are affixed to the blower at one or more pivot points located in an outlet of the blower that include: determining a rotational speed of an impeller in the blower and adjusting a position of at least one of the adjustable guide vanes in dependence upon the rotational speed of the impeller. | 10-13-2011 |
20110250048 | Airflow From A Blower With One Or More Adjustable Guide Vanes That Are Affixed To The Blower At One Or More Pivot Points Located In An Outlet Of The Blower - Methods, apparatus, and products are disclosed for improving the airflow exiting a blower that has one or more adjustable guide vanes that are affixed to the blower at one or more pivot points located in an outlet of the blower that include: determining a rotational speed of an impeller in the blower and adjusting a position of at least one of the adjustable guide vanes in dependence upon the rotational speed of the impeller. | 10-13-2011 |
20110250049 | Airflow From A Blower With One Or More Adjustable Guide Vanes That Are Affixed To The Blower At One Or More Pivot Points Located In An Outlet Of The Blower - Methods, apparatus, and products are disclosed for improving the airflow exiting a blower that has one or more adjustable guide vanes that are affixed to the blower at one or more pivot points located in an outlet of the blower that include: determining a rotational speed of an impeller in the blower and adjusting a position of at least one of the adjustable guide vanes in dependence upon the rotational speed of the impeller. | 10-13-2011 |
20110292593 | INDEPENDENTLY OPERABLE IONIC AIR MOVING DEVICES FOR ZONAL CONTROL OF AIR FLOW THROUGH A CHASSIS - Airflow in a computer chassis may be enhanced or reduced to affect cooling of heat generating devices using an ionic air moving device. A plurality of ionic air moving devices enhance or reduce airflow through a plurality of fluidically parallel airflow zones of the computer chassis in an airflow direction established by a nonionic air moving device. Each ionic air moving device comprises an ion emitter electrode disposed a spaced distance from a collector electrode, wherein a controller independently controls an electrical potential between the emitter and collector electrodes of each ionic air moving device for affecting the rate of airflow through one or more of the plurality of airflow zones. | 12-01-2011 |
20120036998 | ELECTROSTATIC CONTROL OF AIR FLOW TO THE INLET OPENING OF AN AXIAL FAN - An air moving apparatus comprises an axial fan and an electrostatic device. The axial fan has a rotatable shaft defining a central axis of the axial fan, a plurality of blades secured to the shaft, and an air inlet opening. The electrostatic device is disposed immediately upstream of the air inlet opening of the axial fan, and includes a collector and an emitter. In one embodiment, the electrostatic device comprises a cylindrical collector coupled to ground and has a central axis aligned with the central axis of the axial fan, wherein the cylindrical collector has an inner diameter that is substantially the same as the diameter of an air inlet opening to the axial fan. The electrostatic device further comprises a plurality of emitter wires coupled to a terminal of a direct current source and extending lengthwise within the cylindrical collector. The axial fan moves air longitudinally through an air inlet opening of the axial fan, and, during operation of the axial fan, the application of an electrical potential between an emitter and a collector causes ionic air movement radially outwardly away from a central axis of the axial fan. | 02-16-2012 |
20130133859 | HEAT SINK WITH HEAT BUS AND FIN STRUCTURE - A heat sink to remove heat from a processor within a chassis to air moving through a fin structure on the heat sink. An embodiment of the heat sink comprises a heat bus engaging the processor to conduct heat from the processor to a fin structure having interconnected, repeating cellular air channels. A U-shaped heat bus comprises a base and first and second legs extending therefrom connected to opposite sides of the fin structure. An embodiment of the heat bus has a solid conductive core to conductively transfer heat from the processor through the base and the first and second legs to sides of the fin structure. Alternately, an embodiment of the heat bus has a hollow core containing a fluid to evaporatively transfer heat from the processor through the base and the first and second legs to sides of the fin structure. | 05-30-2013 |
20130138262 | HEAT SINK WITH ORIENTABLE FINS - A heat sink comprises a plurality of fins that may be positioned in a plurality of orientations relative to a heat-generating electronic component to which the heat sink is thermally coupled. A controller may be used to detect an elevated processor temperature and to activate a drive member to automatically adjust the orientation of fins on the heat sink. The fins may be moved and aligned with an air flow made over the heat sink. The adjustable-fin heat sink affords added flexibility in arranging a processor or other heat-generating electronic component on a circuit board. The orientation or position of the heat sink fins may also be automatically changed in response to a change in the air flow direction as manifested by a rise in the temperature of the heat sink or the heat-generating member. | 05-30-2013 |
20130145612 | HEAT SINK FIN STRUCTURE BLOCKING ELECTROMAGNETIC RADIATION - A system to remove heat from a heat-generating electronic component within a computer chassis and to contain electromagnetic radiation from traversing high-throughput vents in a bezel that forms a portion of the chassis containment structure comprises a heat sink having a fin structure with an inlet face, an outlet face and interconnected air channels therethrough, a base to engage the component and to transfer heat from the component to the fin structure, wherein the inlet face of the fin structure is disposed proximate the vents to block electromagnetic radiation from traversing the vents. In one embodiment, a heat pipe or a spreader bar moves heat from a base engaging a component distal from the bezel to the fin structure having an air inlet face proximal to the vents. | 06-13-2013 |
20130153199 | PERFORMANCE AND NOISE CONTROL FOR A HEAT SINK AIR MOVER - A system and method for cooling a heat-generating device. The system comprises a heat sink base for contacting the heat-generating device, and a plurality of heat sink fins extending from the heat sink base, wherein the fins provide airflow passages that are open along a top, a first side and a second side. An ionic air moving device is disposed along at least one side of the heat sink for moving air through the airflow passages, and a fan is mounted adjacent to the top of the fins for moving air through the airflow passages. A controller selectively controls the airflow through the heat sink using only the ionic device, only the fan, or both the ionic device and the fan. A user or a system component may instruct the controller to enter a performance mode, an energy efficiency mode, or an acoustic mode. | 06-20-2013 |
20130177391 | ELECTROSTATIC CONTROL OF AIR FLOW TO THE INLET OPENING OF AN AXIAL FAN - A method of modifying the airflow to the inlet of an axial fan comprises operating an axial fan to move air longitudinally through an air inlet opening of the axial fan, and, during operation of the axial fan, applying an electrical potential between an emitter and a collector to cause ionic air movement radially outwardly away from a central axis of the axial fan, wherein the radially outward air movement is caused upstream of the axial fan before the air reaches the air inlet opening. | 07-11-2013 |
20140230234 | ELECTROHYDRODYNAMIC AIRFLOW ACROSS A HEAT SINK USING A NON-PLANAR ION EMITTER ARRAY - A method of cooling a heat generating device includes positioning a base of an electronically conductive heat sink in thermal communication with a heat generating device, wherein the heat sink includes a plurality of fins extending in a longitudinal direction from a first end to a second end, and coupling the heat sink to ground. The method further includes emitting ions from a plurality of ion emitter elements disposed in a non-planar pattern along the first ends of the plurality of fins, wherein at least three ion emitter elements are equidistant from the first end of the nearest fin and are positioned in an arc having an axis that extends along the first end of the nearest fin. | 08-21-2014 |