Johnston, PA
Allen David Johnston, Westchester, PA US
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20080241083 | Artificial nail compositions and related methods - The invention comprises a polymerizable monomer composition for application to the nail surface and polymerization thereon to yield an artificial nail structure, comprising at least one multicarbonyl-vinyl containing monomer; a polymerized artificial nail structure having a thickness of about 10-60 mils, and a modulus of elasticity of about 550-800 N/m | 10-02-2008 |
Brian Keith Johnston, Schnecksville, PA US
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20090025422 | Controlling Liquefaction of Natural Gas - A gas liquefaction process, especially for producing LNG, maintains product flow rate and temperature by controlling the refrigeration so that variation to reduce any difference between actual and required product temperatures is initiated before variation of the product flow rate to reduce any difference between actual and required flow rates. | 01-29-2009 |
20120079850 | Controlling Liquefaction of Natrual Gas - A gas liquefaction process, especially for producing LNG, maintains product flow rate and temperature by controlling the refrigeration so that variation to reduce any difference between actual and required product temperatures is initiated before variation of the product flow rate to reduce any difference between actual and required flow rates. | 04-05-2012 |
20160102908 | Refrigerant Recovery in Natural Gas Liquefaction Processes - Described herein is a method of removing refrigerant from a natural gas liquefaction system in which vaporized mixed refrigerant is withdrawn from the closed-loop refrigeration circuit and introduced into a distillation column so as to be separated into an overhead vapor enriched in methane and a bottoms liquid enriched in heavier components. Overhead vapor is withdrawn from the distillation column to form a methane enriched stream that is removed from the liquefaction system, and bottoms liquid is reintroduced from the distillation column into the closed-loop refrigeration circuit. Also described are methods of altering the rate of production in a natural gas liquefaction system in which refrigerant is removed as described above, and a natural gas liquefaction systems in which such methods can be carried out. | 04-14-2016 |
Daniel S. Johnston, Trappe, PA US
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20130116658 | APPARATUS FOR REMOVING CHEMOTHERAPY COMPOUNDS FROM BLOOD - A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject. | 05-09-2013 |
Daniel Stephen Johnston, Collegeville, PA US
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20130189274 | PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY BIOMARKERS - Methods for treating breast cancer, specifically cancers resistant to treatment with one or more known breast cancer treatment drugs, and related patient selection strategies for predicting patient response to drug therapy, such strategies including detecting the presence or absence in a patient of one or more of PIK3CA gene amplification, a mutation in PIK3CA, and a decrease in PTEN protein expression, and treating a patient positive for the presence of one or more of same by administering to the subject a pan-ErbB tyrosine kinase inhibitor. | 07-25-2013 |
Daniel Steven Johnston, Trappe, PA US
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20120010240 | CUT-POINT IN PTEN PROTEIN EXPRESSION THAT ACCURATELY IDENTIFIES TUMORS AND IS PREDICTIVE OF DRUG RESPONSE TO A PAN-ErbB INHIBITOR - A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value. | 01-12-2012 |
Danvers E. Johnston, Berwyn, PA US
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20100144535 | PARALLEL FABRICATION OF NANOGAPS AND DEVICES THEREOF - Disclosed are devices comprising multiple nanogaps having a separation of less than about 5 nm. Also disclosed are methods for fabricating these devices. | 06-10-2010 |
Danvers E. Johnston, Philadelphia, PA US
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20100247381 | PROCESSES AND APPLICATIONS OF CARBON NANOTUBE DISPERSIONS - Disclosed are copolymers of carbon nanotubes, as well as processes and applications of carbon nanotube dispersions. Carbon nanotube emulsions and related technology are also disclosed. The controlled deposition of carbon nanotubes on substrates is also provided. Methods of purifying single-walled carbon nanotubes are also provided. Devices made according to the disclosed methods are further described herein. | 09-30-2010 |
David Johnston, Wyndmoor, PA US
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20140017376 | Bio-based Fiber Gums (BFGs) and Processes for Producing BFGs - Processes for the preparation of bio-based fiber gums and products produced by these processes and some of their uses. | 01-16-2014 |
20140134684 | Methods For Obtaining Oil From Maize Using Acid Protease and Cell-wall Polysaccharide-degrading Enzymes - Disclosed are methods for obtaining oil from maize, involving grinding maize kernels to form flour, adding water to the flour to form a slurry, and incubating the slurry with α-amylase for about 10 minutes to about 180 minutes at a temperature of about 75° to about 120° C. and at a pH of about 3 to about 7 to form a mash, cooling the mash to about 15° C. to about 40° C. and adding a nitrogen source, glucoamylase, yeast, acid protease, and cell-wall polysaccharide-degrading enzymes to form a beer containing ethanol and oil, wherein the beer has a pH of about 3 to about 7, and recovering oil from the beer. | 05-15-2014 |
