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João Manuel
João Manuel Braz Goncalves, Montijo PT
| Patent application number | Description | Published |
|---|---|---|
| 20100136627 | Engineered Rabbit Antibody Variable Domains and Uses Thereof - The present invention relates to methods for screening and producing polypeptides that immunospecifically bind to an antigen, which: polypeptides comprise binding domains that are derived from rabbit immunoglobulin. Using rabbit antibody heavy-chain or light-chain scaffolds, the methods of the invention allow identification of novel CDR loops and framework regions that confer enhanced stability and/or affinity to isolated immunoglobulin variable domains, in particular, relative to those derived from rodent antibodies. The enhanced stability and/or affinity of the variable domains of the invention permit their use in the production research tools or therapeutic immunospecific polypeptides, including single domain immunospecific polypeptides, i.e., comprising one of a V | 06-03-2010 |
João Manuel Braz Goncalves, Montijo PT
| Patent application number | Description | Published |
|---|---|---|
| 20100136627 | Engineered Rabbit Antibody Variable Domains and Uses Thereof - The present invention relates to methods for screening and producing polypeptides that immunospecifically bind to an antigen, which: polypeptides comprise binding domains that are derived from rabbit immunoglobulin. Using rabbit antibody heavy-chain or light-chain scaffolds, the methods of the invention allow identification of novel CDR loops and framework regions that confer enhanced stability and/or affinity to isolated immunoglobulin variable domains, in particular, relative to those derived from rodent antibodies. The enhanced stability and/or affinity of the variable domains of the invention permit their use in the production research tools or therapeutic immunospecific polypeptides, including single domain immunospecific polypeptides, i.e., comprising one of a V | 06-03-2010 |
João Manuel Calado Da Silva, Aljustrel PT
| Patent application number | Description | Published |
|---|---|---|
| 20110129670 | NANOMETRIC-SIZED CERAMIC MATERIALS, PROCESS FOR THEIR SYNTHESIS AND USES THEREOF - The disclosed subject concerns nanometric-sized ceramic materials in the form of multiple crystalline structures, composites, or solid solutions, the process for their synthesis, and uses thereof. These materials are mainly obtained by detonation of two water-in-oil (W/O) emulsions, one of which is prepared with precursors in order to present a detonation regime with temperature lower than 2000° C., and they present a high chemical and crystalline phase homogeneity, individually for each particle, as well as a set of complementary properties adjustable according to the final applications, such as a homogeneous distribution of the primary particles, very high chemical purity level, crystallite size below 50 nm, surface areas by mass unit between 25 and 500 m2/g, and true particle densities higher than 98% of the theoretical density. This set of characteristics makes this materials particularly suitable for a vast range of applications in the nanotechnology field, such as, for example, nanocoatings, magnetic nanofluids, nanocatalysts, nanosensors, nanopigments, nanoadditives, ultra light nanocomposites, drug release nanoparticles, nanomarkers, nanometric films, etc. | 06-02-2011 |
João Manuel Pinto Filipe, Almere NL
| Patent application number | Description | Published |
|---|---|---|
| 20100198861 | METHOD AND SYSTEM FOR PROCESSING MEASURMENT DATA FOR WEBSITE STATISTICS - A method and a system for processing measurement data for website statistics are provided. The measurement data is processed in parallel bucket writers and stored in buckets. Upon receiving a report request the buckets are processed in parallel bucket queriers to obtain report data. | 08-05-2010 |
João Manuel Pinto Filipe, Almere NL
| Patent application number | Description | Published |
|---|---|---|
| 20100198861 | METHOD AND SYSTEM FOR PROCESSING MEASURMENT DATA FOR WEBSITE STATISTICS - A method and a system for processing measurement data for website statistics are provided. The measurement data is processed in parallel bucket writers and stored in buckets. Upon receiving a report request the buckets are processed in parallel bucket queriers to obtain report data. | 08-05-2010 |
João Manuel Ribeiro Da Silva Tavares, Porto PT
| Patent application number | Description | Published |
|---|---|---|
| 20110152621 | DEVICE FOR MEASURING AND ANALYSING THE COLOUR OF THE OUTER EAR AND EAR CANAL - The present application concerns a device for measurement and analysis of the middle ear and ear channel colour for the diagnosis of ear infections. The device is composed of a otoscope ( | 06-23-2011 |