Patent application number | Description | Published |
20100036488 | Therapeutic device for pain management and vision - A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane. | 02-11-2010 |
20110208300 | Corneal Onlay Devices and Methods - A corneal only is configured to adhere to the cornea so as to inhibit epithelial growth under the onlay. Structures can be provided on the onlay to adhere the onlay to the eye. At least one of an epithelial layer or the water inhibiting layer can be provided on or over the onlay, for example a natural epithelial layer or water inhibiting layer that inhibits, for example minimizes, water penetration into the onlay, so as to adhere the onlay to the eye with pumping of the endothelium. The water inhibiting layer may comprise a therapeutic covering positioned over the onlay to inhibit swelling of the cornea. The posterior surface of the onlay may be shaped so as to fit the anterior exposed surface of the cornea. | 08-25-2011 |
20120136322 | Anterior Segment Drug Delivery - A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye. | 05-31-2012 |
20130066283 | Corneal Denervation for Treatment of Ocular Pain - Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment. | 03-14-2013 |
20130278890 | CONTACT LENSES FOR DIFFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 10-24-2013 |
20130293832 | CONTACT LENSES FOR REFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 11-07-2013 |
20150055081 | BIMODULAR CONTACT LENSES - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion configured to be disposed over the optical region of the cornea and having a central portion disposed between an anterior portion and a posterior portion. The inner optic portion is configured to at least partially diverge from the shape of the cornea to provide at least one lenticular volume between a posterior surface of the inner optic portion and the cornea. The central portion may be characterized by a thickness from 50 μm to 900 μm and a modulus form 20 MPa to 1500 MPa. | 02-26-2015 |
20150077701 | CONTACT LENSES FOR REFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 03-19-2015 |
Patent application number | Description | Published |
20090081338 | CITRUS JUICE APPARATUS WITH UNDESIRED MATERIAL RELEASE DETECTOR AND RELATED METHODS - A citrus juice apparatus may include at least one citrus juice processing device. The at least one juice processing device may include at least one juice output having a flow of juice therethrough. The at least one juice processing device upon a malfunction may cause an undesired material release along with the flow of juice into the at least one juice output. An undesired material release detector may be coupled to the at least one juice output for detecting the undesired material release. The detector may operate based upon magnetic proximity sensing of a moving filter plate within a housing of the detector. Alternatively, the detector may operate using a filter plate, and based upon pressure. | 03-26-2009 |
20120021098 | APPARATUS AND METHOD FOR SENSING AND CONTROLLING THE CONCENTRATION OF PULP IN A CONCENTRATED PULP STREAM - A juice processing apparatus includes a concentrator for generating at least one concentrated pulp stream, and a pulp pasteurizer coupled downstream from the concentrator. A flow restrictor is coupled in the at least one concentrated pulp stream for generating a pressure drop therein. The pressure drop is indicative of a concentration of pulp in the at least one concentrated pulp stream. At least one pressure sensor is associated with the flow restrictor for sensing the pressure drop. A controller is for controlling the concentrator based upon the sensed pressure drop. | 01-26-2012 |
20120021102 | APPARATUS AND METHOD FOR SENSING THE CONCENTRATION OF PULP IN A CONCENTRATED PULP STREAM - A juice processing system includes at least one fluid line for a concentrated pulp stream, and a flow restrictor coupled in fluid communication with the at least one fluid line for generating a pressure drop in the concentrated pulp stream indicative of a concentration of pulp therein. The system may further include at least one pressure sensor associated with the flow restrictor for sensing the pressure drop, and a controller coupled to the at least one pressure sensor for generating at least one control signal based upon the sensed pressure drop. The control signal may be for an upstream and/or a downstream control device. | 01-26-2012 |
20120282378 | CITRUS JUICE APPARATUS WITH UNDESIRED MATERIAL RELEASE DETECTOR AND RELATED METHODS - A citrus juice apparatus may include at least one citrus juice processing device. The at least one juice processing device may include at least one juice output having a flow of juice therethrough. The at least one juice processing device upon a malfunction may cause an undesired material release along with the flow of juice into the at least one juice output. An undesired material release detector may be coupled to the at least one juice output for detecting the undesired material release. The detector may operate based upon magnetic proximity sensing of a moving filter plate within a housing of the detector. Alternatively, the detector may operate using a filter plate, and based upon pressure. | 11-08-2012 |
20140030393 | BLOCKED ORIFICE TUBE SENSOR FOR CITRUS JUICE EXTRACTOR AND RELATED METHODS - A juice extractor includes a strainer tube mounted to receive juice and pulp of a fruit. An orifice tube reciprocates within the strainer tube and has an ejection port and is configured to generate pressure and separate juice and pulp, collect core, and discharge core out of the ejection port. A sensor is positioned adjacent the orifice tube and configured to sense material ejected from the ejection port. | 01-30-2014 |