20150366244 | Insoluble Biomass Gel (IBG) And Methods Of Preparing - Processes for the preparation of an insoluble biomass gel involving: | 12-24-2015 |
20150368372 | Cellulosic Arabinoxylan fiber (CAF) And Methods Of Preparing - Processes for the preparation of cellulosic arabinoxylan fiber. Cellulosic arabinoxylan fiber prepared by the processes. Edible formulations, containing the cellulosic arabinoxylan fiber, wherein the cellulosic arabinoxylan fiber functions as bulking agents in the edible formulation. Methods of stabilizing an emulsion, involving mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber with an emulsion to stabilize said emulsion. Methods of increasing the water holding capacity of a composition, involving mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition. Method of increasing the bulk of a composition, involving mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition. Methods of increasing the viscosity of a composition, involving mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the viscosity of said composition. | 12-24-2015 |
David B. Johnston, Wyndmoor, PA US
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20140273134 | Barley-Based Biorefinery Process - The barley-based biorefinery process comprises a method of optimizing the production of ethanol and value-added products from barley feedstock. Specifically, the biorefinery process is an integrated barley treatment process that utilizes essentially all components of barley (including the barley hulls) to efficiently produce ethanol and other value-added liquids and solids. | 09-18-2014 |
David Charles Johnston, Greensburg, PA US
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20110164934 | ROUND CUTTING INSERT WITH ASYMMETRIC CHIPBREAKER FEATURE - A round cutting insert includes a top surface, a clearance side surface and a bottom surface. The top surface includes an asymmetric chipbreaker feature adjacent a cutting edge that includes a finishing portion, a roughing portion, and a transition portion. The asymmetric chipbreaker feature includes a first rake face extending from the cutting edge, a second rake face between a bottom face and the first rake face, and a back face between a central island and the bottom face. The second rake face and the back face are sinusoidal waveforms with different periods to cause the distances from the cutting edge to the second rake face and back face to vary. The first and second rake faces are formed at different rake angles to provide effective chip control during machining operations. | 07-07-2011 |
Duke Johnston, Landenberg, PA US
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20130269616 | Method and Device for Attracting and Collecting Earthworms - An earthworm collecting device that is highly effective in causing earthworms to surface from their holes during the day time or at night and come to the surface. The device generates a rasping noise and a series of vibrations that resonate through the ground. These resonating vibrations cause the earthworms to surface which then allows for easy and rapid collection. | 10-17-2013 |
Eugene E. Johnston, Pittsburgh, PA US
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20140101230 | METHOD AND SYSTEM FOR IMPLEMENTING NOTIFICATIONS - A method for implementing notifications. The method includes storing data defining notification operations in a memory. The data defining notification operations include a hierarchy of Uniform Resource Identifiers (URIs) and Extensible Markup Language (XML) document schema defining XML documents. The method further includes receiving a notification command including an URI and a Hypertext Transfer Protocol (HTTP) method; determining a notification operation based on the data defining notification operations stored in the memory and the notification command received; and executing the notification operation based on the notification command. | 04-10-2014 |
20140101290 | SYSTEM AND METHOD FOR INVOKING APPLICATION COMMANDS WITH WEB SERVICE CALLS - A method for invoking an application command includes generating a web service request. The web service request includes an extensible markup language (XML) document in the body of the web service request. The XML document includes information indicating an application command. The method further includes transmitting the web service request to a server using a network communication protocol. | 04-10-2014 |
20140101291 | SYSTEM AND METHOD FOR INVOKING WEB SERVICES FROM COMMAND-LINE PROGRAM - A method for invoking web services includes invoking a command-line program. The program receives a plurality of parameters. The method further includes generating a web service request based on the plurality of parameters. The web service request comprises an extensible markup language (XML) document, and the XML document comprises information indicating an application command. The method also includes transmitting the web service request to a server using a network communication protocol. | 04-10-2014 |
