Patent application number | Description | Published |
20080296492 | METHODS AND APPARATUS FOR PERFORMING CHROMATOGRAPHY AND MASS SPECTROSCOPY WITH SUPERCRITICAL FLUID SAMPLES - Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one wall defining a chamber, sample inlet, an ionization media inlet and an outlet. The sample inlet has a position in communication with a chromatograph receiving a NSC Fluid. The sample inlet receives the NSC Fluid and directs the NSC Fluid into the chamber to form a sample jet of NSC Fluid. The ionization media inlet is placed in fluid communication with a source of ionization media and directs the ionization media into the chamber and the sample jet to create analyte ions. The analyte ions are received in the mass spectrometer vacuum region orifice. | 12-04-2008 |
20090027671 | EVAPORATIVE LIGHT SCATTERING DETECTOR - Embodiments of the present invention are directed to evaporation light scattering detectors having an evaporative chamber having a wall that is in good thermal contact with a heat sink. The heat has a high thermal mass such that a change in temperature of the wall during an analysis is minimized. | 01-29-2009 |
20090122315 | EVAPORATIVE LIGHT SCATTERING DEVICE AND METHODS OF USE THEREOF - Apparatus for the detection of analytes in a fluid, for example the eluant from a liquid chromatography is described. Solvent is evaporated from the eluant to produce a stream of particles when analyte is present in the fluid. The resultant stream of particles is passed through one or more beams of radiation, typically visible light, and radiation scattered by the particles is detected at least at a first angle to a beam of radiation and at a second, different, angle to a radiation beam to produce a signal indicative of the presence of the analyte. | 05-14-2009 |
20090159751 | DEVICES AND METHODS FOR PREVENTING ICE BUILD-UP AND ARTICLES OF MANUFACTURE THAT ARE RESISTANT TO ICE BUILD-UP - Embodiments of the present invention feature heat exchange surfaces having a layer or coating having a lower surface tension than water, to repel water and prevent the formation of condensate on said surface. | 06-25-2009 |
20090218487 | MASS-SPECTROMETER INTERFACE HOUSING - An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed. | 09-03-2009 |
20100133431 | Device, Apparatus And Methods For Mass Spectrometry - The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described. | 06-03-2010 |
20100148057 | Device And Method For Analyzing A Sample - Embodiments of the invention relate to a device for analysing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions. | 06-17-2010 |
20100320374 | DEVICES AND METHODS FOR PERFORMING MASS ANALYSIS - Embodiments of the present invention feature devices and methods for performing mass analysis. One embodiment of the device comprises an inlet housing for mounting on the first wall between the area of low pressure and the area of high pressure. The inlet housing has passages and restrictions which can be adjusted with respect to a sample plume or changed by substituting alternative inlet housings. | 12-23-2010 |
20110107822 | Interfacing With A Digital Microfluidic Device - Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument. | 05-12-2011 |
20110121093 | Apparatus And Methods For Making Analyte Particles - A device for making particulate analyte molecules comprising a nebulizer producing a plume of liquid droplets, a vessel having a chamber to receive the plume in which the chamber has a nebulization section, a desolvation section. The nebulization section is cooled to form a condensed waste from a portion of said plume. The desolvation section is heated to form solvent gas molecules and particulate analyte molecules. | 05-26-2011 |
20110134428 | Evaporative Light Scattering Detector - Described is a detector for receiving the eluent from a liquid- or supercritical-fluid chromatograph in which a signal indicative of the presence of an analyte in the eluent is generated by the scattering of light by desolvated particles of the analyte. The detector includes a nebulizer for generating an aerosol from the eluent in a chamber that has a wall in thermal communication with a heat sink. Changes in the temperature of the wall during an analysis of the eluent are reduced by the transfer of heat to the first heat sink. | 06-09-2011 |
20110266433 | Apparatus And Methods For Gas Chromatography - Mass Spectrometry - The invention provides improved apparatus for, and methods of, ionizing analyte molecules in a flow of gas, typically at or around atmospheric pressure. The invention may be used to facilitate mass spectrometric analysis of analytes comprised in the effluent form a gas chromatograph. Ionization may be effected by atmospheric pressure chemical ionization or by atmospheric pressure photo ionization. | 11-03-2011 |
20110266434 | Stacked-Electrode Peptide-Fragmentation Device - A chemical processing apparatus includes a fragmentation device that includes a linear set of stacked electrodes and a voltage control module that forms DC potential wells of opposite polarity for mutual confinement of opposite polarity ions. A method of protein analysis includes confining positive peptide ions and negatively charged reagent anions in, respectively, first and second DC potential wells in a fragmentation device, mixing the ions, in the fragmentation device, and analyzing ion fragments formed in the mixture. | 11-03-2011 |
20110271755 | Apparatus And Methods For The Measurement Of Mass Related Parameters - Embodiments of the present invention are directed to resonating detection devices in which the sample flows through a conduit having a section in which the conduit is grouped or concentrated with the point of maximum movement. | 11-10-2011 |
20110290994 | Methods And Apparatus For Performing Gas And Liquid Mass Spectrometry - Embodiments of the present invention feature devices and methods for performing gas chromatography and liquid chromatography with mass spectrometry. The device and method feature a removable housing which housing contains the gas samples when the mass spectrometry receives gas samples. The device fits an atmospheric pressure ionization housing and upon removal, the atmospheric pressure ionization housing receives liquid samples. | 12-01-2011 |