20140342061 | FRUIT OR VEGETABLE PULP PROCESSING APPARATUS WITH DEFECT SEPARATOR AND ASSOCIATED METHODS - A fruit or vegetable pulp processor includes a defect separator configured to separate defects from a fruit or vegetable pulp stream. The defect separator may have associated therewith at least one adjustable control parameter relating to an amount of defect separation from the fruit or vegetable pulp stream. At least one image sensor may be configured to sense defects in the fruit or vegetable pulp stream, and a controller may be configured to adjust the at least one adjustable control parameter of the defect separator based upon sensed defects. Accordingly, the amount or level of defects in the fruit or vegetable pulp stream may be controlled to provide a desired balance between yield and quality. | 11-20-2014 |
Patent application number | Description | Published |
20080241135 | Methods for reducing viral load in HIV-1-infected patients - This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5 | 10-02-2008 |
20100178290 | Methods for reducing viral load in HIV-1 infected patients - This invention provides a method of reducing viral load in an HIV-1-infected human subject which comprises administering to the subject an effective HIV-1 viral load reducing dose of a CCR5 receptor antagonist, such as a humanized antibody designated PRO 140 or an anti-CCR5 receptor monoclonal antibody, wherein the viral load reducing dose achieves an average maximum decrease of viral load in the subject of at least 1.83 log | 07-15-2010 |
20110200592 | Methods For Reducing Viral Load in HIV-1 Infected Patients - This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5 | 08-18-2011 |
20130216526 | METHODS FOR REDUCING VIRAL LOAD IN HIV-1 INFECTED PATIENTS - This invention provides a method of reducing viral load in an HIV-1-infected human subject which comprises administering to the subject an effective HIV-1 viral load reducing dose of a CCR5 receptor antagonist, such as a humanized antibody designated PRO 140 or an anti-CCR5 receptor monoclonal antibody, wherein the viral load reducing dose achieves an average maximum decrease of viral load in the subject of at least 1.83 log | 08-22-2013 |
20140377259 | METHODS FOR INHIBITING HIV-1 REPLICATION INVOLVING THE ADMINISTRATION OF AN ANTI-CCR5 RECEPTOR MONOCLONAL ANTIBODY AND SMALL MOLECULE CCR5 RECEPTOR ANTAGONIST - This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5 | 12-25-2014 |
Patent application number | Description | Published |
20080243613 | Optimization of pay per click advertisements - An advertising management service allows an advertiser to create an advertisement and associate keywords with the advertisement. The advertising management service submits the advertisement to multiple search engine advertising networks on behalf of the advertiser. Periodically, the advertising management service receives a performance indicator for the keywords from the search engine advertising networks. Using the performance indicator, the advertising management service identifies some of the keywords as low performing keywords. The advertising management service replaces the low performing keywords with new keywords on the multiple search engine advertising networks. The advertising management service may also periodically reallocate a budget for the advertisement among the multiple search engine advertising networks based on the performance indicator. | 10-02-2008 |
20080249989 | Integrating a hosted services system and a search system - Technologies are described herein for integrating a hosted services system and a search system. A query for an entity is received at a search system. If an entry for the entity indicates that an information site does not exist for the entity, a request to create an information site for the entity is transmitted to a hosted services system. When the hosted services system receives the request, the hosted services system utilizes provided information to create a basic information site for the entity. Once the information site has been created, a network address for the information site is returned to the search system. The search system modifies an existing entry or creates a new entry for the entity that includes the provided network address. Modifications to information regarding the entity made at the hosted services system are passed to the search system for use in updating the entry. | 10-09-2008 |
20140172584 | OPEN ADVERTISEMENT DISTRIBUTION NETWORK - Methods, computer systems, and computer-storage media are provided for creating an open advertisement distribution network. A Web server hosting a Web site is accessed. The Web server has an advertisement definition file located at a predefined URL, and the advertisement definition file includes at least one advertisement file. The advertisement file is extracted and communicated to one or more advertisement publishers. | 06-19-2014 |
20140372201 | PROMOTIONAL FORMS FOR ADVERTISING - One or more techniques and/or systems are provided for generating a promotional form and/or for maintaining a promotional activity catalog. For example, a promotional activity catalog comprising one or more promotional activities may be exposed to an advertiser entity (e.g., a restaurant business). A set of promotional activities selected from the promotional activity catalog may be identified (e.g., a coupon activity, a reserve table activity, a view slideshow activity, etc.). A promotional form, such as an interactive user interface, comprising promotional activity interfaces for the set of promotional activities may be generated. Monetization schemes may be associated with such promotional activity interfaces. In this way, the promotional form may comprise various promotional activities and/or monetization schemes. The promotional form may be presented to users to promote the advertiser entity (e.g., a user may reserve a table at the restaurant business through a reservation promotional activity interface within the promotional form). | 12-18-2014 |