Patent application number | Description | Published |
20100183559 | BIFIDOBACTERIUM LONGUM - The multiple embodiments described herein comprise the genome of a probiotic | 07-22-2010 |
20110151526 | Branched-Chain Fatty Acids And Biological Production Thereof - A method for producing anteiso fatty acid is provided. The method comprises culturing a cell comprising at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes at least one of the following reactions: conversion of pyruvate to citramalate; conversion of citramalate to citraconate; conversion of citraconate to β-methyl-D-malate; conversion of β-methyl-D-malate to 2-oxobutanoate; or conversion of threonine to 2-oxobutanoate, under conditions allowing expression of the polynucleotide(s) and production of anteiso fatty acid. Optionally the cell further comprises at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes conversion of 2-oxobutanoate to 2-aceto-2-hydroxy-butyrate, conversion of 2-aceto-2-hydroxy-butyrate to 2,3-dihydroxy-3-methylvalerate, and/or conversion of 2,3-dihydroxy-3-methylvalerate to α-keto-3-methylvalerate. A cell that produces anteiso fatty acid and a method of using the cell to produce anteiso fatty acid also are provided. | 06-23-2011 |
20110166370 | Scattered Branched-Chain Fatty Acids And Biological Production Thereof - Methods and cells for producing scattered branched-chain fatty acids are provided. For example, the invention provides a method for producing branched-chain fatty acid comprising a methyl on one or more even number carbons. The method comprises culturing a cell comprising an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA and/or an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of succinyl-CoA to methylmalonyl-CoA, under conditions allowing expression of the polynucleotide(s) and production of branched-chain fatty acid. The cell produces more branched-chain fatty acid comprising a methyl on one or more even number carbons than an otherwise similar cell that does not comprise the polynucleotide(s). A cell that produces branched-chain fatty acid and the branched-chain fatty acid also are provided. | 07-07-2011 |
20110171155 | Intermediates And Surfactants useful In Household Cleaning And Personal Care Compositions, And Methods Of Making The Same - Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners). | 07-14-2011 |
20120012130 | Method of Cleansing Hair - Method of cleansing hair comprising: (a) applying a composition to the hair; (b) dissolving and lathering the composition using a water-based solvent; (c) rinsing the hair with a water-based solvent; wherein during the rinsing a total of about 100 gram to about 300 gram of water-based solvent per gram of hair (dry weight) is employed; wherein the composition comprises from about 3 wt % to about 35 wt % of a mixture of at least two compounds of Formula I. | 01-19-2012 |
20120014900 | Personal Care Composition Comprising a Near-Terminal Branched Compound - A personal care composition comprising: a near-terminal branched compound according to Formula I; a cosmetically acceptable aqueous carrier; wherein the near-terminal branched compound is not comprised in a gel network. | 01-19-2012 |
20120014901 | Rinse-Off Conditioning Composition Comprising a Near-Terminal Branched Alcohol - A rinse-off conditioning composition comprising: (a) near-terminal branched alcohol according to Formula I; (b) a cationic surfactant; (c) a terminal aminosilicone; wherein the near-terminal branched alcohol and the cationic surfactant are comprised in a lamellar gel matrix. | 01-19-2012 |
20120258074 | Systems, Models and Methods for Identifying and Evaluating Skin-Active Agents Effective for Treating Dandruff/Seborrheic Dermatitis - Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided. | 10-11-2012 |
20120283112 | Systems and Methods for Identifying Cosmetic Agents for Skin Care Compositions - Provided are methods and systems for determining functional relationships between a cosmetic agent and a skin tissue condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a skin aging tissue condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both. | 11-08-2012 |
20130053300 | Compositions Comprising A Near Terminal-Branched Compound And Methods Of Making The Same - Disclosed herein are novel mixtures of near terminal-branched compounds and derivatives thereof. Further disclosed are methods of making these mixtures, and uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners). | 02-28-2013 |
20130108610 | Inhibition of Microbial Growth by Aconitase Inhibition | 05-02-2013 |
20130109664 | Personal Care Compositions Comprising a Pyrithione and an Iron Chelator | 05-02-2013 |
20130217589 | METHODS FOR IDENTIFYING AGENTS WITH DESIRED BIOLOGICAL ACTIVITY - Provided are methods, systems and apparatus for identifying agents with desired biological activity. Specifically, the methods, systems, and apparatus identify functional relationships between multiple agents and/or between one or more agents and a condition of interest. Data of multiple experimental batches are normalized, batch effects accounted for, and the adjusted data used to create a projection matrix or function. The projection matrix is used to project the data into a projection space, in which the distance between a query agent or a query condition and various candidate agents may be determined. | 08-22-2013 |
20130259816 | Method of Formulating a Skin-Lightening Composition - A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture. | 10-03-2013 |
20130261006 | Method of Generating a Hyperpigmentation Condition Gene Expression Signature - A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium. | 10-03-2013 |
20130261007 | Method of Constructing a Data Structure - A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances. | 10-03-2013 |
20130261024 | System for Identifying Connections Between Perturbagens and Genes Associated with a Skin Hyperpigmentation Condition - A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent. The system also includes a programmable computer with computer-readable instructions that allow the computer to accessing the instances and a hyperpigmentation-relevant gene expression signature stored on the computer readable medium, comparing the hyperpigmentation-relevant gene expression signature to the plurality of the instances, and/or assigning a connectivity score to each of the plurality of instances. | 10-03-2013 |
20130331342 | SYSTEMS AND METHODS FOR IDENTIFYING COSMETIC AGENTS FOR HAIR/SCALP CARE COMPOSITIONS - Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both. | 12-12-2013 |
20140099676 | MICROORGANISMS AND METHODS FOR PRODUCING ACRYLATE AND OTHER PRODUCTS FROM HOMOSERINE - This invention relates to microorganisms that convert a carbon source to acrylate or other desirable products using homoserine and 2-keto-4-hydroxybutyrate as intermediates. The invention provides genetically engineered microorganisms that carry out the conversion, as well as methods for producing acrylate by culturing the microorganisms. Also provided are microorganisms and methods for converting homoserine to 3-hydroxypropionyl-CoA, 3-hydroxypropionate (3HP), poly-3-hydroxypropionate and 1,3-propanediol. | 04-10-2014 |
20140107377 | Microorganisms And Methods For Producing Acrylate And Other Products From Propionyl-CoA - This invention relates to microorganisms that convert a carbon source to acrylate or other desirable products using propionyl-CoA as an intermediate. The invention provides genetically engineered microorganisms that carry out the conversion, as well as methods for producing acrylate by culturing the microorganisms. Also provided are microorganisms and methods for converting propionyl-CoA and propionate to 3-hydroxypropionyl-CoA, 3-hydroxypropionate (3-HP) and poly-3-hydroxypropionate. | 04-17-2014 |
20140296571 | Microorganisms And Methods For Producing Propionic Acid - This invention relates to microorganisms that convert a carbon source to propionate. The invention provides genetically engineered microorganisms that carry out the conversion, as well as methods for producing propionate by culturing the microorganisms. | 10-02-2014 |