20140101532 | METHOD AND SYSTEM FOR IMPLEMENTING COMMANDS - A method for implementing commands includes storing data defining command operations in a memory. The data defining command operations include a hierarchy of Uniform Resource identifiers (URIs) and Extensible Markup Language (XML) document schema defining XML documents. The method also includes receiving a command request from a remote computer. The command request contains an URI and a Hypertext Transfer Protocol (HTTP) method. Further, the method includes determining a command operation based on the data defining command operations stored in the memory and the command request received, and executing the command operation based on the command request. | 04-10-2014 |
Gary Allan Johnston, Mcconnellsburg, PA US
Gerald W. Johnston, Beech Creek, PA US
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20110011185 | Flowmeter and manifold therefor - An acoustic displacement flowmeter for determining flow rate of a fluid has a fluid flow line defining a flow path for the fluid. The fluid flow line has an inlet and an outlet. A controllable valve is positioned along the fluid flow line for opening and closing the flow path as desired, and an acoustic displacement transducer having a fluid port is coupled to the fluid flow line upstream from the controllable valve. The outlet of the fluid flow line extends through a wall isolating fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter, thereby preventing the exhausted fluid, if explosive, from contacting such electrical and/or mechanical components which may act as potential ignition sources. Preferably, a manifold having a rigid body is provided in which the fluid flow line is formed. An acoustic displacement transducer (ADT) chamber wall is formed on the manifold body, and has an ADT chamber inlet port formed therein, and the fluid flow line has a branched portion connecting the fluid flow line to the ADT chamber inlet port. The outlet of the fluid flow line extends through a wall formed in the manifold body to isolate fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter. | 01-20-2011 |
James B. Johnston, Ambler, PA US
James B. Johnston, Philadelphia, PA US
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20120179619 | Method for Recouping Tuition Discounts - A tuition advantage program incorporating an award offered to students via a promissory note, and having an original principal balance that replaces a small part of the institutional tuition discount that the institution extends to the student. The principal is a reduction against tuition, and it is not delivered to students in the form of a payment. Extension of the principal therefore results in no direct expense to the institution, as it is merely a transformation of a discount that otherwise would have been granted to the student in the form of institutional aid award. Repayment of the tuition advantage funds is not required until after the student separates from the institution, such as by graduation. Upon separation and timely repayment of the first 75% of the original principal balance, the remaining 25% of the original principal is forgiven, resulting in an effective annual percentage rate of under 1.0%. | 07-12-2012 |
James Richard Johnston, Bethel Park, PA US
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20090269161 | Threaded Fastener - A fastener is provided including an elongated body having a first end and a second end, and a helical thread formed on at least a portion of the elongated body where the thread has a crest, a root, and flank portions. The helical thread has at least one protrusion extending from the crest and flank portions toward the first end of the elongated body, and each protrusion has a peak that extends to the root of the thread. | 10-29-2009 |
20110255936 | Threaded Fastener - A fastener includes an elongated body having a first end and a second end, a helical thread having a crest, a root, and flank portions formed on at least a portion of the elongated body, and at least one protrusion extending from the crest and flank portion. The at least one protrusion is an axially extending V-shape of the crest, flank portions, and root of the helical thread with a peak of the at least one protrusion having a ridge that extends radially outward from the root of the thread. | 10-20-2011 |
20130236267 | Threaded Fastener - A fastener includes an elongated body having a first end and a second end, a helical thread having a crest, a root, and flank portions formed on at least a portion of the elongated body, and at least one protrusion extending from the crest and flank portion. The at least one protrusion is an axially extending V-shape of the crest, flank portions, and root of the helical thread with a peak of the at least one protrusion having a ridge that extends radially outward from the root of the thread. | 09-12-2013 |
Jay Johnston, Clinton, PA US
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20150112010 | SEALANT COMPOSITIONS WITH A POLYURETHANE DISPERSION AND A HYDROXY-FUNCTIONAL COMPOUND - Disclosed are compositions that include (a) an aqueous polyurethane dispersion prepared from an isocyanate-terminated prepolymer; and (b) a hydroxyl-functional compound having an average hydroxyl equivalent weight of greater than 40 gram/equivalent to less than 500 gram/equivalent. Also disclosed are methods of using the compositions as, for example, a sealant. | 04-23-2015 |
20150218372 | ONE-COMPONENT, MOISTURE-CURING COMPOSITION - A one-component composition comprising: | 08-06-2015 |
Jay A. Johnston, Clinton, PA US
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20140058030 | SILANE-TERMINATED POLYURETHANE AND RUBBER COMPOSITE MATERIALS - Composite materials including rubber particles and silane-terminated polyurethane binders are disclosed. | 02-27-2014 |
