Johnston, MA
A. Sidney Johnston, Boston, MA US
Patent application number | Description | Published |
---|---|---|
20130042626 | INTEGRATED PLANT FOR ELECTRICAL ENERGY PRODUCTION AND STORAGE - A method for operating an electrical energy storage system is described. Electrical energy is supplied to electrolyze first water to produce hydrogen and oxygen. A turbine is operated from the hydrogen and the oxygen to combine the hydrogen and the oxygen to deliver energy to the turbine by forming second water in a vapor phase in order for the turbine to operate an electric generator to generate electrical energy. The second water is condensed from the vapor phase into a liquid phase as liquid second water. The liquid second water is delivered to be electrolyzed into new hydrogen and new oxygen in order to recirculate the second water for electrolysis into new hydrogen and new oxygen. The electrical energy generated by the electric generator is distributed to customers by means of grid transmission lines. | 02-21-2013 |
Bruce E. Johnston, Brookline, MA US
Patent application number | Description | Published |
---|---|---|
20080207615 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 08-28-2008 |
20080234264 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 09-25-2008 |
20130316935 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 11-28-2013 |
David Johnston, Westford, MA US
Patent application number | Description | Published |
---|---|---|
20120296511 | METHOD & APPARATUS FOR DOCKING A ROBOTIC DEVICE WITH A CHARGING STATION - A docking system includes a mobile robotic device and a charging station to which the robotic device is to dock. The robotic device is comprised of sensors to capture a homing signal emitted by the charging station, docking logic that processes the homing signal so that it can be used to control the movements of the robotic device towards and dock with the charging station, and it is comprised of a mechanism for receiving a cylindrical charging post. The charging station is comprised of a circular platform in the center of which is located the charging post that is generally cylindrical in shape. The charging post includes a charging contact, ground contacts and an IR emitter. The geometry of the receiver mechanism elements and the shape of the charging post and geometry of the charging station generally permits the robotic device to approach the charging station and to dock with the charging station from any angle. | 11-22-2012 |
David Morris Johnston, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20150020239 | SEED-ORIGIN ENDOPHYTE POPULATIONS, COMPOSITIONS, AND METHODS OF USE - This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes. | 01-15-2015 |
Douglas M. Johnston, Winchester, MA US
Patent application number | Description | Published |
---|---|---|
20090298017 | DIGITAL DENTISTRY - The systems and methods disclosed herein employ a scanning system for capturing highly detailed digital dental models. These models may be used within a dentist's office for a wide array of dental functions including quality control, restoration design, and fitting. These models may also, or instead, be transmitted to dental laboratories that may, alone or in collaboration with the originating dentist or other dental professionals, transform the digital model into a physical realization of a dental hardware item. | 12-03-2009 |
20110290005 | DYNAMIC THREE-DIMENSIONAL IMAGING OF EAR CANALS - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 12-01-2011 |
20120231421 | DIGITAL DENTISTRY - The systems and methods disclosed herein employ a scanning system for capturing highly detailed digital dental models. These models may be used within a dentist's office for a wide array of dental functions including quality control, restoration design, and fitting. These models may also, or instead, be transmitted to dental laboratories that may, alone or in collaboration with the originating dentist or other dental professionals, transform the digital model into a physical realization of a dental hardware item. | 09-13-2012 |
20120327426 | INFLATABLE MEMBRANE HAVING NON-UNIFORM INFLATION CHARACTERISTIC - Various improvements to inflatable membranes are disclosed. These improvements include techniques for advantageously controlling the inflation of a membrane within a cavity, such as a human ear canal. | 12-27-2012 |
20120327427 | INFLATABLE MEMBRANE WITH HAZARD MITIGATION - Various improvements to inflatable membranes are disclosed. These improvements include, among other things, features on the membrane that can mitigate hazards such as bubble formation or frictional damage during inflation of the membrane. | 12-27-2012 |
20130002426 | ENHANCED SENSORS IN THREE DIMENSIONAL SCANNING SYSTEM - Various improvements to three dimensional imaging systems having inflatable membranes are disclosed. These improvements include, among other things, a proximity sensor that can be used to warn a user of the device when approaching a feature in a cavity, such as an eardrum in an ear canal; or optical sensors with an optical coating matching the refractive index of the medium in which the optical sensors are deployed, to improve data acquisition. | 01-03-2013 |
