Juan P.

Juan P. Eslava, Auburn, MA US

Patent application number	Description	Published
20080275468	SKIN PERMEATION DEVICE FOR ANALYTE SENSING OR TRANSDERMAL DRUG DELIVERY - Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.	11-06-2008

Patent application number	Description	Published
20110197369	CONFORMAL PARTICLE COATINGS ON FIBROUS MATERIALS - Methods are provided for uniform deposition of particles on curved surfaces such as fibers and coatings formed by the particles. Particles in the size range of 10-2000 nm are deposited onto a fibrous material via electrostatic interaction between charge modified fiber material surfaces and oppositely charged particles or metal ions. Various nonmetallic, bimetallic or other charged particles are deposited onto a fibrous material via electrostatic interaction between charged modified fibrous material surfaces and oppositely charged particles. Particles can be directly assembled onto a surface of a fibrous material by controlling hydrogen bonding interactions between interfaces of fibers and functionalized particles. Metal particles can also be deposited by in situ synthesis. A method is also provided for layer-by-layer deposition of particles over a fibrous material.	08-18-2011

Patent application number	Description	Published
20110225660	ORALLY ADMINISTRABLE IMMUNOSTIMULANT PRODUCT FOR AQUACULTURE - An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.	09-15-2011