20120160690 | Capillary Column Cartridge - Described is a capillary column cartridge. The cartridge can be used to perform separations according to various techniques such as capillary gas chromatography, capillary electrophoresis and capillary liquid chromatography. The cartridge includes a capillary column secured in a cartridge body. The capillary column includes an inlet port and an outlet port that, in some embodiments, are disposed on a planar surface of the body. When the body is engaged to a separation system module, the inlet port is aligned to receive a sample to be separated and the outlet port is aligned to provide the separated sample to the separation system module. The path of the capillary through the body has a non-planar path shape such as a coil shape. Consequently, longer column lengths can be accommodated, leading to an improvement in separation resolution. The body can include a material having a high thermal conductivity to achieve improved thermal performance. | 06-28-2012 |
20120168311 | Systems And Methods For Coupling Molecule Separation Devices To Analytical Instruments - Described is a capillary that interfaces with an analysis system. The capillary comprises a non-conductive tubing and a conductive region proximate to an output end of the non-conductive tubing. The conductive region comprises a plurality of porous regions and non-porous regions positioned about a circumference of the non-conductive tubing. The porous regions separated from each other by the non-porous regions. Advantageously, the arrangement of porous regions provides mechanical stability about the conductive region. | 07-05-2012 |
20120286151 | Devices and Methods for Analyzing Surfaces - Embodiments of the present invention are directed to devices and methods for performing an analysis of a sample having a sample surface. The device and method feature a frame element affixed to a sample holder, jet element and a charged particle analyzer having an ion receiving orifice. The jet element directs a jet of gas towards the sample surface held by said sample holder focused on less than 2.0 mm | 11-15-2012 |
20130020483 | APPARATUS FOR PHOTOIONIZATION OF AN ANALYTE IN AN ELUENT OF A CHROMATOGRAPHY COLUMN - Described is an apparatus for photoionization of an analyte in an eluent of a chromatography column. The apparatus includes a laser to generate a beam of optical radiation, a mass spectrometer and one or more optical components to receive the beam and to generate a concentrated region of optical radiation near an orifice of the mass spectrometer so that an analyte in the vapor phase of the eluent is ionized. Alternatively, the apparatus includes a laser driven light source, a mass spectrometer and an optical imaging system. The laser driven light source includes an optical enclosure having an ionizable medium, an ignition source and a laser for pumping optical radiation into the ionizable medium. The optical imaging system generates an image of the pumped region of the ionized medium proximate to the orifice of the mass spectrometer to thereby photoionize an analyte in the vapor phase of the eluent. | 01-24-2013 |
20130134079 | MOBILE PHASE SOLVENT DELIVERY MODULE - Described is a mobile phase solvent delivery module for liquid chromatography and supercritical fluid chromatography systems. The module includes a pump disposed in a fluid path that conducts a mobile phase solvent. The pump provides the mobile phase solvent at an increased pressure. The module also includes a purification cartridge disposed in the fluid path either before or after the pump. The purification cartridge has an inlet to receive the mobile phase solvent and an outlet to provide a purified mobile phase solvent, and includes a packing material for removing an impurity from the mobile phase solvent. In various embodiments, the module also includes one or more additional components to allow various techniques for regeneration or replacement of spent purification cartridges. For example, the module may also include one or more of a temperature control module, a fluidic switch and one or more additional purification cartridges. | 05-30-2013 |
20130269424 | Chromatographic Optical Detection System - A chromatographic optical detection system includes an optical detector disposed to receive light scattered from a stream of particles and configured to convert the received light to an electrical signal; a signal-processing unit in signal communication with the optical detector to receive the electrical signal, and configured to convert the electrical signal to digital pulses and count the digital pulses to output a first signal corresponding to a number of particles detected in a time interval, and configured to integrate and digitize the electrical signal to output a second signal corresponding to the number of particles detected in the time interval; and a data station in signal communication with the signal-processing unit, and configured to select the first signal, if the number of particles detected in the time interval is less than a threshold criterion, and to select the second signal if the number of particles detected in the time interval exceeds the threshold criterion. The threshold criterion is associated with a saturation condition. | 10-17-2013 |
20130333467 | Measuring Fluid Density - An apparatus includes a vibration element defining a fluidic passageway; an excitation element for exciting vibration of the vibration element; a detector for providing a signal representative of the frequency excited; and control electronics configured to determine a density of a fluid flowing through the fluidic passageway based, at least in part, on the signal provided by the detector. The vibration element is configured such that Coriolis force induced twisting of the vibration element is substantially inhibited. | 12-19-2013 |
20150021265 | FLOW SPLITTING IN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS - A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow. | 01-22-2015 |
20150048255 | Ion Source for Mass Spectrometer and Method of Producing Analyte Ion Stream - An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream. Preferably, the droplets have a diameter that is greater than a preset value to increase the kinetic energy of the droplets. Additionally, the droplet generator can be configured to create a gas flow that increases the kinetic energy of the droplets. In one embodiment, the target is positioned upstream of an inlet of a mass spectrometer so that the ion stream enters the inlet. In another preferred embodiment, the target is positioned downstream of the inlet so that the stream of droplets passes through the inlet of the mass spectrometer, and the inlet is provided with a pressure drop that increases the kinetic energy of the droplets. | 02-19-2015 |