20130002824 | INTEGRATED OTOSCOPE AND THREE DIMENSIONAL SCANNING SYSTEM - A multi-purpose device that can be used, as, among other things, an otoscope and a three dimensional scanning system is disclosed. | 01-03-2013 |
20130003078 | THREE DIMENSIONAL SCANNING USING MEMBRANE WITH OPTICAL FEATURES - Various improvements to inflatable membranes for use in three-dimensional imaging of interior spaces are disclosed. These improvements include, among other things, equipping the inflatable membrane with desirable optical features, such as fiducials, optical coatings, etc., that can be used to improve data acquisition. | 01-03-2013 |
20130027516 | CAMERA CONFIGURATION FOR THREE-DIMENSIONAL IMAGING OF INTERIOR SPACES - Various configurations of cameras and cameral elements such as CCDs or the like are disclosed for use in three-dimensional imaging of interior spaces based upon distance measurements. | 01-31-2013 |
20130152670 | IMAGING SHAPE CHANGES IN EAR CANALS - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 06-20-2013 |
20130179120 | SELECTING AN EARPIECE BASED ON DYNAMIC DATA - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 07-11-2013 |
20130182882 | POSITIONING AN INPUT TRANSDUCER FOR AN EARPIECE BASED UPON DYNAMIC DATA - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 07-18-2013 |
20130184846 | USING DYNAMIC DATA TO DETERMINE A MATERIAL PROFILE FOR EARPIECE - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 07-18-2013 |
20130191084 | EVALUATING FIT OF AN EARPIECE BASED ON DYNAMIC DATA - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 07-25-2013 |
20130197888 | SIMULATING EARPIECE FIT BASED UPON DYNAMIC DATA - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain dynamic three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 08-01-2013 |
Erika Johnston, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20120107956 | INDIRECT LATERAL FLOW SANDWICH ASSAY - Disclosed herein are indirect lateral flow sandwich assays, in which the target analyte binds an analyte-specific reagent comprising a first member of a conjugate pair, forming a complex which contacts and binds a colored particulate label comprising a complementary member of said conjugate pair, forming a second complex. Capture of this analyte-comprising, second complex by an immobilized analyte specific capture reagent results in the formation of an immobilized labeled sandwich complex that can be detected. | 05-03-2012 |
Gabriel Johnston, Raynham, MA US
Patent application number | Description | Published |
---|---|---|
20140318299 | STABILIZING APPARATUS FOR HIGHLY ARTICULATED PROBES WITH LINK ARRANGEMENT, METHODS OF FORMATION THEREOF, AND METHODS OF USE THEREOF - An apparatus for driving an articulating probe comprises an elongate probe constructed and arranged to articulate in at least one predetermined degree of motion and to transition from a flexible state to a rigid state, and a force transfer mechanism constructed and arranged to apply a force to the probe. The force is selected from the group consisting of a force that causes probe to articulate in the at least one predetermined degree of motion and a force that causes the probe to transition from the flexible state to the rigid state. The base structure is attached to portion of the force transfer mechanism and the elongate probe; the base structure comprising one or more stabilizing elements constructed and arranged to resist undesired movement of the probe caused by force from the force transfer mechanism. | 10-30-2014 |
Gabriel A. Johnston, Raynham, MA US
Patent application number | Description | Published |
---|---|---|
20130032435 | Lubrication And Exhaust System For A Powered Surgical Instrument - A lubrication cartridge includes a cartridge body. A cartridge coupling is located on the cartridge body and defines a first passage and a second passage. A lubricant reservoir is housed in the cartridge body and comprises a pressurized fluid inlet coupled to the first passage and a lubricant outlet coupled to the second passage. A metering insert is located between the lubricant outlet and the second passage and comprises a density that controls lubricant flow between the lubricant reservoir and the second passage. | 02-07-2013 |
20130274775 | Lubrication And Exhaust System For A Powered Surgical Instrument - A cartridge includes a body, a reservoir, a filter, and a tab. The body is configured to be held in a fixed relationship relative to a stem, wherein the body comprises an inlet and an outlet. The inlet is configured to receive a fluid from a surgical instrument via the stem. The outlet is configured to output a first portion of the fluid from the cartridge. The reservoir is configured to receive the fluid from the inlet. The filter is configured to filter the first portion of the fluid as the first portion of the fluid is directed from the inlet, through the filter, and to the outlet. The tab connected to the body and configured to engage with the stem. The tab is configured to, when the cartridge is moved to disengage from the stem, at least one of break away from the body and become functionally inoperable. | 10-17-2013 |
