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Julia D.
Julia D. Truchsess, Sandy Hook, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20120060669 | NON-CONTACT CYMBAL PICKUP USING MULTIPLE MICROPHONES - As described herein, a sound pickup for musical cymbals includes an integrated assembly attachable to a cymbal stand. The integrated assembly includes a plurality of microphones arranged and electrically connected such that the resulting amplified sound is of optimal quality and of relatively constant loudness regardless of cymbal tilt. In one embodiment, two microphones are used, with the signal phase from one microphone being inverted prior to combination with the signal from the other microphone. The inversion is implemented using an inverter and serves to cancel signals that are in phase with one another and augment signals that are out of phase with one another. This, along with suitable placement of the pickup, exploits the fact that the more desirable components of the cymbal's vibration at the inflection point of the cymbal are out of phase with each other, whereas the less-desirable components are in phase with each other. | 03-15-2012 |
| 20120060670 | ILLUMINATED NON-CONTACT CYMBAL PICKUP - A sound pickup for musical cymbals includes an integrated assembly attachable to a cymbal stand. The integrated assembly includes a plurality of microphones arranged to achieve optimal quality and relatively constant loudness regardless of cymbal tilt. In one embodiment, two microphones are used, with signal phase from one microphone being inverted prior to combination with the signal from the other microphone. An illumination system having one or more light sources and a controller is optional. The controller includes a processor couplable to the pickup by way of a cable having at least one signal conductor for delivering audio signals from the microphone to the processor. The controller also includes an illumination control signal source delivering a DC voltage bias to the pickup for actuating the light sources. | 03-15-2012 |
Julia D. Vrany, Los Altos, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100305697 | System and Method For Treatment of Non-Ventilating Middle Ear by Providing a Gas Pathway Through the Nasopharynx - Methods and devices for providing a gas pathway between the nasopharynx and the Eustachian tube are provided. One device may include a lumen with a valve. A portion of the valve may be tethered to adjacent muscle. Another portion of the valve may be tethered to adjacent cartilage. When the muscle contracts the valve may open through movement of the tethers, and provide a gas pathway between the nasopharynx and the Eustachian tube. | 12-02-2010 |
Julia D. Wulfkuhle, Columbia, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100317740 | Method for Predicting Response to Tamoxifen - This invention relates, e.g., to a method for predicting the response of a subject having, or at risk of developing, breast cancer to Tamoxifen therapy. The method comprises measuring the amount of phosphorylation at residues S70 of Bcl-2, Y992 of EGFR, and/or Y527 of Src in a suitable sample from the subject, wherein a statistically significantly elevated level of phosphorylation at one or more of the three residues compared to a baseline value indicates that the subject is likely to be responsive to Tamoxifen therapy. | 12-16-2010 |
| 20110189173 | PHOSPHORYLATED C-ErbB2 AS A SUPERIOR PREDICTIVE THERANOSTIC MARKER FOR THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue. | 08-04-2011 |
Julia D. Wulfkuhle, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080255243 | Stat3 as a theranostic indicator - This invention relates, e.g., to a method for predicting the response of a subject having estrogen-receptor-positive breast cancer to an inhibitor of the estrogen signaling pathway (e.g. tamoxifen), comprising measuring in a cancer sample from the subject the level of phosphorylation, compared to a baseline value, of one or more of the following members of an interconnected intracellular signaling pathway: (a) 4EBP1, and/or (b) p70S6, and/or (c) STAT3, and/or (d) FAK, wherein a significantly elevated level of phosphorylation of 4EBP1, and/or p70S6 and/or STAT3, and/or a significantly decreased level of phosphorylation of FAK, compared to the baseline value, indicates that the subject is likely to be a non-responder to the inhibitor and/or has a poor prognosis. Additional members of the intracellular signaling pathway whose phosphorylation can be measured are also described. Also described is a method for treating breast cancer in a subject in need thereof, wherein the subject exhibits an elevated level of phosphorylation of these markers, comprising administering to the subject an effective amount of one or more inhibitors of members of the interconnected intracellular signaling pathway. | 10-16-2008 |