20140221564 | HYDROPHILIC SEALANTS - The present invention provides water swellable one-component sealants prepared by incorporation of polyols containing ethylene oxide (“EO”) into the backbone of the polymer. The inventive one-component hydrophilic polyurethane sealant contains a silane-terminated polyurethane prepolymer, a compound having an ethylene oxide content of at least about 40 wt. %, based on the weight of the compound and a catalyst, optionally, one or more of plasticizers, fillers, pigments, drying agents, light stabilizers, antioxidants, thixotropic agents and bonding agents. The one-component hydrophilic polyurethane sealant increases at least about 1.4% by weight and at least about 2.5% by volume upon exposure to water for 24 hours and are capable of curing in a high humidity environment (including underwater) without foaming and maintain physical characteristics such as hardness. | 08-07-2014 |
Jay A. Johnston, Pittsburgh, PA US
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20090029042 | Concrete repair process - The present invention provides a process for repairing concrete involving filling one of a void, gap or seam in the concrete with a polyurethane sealant containing a silane terminated prepolymer (“STP”), and a catalyst, optionally, one or more of plasticizers, fillers, pigments, drying agents, light stabilizers, antioxidants. thixotropic agents and bonding agents and applying an isocyanate-terminated prepolymer containing polyurethane or polyurea coating to the silane terminated prepolymer polyurethane sealant. | 01-29-2009 |
20090030145 | Hydrophilic sealants - The present invention provides water swellable one-component sealants prepared by incorporation of polyols containing ethylene oxide (“EO”) into the backbone of the polymer. The inventive one-component hydrophilic polyurethane sealant contains a silane-terminated polyurethane prepolymer, a compound having an ethylene oxide content of at least about 40 wt. %, based on the weight of the compound and a catalyst, optionally, one or more of plasticizers, fillers, pigments, drying agents, light stabilizers, antioxidants. thixotropic agents and bonding agents. The one-component hydrophilic polyurethane sealant increases at least about 1.4% by weight and at least about 2.5% by volume upon exposure to water for 24 hours and are capable of curing in a high humidity environment (including underwater) without foaming and maintain physical characteristics such as hardness. | 01-29-2009 |
20090030161 | Allophanate modified diphenylmethane diisocyanates, prepolymers thereof, and their use in the preparation of polyureas and polyurethanes - This invention relates to novel allophanate-modified diphenylmethane diisocyanates, prepolymers of these allophanate-modified diphenylmethane diisocyanates, and two-component polyureas and one-component polyureaurethanes prepared from these prepolymers. In addition, the invention also relates to processes for the preparation of these various compositions, and to the preparation of sealants from the two-component polyureas and caulking agents from the one-component polyureaurethanes. | 01-29-2009 |
20110263797 | ALLOPHANATE MODIFIED DIPHENYLMETHANE DIISOCYANATES, PREPOLYMERS THEREOF, AND THEIR USE IN THE PREPARATION OF POLYUREAS AND POLYURETHANES - This invention relates to novel allophanate-modified diphenylmethane diisocyanates, prepolymers of these allophanate-modified diphenylmethane diisocyanates, and two-component polyureas and one-component polyureaurethanes prepared from these prepolymers. In addition, the invention also relates to processes for the preparation of these various compositions, and to the preparation of sealants from the two-component polyureas and caulking agents from the one-component polyureaurethanes. | 10-27-2011 |
Jay M. Johnston, Pottsville, PA US
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20100078307 | Anaerobic process for treating organic material to generate biogas - The present invention provides an anaerobic digestion process for the treatment of organic waste materials, which process comprises a bacterial process that is carried out in the absence of oxygen and wherein said process comprises digestion, in which said waste is fermented in tanks at an elevated temperature, and wherein said process results in the production of biogas, which can be used in generators for electricity production and/or in boilers for heating purposes, the comprises treating an organic waste with a composition comprising a fermentation supernatant containing active enzymes from a | 04-01-2010 |
20160102005 | Anaerobic Process for Treating Organic Waste Materials - The present invention provides an anaerobic digestion process for the treatment of organic waste materials, which process comprises a bacterial process that is carried out in the absence of oxygen and wherein said process comprises digestion, in which said waste is fermented in tanks at an elevated temperature, and wherein said process results in the production of biogas, which can be used in generators for electricity production and/or in boilers for heating purposes, the comprises treating an organic waste with a composition comprising a fermentation supernatant containing active enzymes from a | 04-14-2016 |
Kelly Johnston, Harleysville, PA US