20140046355 | Motor Assembly For A Powered Surgical Instrument - A surgical instrument is provided for cutting bone and other tissue. The surgical instrument is powered by a pressurized fluid and includes a rotatable shaft connected to a dissection tool. The instrument includes a housing member comprising a one-piece base. A rotor housing chamber is defined by the base, and the rotatable shaft is located in the rotor housing chamber. A first hearing housing is defined by the base, located adjacent the rotor housing chamber, and houses a first bearing that engages the rotatable shaft. A second bearing housing is defined by the base, located on an opposite side of the rotor housing chamber from the first bearing housing, and houses a second bearing that engages the rotatable shaft. A passage is defined by the base and operable to direct a pressurized fluid through the base to the rotor housing chamber in order to rotate the rotatable shaft. | 02-13-2014 |
Jeffrey Johnston, Boston, MA US
Patent application number | Description | Published |
---|---|---|
20130045239 | Method for Modulating the Pharmacodynamic Effect of Orally Administered Guanylate Cyclase Receptor Agonists - A method of modulating the pharmacodynamic effect of a GC-C receptor agonist polypeptide formulation in a subject in need of such treatment is disclosed, The method comprises administering the GC-C receptor agonist polypeptide formulation to the subject before the ingestion of food. | 02-21-2013 |
20130059797 | Linaclotide for the Treatment of Chronic Constipation - The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide. | 03-07-2013 |
20140162963 | Treatment of Constipation-Predominant Irritable Bowel Syndrome - The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide. | 06-12-2014 |
20140349948 | Treatment of Chronic Constipation - The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide. | 11-27-2014 |
Jim Johnston, Newton, MA US
Patent application number | Description | Published |
---|---|---|
20110194029 | TOUCH SENSOR FOR CONTROLLING EYEWEAR - Capacitive touch sensors are integrated with a head-mounted display (HMD) device or other video eyewear devices to create a more reliable and more intuitive user interface. The sensors, which may be implemented as an array, control various aspects of a left and right channel multimedia presentation, such as interpupillary distance or stereoscopic convergence, brightness, volume, or power mode. | 08-11-2011 |
Leslie Johnston, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20130103074 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - A device comprising a single closed loop of elastic filament configurable between (i) a first configuration for movement along a blood vessel; and (ii) a second configuration for lodging within a blood vessel, the second configuration providing a single flow-restricting face sized and configured to cover the mouth of the aneurysm and obstruct blood flow to the aneurysm while permitting substantially normal blood flow through the blood vessel, with the degree of obstruction at the mouth of the aneurysm being such that the aneurysm thromboses when the face is positioned over the aneurysm, the flow-restricting face comprising a plurality of lengths of the closed loop of filament disposed in close proximity to one another in a switchback configuration, and at least one leg for holding the flow-restricting face adjacent the mouth of the aneurysm, the leg configured so as to maintain substantially normal blood flow through the blood vessel. | 04-25-2013 |
Lioyd Johnston, Newton, MA US
Patent application number | Description | Published |
---|---|---|
20140178476 | Highly Efficient Delivery of a Large Therapeutic Mass Aerosol - A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm | 06-26-2014 |
Lloyd Johnston, Newton, MA US
Patent application number | Description | Published |
---|---|---|
20090068274 | HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL - A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm | 03-12-2009 |
20120093893 | Highly Efficient Delivery of a Large Therapeutic Mass Aerosol - A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm | 04-19-2012 |
Lloyd Johnston, Belmont, MA US
Patent application number | Description | Published |
---|---|---|
20110020388 | TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS - This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. | 01-27-2011 |
20110027217 | IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS - This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner. | 02-03-2011 |
20110293700 | NANOCARRIER COMPOSITIONS WITH UNCOUPLED ADJUVANT - Disclosed are synthetic nanocarrier compositions with separate adjuvant compositions as well as related methods. | 12-01-2011 |
20110293701 | MULTIVALENT SYNTHETIC NANOCARRIER VACCINES - The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods. | 12-01-2011 |
20110293723 | SYNTHETIC NANOCARRIER COMBINATION VACCINES - Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are not coupled to the synthetic nanocarriers, and a pharmaceutically acceptable excipient. | 12-01-2011 |
20140030344 | TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOSTIMULATORY AGENTS - This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. | 01-30-2014 |
