| Patent application number | Description | Published |
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| 20080204762 | Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets - Methods, systems, and computer program products for removing undesired artifacts in Fourier domain optical coherence tomography (FDOCT) systems using integrating buckets are disclosed. According to one aspect, a method includes introducing a variable phase delay between a reference arm and a sample arm of an FDOCT interferometer using sinusoidal phase modulation. Further, the method includes acquiring an interferometric intensity signal using an integrating buckets technique. The method also includes resolving the interferometric intensity signal to remove undesired artifacts. | 08-28-2008 |
| 20090141237 | Integrated Optical Coherence Imaging Systems for Use in Ophthalmic Applications and Related Methods and Computer Program Products - A system for imaging a sample is provided that includes an optical coherence tomography (OCT) portion having an associated OCT path. A second imaging portion is provided having an associated second image path, different from the OCT path. A fixation target having an associated fixation path, different from the second image path and the OCT path is also provided. The OCT path, the second image path and the fixation path are confocal at a common image plane. Related handheld systems are also provided. | 06-04-2009 |
| 20090237673 | Spectral Domain Phase Microscopy (SDPM) Dual Mode Imaging Systems and Related Methods and Computer Program Products - Some embodiments of the present invention provide optical coherence tomography systems including an OCT engine and a processor. The OCT engine is configured to provide both standard OCT imaging and spectral domain phase microscopy (SDPM) imaging. The processor is coupled to the OCT engine and is configured to use a first signal processing method when the OCT engine is configured to provide standard OCT imaging and a second signal processing method when the OCT engine is configured to provide SDPM imaging. Related methods and computer program products are also provided. | 09-24-2009 |
| 20090268020 | Optical Coherence Tomography (OCT) Imaging Systems for Use in Pediatric Ophthalmic Applications and Related Methods and Computer Program Products - Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided. | 10-29-2009 |
| 20090268161 | OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING SYSTEMS HAVING ADAPTABLE LENS SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS - OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject. | 10-29-2009 |
| 20090270738 | Methods for single-pass volumetric bidirectional blood flow imaging Spectral Domain Optical Coherence Tomography using a modified hilbert transform - The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting reconstructed image maps the components of moving scatterers flowing into and out of the imaging axis onto opposite image halfplanes, enabling volumetric bidirectional flow mapping without manual segmentation. | 10-29-2009 |
| 20090316160 | OPTICAL COHERENCE IMAGING SYSTEMS HAVING A REDUCED EFFECTIVE LINEWIDTH AND METHODS OF USING THE SAME - Frequency domain optical coherence imaging systems have an optical source, an optical detector and an optical transmission path between the optical source and the optical detector. The optical transmission path between the optical source and the optical detector reduces an effective linewidth of the imaging system. The optical source may be a broadband source and the optical transmission path may include a periodic optical filter. | 12-24-2009 |
| 20100201991 | Methods, Systems and Computer Program Products for Characterizing Structures Based on Interferometric Phase Data - Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position. | 08-12-2010 |
| 20100225925 | Methods, Systems and Computer Program Products for Optical Coherence Tomography (OCT) Using Automatic Dispersion Compensation - Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated. The acquired raw spectral data and the postulated trial spectral phase data are assembled into trial complex spectrum data. Trial A-scan data is computed by performing an inverse Fourier transform on the trial complex spectrum data and determining the magnitude of a result. | 09-09-2010 |
| 20100231917 | Methods and Systems for Removing Undesired Artifacts in Fourier Domain Optical Coherence Tomography (FDOCT) Systems Using Continuous Phase Modulation and Related Phase Modulators - Methods, fourier domain optical coherence tomography (FDOCT) interferometers and computer program products are provided for removing undesired artifacts in FDOCT systems using continuous phase modulation. A variable phase delay is introduced between a reference arm and a sample arm of an FDOCT interferometer using continuous phase modulation. Two or more spectral interferograms having different phase delay integration times are generated. The spectral interferograms are combined using signal processing to remove the undesired artifacts. Systems and methods for switching between stepped and continuous phase shifting Fourier domain optical coherence tomography (FDOCT) and polarization-sensitive optical coherence tomography (PSOCT) are also provided herein. | 09-16-2010 |
| 20100265511 | SYSTEM FOR FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY - Optical coherence tomography (OCT) is an imaging method which can image with micrometer-scale resolution up to a few millimeters deep into, for example, living biological tissues and preserved tissue samples. An improved apparatus and image reconstruction algorithm for parallel Fourier Domain OCT which greatly eases requirements for interferometer stability and also allows for more efficient parallel image acquisition is provided. The apparatuses and algorithms reconstruct images from interfered, low-coherence, multiwave length signals having a .pi. radian phase difference relative to one another. Other numbers of signals and other phase differences may be alternatively used, with some combinations resulting in higher resolution and image stability. The apparatus also eliminates a need for bulk optics to modulate a phase delay in a reference arm of the optical path. Images may be reconstructed using two spectrometers, where each is coupled to a detector array such as a photodiode array. | 10-21-2010 |
| 20100315592 | Optical Coherence Imaging Systems Having a Mechanism for Shifting Focus and Scanning Modality - Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein. | 12-16-2010 |
| 20100321636 | Optical Coherence Imaging Systems Having a Mechanism for Shifting Focus and Scanning Modality and Related Adapters - Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein. | 12-23-2010 |
| 20110001928 | Systems for Imaging Structures of a Subject and Related Methods - Systems for imaging structures of a subject are provided. The subject has an optical axis, a pupil, and a nodal point. The system includes an image capture device; a first structure including a mount for the subject to be imaged by the image capture device, the first structure providing at least two rotational degrees of freedom; a second structure including a mount for the image capture device, the second structure providing at least two translational degrees of freedom; and a means for aligning the image capture device in relation to the optical axis, the pupil, and the nodal point of the subject. | 01-06-2011 |
| 20110032533 | Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography - Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed. | 02-10-2011 |
| 20110075946 | Methods, Systems and Computer Program Products for Analyzing Three Dimensional Data Sets Obtained from a Sample - Methods of analyzing three dimensional data sets obtained from a sample over time are provided. The methods include aligning first and second volume intensity projection (VIP) images based on at least one landmark in the first and second VIP images. The first and second VIP images are obtained from a first three dimensional data set obtained from the sample at a first time and a second three dimensional data set obtained from the sample at a second time, respectively. | 03-31-2011 |
| 20110096291 | Systems for Extended Depth Fourier Domain Optical Coherence Tomography (FDOCT) and Related Methods - Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein. | 04-28-2011 |
| 20110102802 | Systems for Comprehensive Fourier Domain Optical Coherence Tomography (FDOCT) and Related Methods - Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second. | 05-05-2011 |
| 20110109914 | METHOD AND APPARATUS FOR POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY - A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation) 2.2° over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°. | 05-12-2011 |