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20110288876 | SYSTEM AND METHOD TO ASSIST HEALTH ADVOCATE PROFESSIONALS AND EMPLOYERS - A computer-assisted method for assisting a health advocate professional in counseling employees of a plan sponsor comprising receiving health records of employees of a plan sponsor, analyzing data in the records, displaying the analyzed data for any selected employee in dashboard format, calculating any health improvement options for the selected employee, and displaying the health improvement options in the form of questions to be asked by a health advocate professional viewing the displayed dashboard, preferably arranged in categories under spotlight buttons, and a computer system adapted to carry out the method. The method and system can also provide in some embodiments summary medical benefits usage information to plan sponsors, including costs, health improvement options, return on investment. | 11-24-2011 |
Mark H. Johnston, Lancaster, PA US
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20100249765 | TRACHEOBRONCHIAL PULMONARY CRYOGENIC THERAPEUTIC METHOD AND APPARATUS - Disclosed are methods for the cryoablation treatment of a patients tracheobronchial pulmonary system, such as in the treatment of tracheobronchial lesions and lung cancer. The pulmonary system treatment method employs a specially dimensioned dorsal end catheter system that includes a proximal end suitable to provide for the delivery of a cryogenic material to a desired pulmonary area of interest in a patient. The apparatus includes as a part thereof an endoscope dimensioned so as to be suitable for insertion through a patient's trachea. Provided are tracheobronchial cryoablation methods for treatment of benign airway disease, early lung cancer, sarcoidosis, Wegner's granulomatosis, rhinoscleroma, recurrent respiratory papillomatosis (RRP), benign tracheal stenosis, pulmonary dysplasia, neoplasia, vascular lesions, inflammatory lesions and pulmonary and/or tracheal degenerative lesions. | 09-30-2010 |
Nicholas J. Johnston, Allison Park, PA US
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20160065136 | Modular RF Matrix Switch - An RF matrix switch has a first set of card slots at selected locations on the chassis and a second set of card slots at different selected locations on the chassis as well as input cards and output cards. The input cards, the output cards, the first set of card slots and the second set of card slots are all configured so that the input cards and the output cards fit into all of these slots. Reroute cards can be provided for any unused card slots. The RF matrix switch also may have an active power management system in which there is a power control switch connected to each amplifier that turns the amplifier off when the amplifier is not being used. | 03-03-2016 |
Patricia Johnston, Sewickly, PA US
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20100009352 | Method for Modeling a Disease - The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided. | 01-14-2010 |
Patricia A. Johnston, Sewickly, PA US
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20090170091 | Method For Predicting Biological Systems Responses - The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles. | 07-02-2009 |
Paul A. Johnston, Pittsburgh, PA US
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20140371235 | SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER - A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: | 12-18-2014 |
Sean Johnston, Doylestown, PA US
Patent application number | Description | Published |
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20080287401 | Methods for Synthesizing and Purifying Aminoalkyl Tetracycline Compounds - Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described. | 11-20-2008 |
20090253660 | Minocycline Compounds and Methods of Use Thereof - Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, | 10-08-2009 |
20100056638 | Oral and Injectable Formulations of Tetracycline Compounds - Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention pertains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formulations may be used, for example, to treat infections. | 03-04-2010 |
20100113401 | METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS - Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described. | 05-06-2010 |
Sean M. Johnston, Doylestown, PA US
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20130012480 | CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(ME- THYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-- 2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME - A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed. | 01-10-2013 |
20130302442 | METHODS OF USING (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(ME- THYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-- 2-CARBOXYLIC ACID AMIDE - A method of treating a bacterial infection, e.g., a bacterial infection with methicillin resistant | 11-14-2013 |
20140031319 | METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS - Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described. | 01-30-2014 |
20150087711 | MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF - Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, | 03-26-2015 |
20160030453 | METHODS OF INCREASING ORAL BIOAVAILABILITY OF TETRACYCLINES - Methods for increasing the oral bioavailability of tetracycline compounds are described. | 02-04-2016 |