20140193453 | IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS - This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner. | 07-10-2014 |
20140242173 | TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS - This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. | 08-28-2014 |
Llyod Johnston, Belmont, MA US
Patent application number | Description | Published |
---|---|---|
20100303850 | NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE - This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers. | 12-02-2010 |
Matthew Johnston, Weymouth, MA US
Patent application number | Description | Published |
---|---|---|
20110196775 | Systems, Methods, and Media for Controlling the Exposure of Orders to Trading Platforms - Systems, methods, and media for controlling the exposure of orders to trading platforms are provided. In accordance with some embodiments, systems for controlling the exposure of orders to trading platforms are provided, the systems comprising: at least one hardware processor that: receives information for at least one order to trade a security; and for each of a plurality of trading platforms, determines how the at least one order is to be exposed to trading platform based on at least one of a default exposure setting for all orders for the trading platform, at least one filter for the trading platform, and an exposure status setting for the trading platform and the at least one order, and provides information for the at least one order to the trading platform. | 08-11-2011 |
Meghan M. Johnston, Wakefield, MA US
Patent application number | Description | Published |
---|---|---|
20130224293 | PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions containing a solid dispersion of N—[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. | 08-29-2013 |
20140255483 | PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. | 09-11-2014 |
20150024047 | PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. | 01-22-2015 |
Meghan M. Johnston, Wakefiled, MA US
Patent application number | Description | Published |
---|---|---|
20130195797 | HIGH POTENCY FORMULATIONS OF VX-950 - High potency pharmaceutical compositions comprising VX-950, sodium lauryl sulfate and a polymer selected from the group consisting of hypromellose acetate succinate-M, hypromellose acetate succinate-L and hypromellose acetate succinate-H. | 08-01-2013 |
Steve Johnston, Bolton, MA US
Patent application number | Description | Published |
---|---|---|
20110009424 | Co-Crystals and Pharmaceutical Compositions Comprising the same - The invention relates to co-crystals and compositions each comprising VX-950 and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid. Also within the scope of this invention are methods of making and using the same. | 01-13-2011 |
20110059987 | Co-Crystals and Pharmaceutical Compositions Comprising the Same - The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same. | 03-10-2011 |
Steven C. Johnston, Bolton, MA US
Patent application number | Description | Published |
---|---|---|
20110086891 | Solid Forms of 2-(2,4-Difluorophenyl)-6-(1-(2,6-Difluorophenyl)Ureido)Nicotinamide) - This invention relates to solid forms of 2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith. | 04-14-2011 |
20110230519 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 09-22-2011 |
Thomas M. Johnston, Westborough, MA US
Patent application number | Description | Published |
---|---|---|
20130085478 | CATHETER WITH EXTERNAL FLOW CHANNEL - A catheter is provided which includes a body having a proximal end, a distal end and a sidewall defining at least one lumen. The catheter body has at least one side opening formed through the sidewall at a location spaced proximally from the distal end. The at least one side opening communicates with the at least one lumen. A recess extends along the sidewall and communicates with the at least one side opening such that the recess defines a fluid pathway into the side opening. | 04-04-2013 |
20140257244 | FLUSHING STYLET - Systems and methods for use medical procedures including catheters and stylets are disclosed. The catheter includes a wall having an inner surface and an outer surface, the inner surface defining a lumen, and the wall defining at least one side opening from the outer surface to the inner surface. The stylet includes an elongate body defining a passage and at least one aperture in fluid communication with the passage. The stylet also includes a first blocking dam secured to the elongate body proximal to the at least one aperture and a second blocking dam secured to the elongate body distal to the at least one aperture. The stylet is movable within the lumen to a position in which the first and second blocking dams are, respectively, proximal and distal to the at least one side opening of the catheter and each of the first and second blocking dams is sealingly enaged with the inner surface of the catheter such that fluid introduced into the lumen, from the passage and through the at least one aperture of the stylet, is directed through the at least one side opening of the catheter. | 09-11-2014 |