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| 20110033862 | METHODS FOR CELL GENOTYPING - Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell. | 02-10-2011 |
| 20110092763 | Methods for Embryo Characterization and Comparison - Disclosed herein are methods for determining which embryos from a group of embryos are most likely to implant and develop as desired. In an embodiment of the present disclosure, one or more cells are biopsied from each of the embryos, and the genetic condition of those cells are determined. Within a group of embryos that each test positive for aneuploidy, the likelihood that each embryo contains euploid cells may be determined from the type of aneuploidy observed in the biopsied cells. This knowledge may be used to make a decision as to which embryos to transfer to a uterus. In an embodiment of the present disclosure, these determinations are made for the purpose of embryo selection in the context of in vitro fertilization. | 04-21-2011 |
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| 20120002082 | Capturing and Rendering High Dynamic Range Images - Some embodiments of the invention provide a mobile device that captures and produces images with high dynamic ranges. To capture and produce a high dynamic range image, the mobile device of some embodiments includes novel image capture and processing modules. In some embodiments, the mobile device produces a high dynamic range (HDR) image by (1) having its image capture module rapidly capture a succession of images at different image exposure durations, and (2) having its image processing module composite these images to produce the HDR image. | 01-05-2012 |
| 20120002898 | Operating a Device to Capture High Dynamic Range Images - Some embodiments provide a method of operating a device to capture an image of a high dynamic range (HDR) scene. Upon the device entering an HDR mode, the method captures and stores multiple images at a first image exposure level. Upon receiving a command to capture the HDR scene, the method captures a first image at a second image exposure level. The method selects a second image from the captured plurality of images. The method composites the first and second images to produce a composite image that captures the HDR scene. In some embodiments, the method captures multiple images at multiple different exposure levels. | 01-05-2012 |
| 20120002899 | Aligning Images - Some embodiments provide a method of aligning a pair of images. The method defines multiple different pairs of images at multiple different resolutions. The method hierarchically aligns the original pair of images by first aligning the pair of images at the lowest resolution and then aligning each pair of images at each higher resolution based on the alignments of the pair of images at the lower resolutions. For some of the resolutions, to perform the hierarchically alignment, the method identifies, for at least one image at each resolution, portions that are suitable for performing the alignment and portions that are not suitable for performing the alignment. The method compares each pair of images at a particular resolution by using the suitable portions while excluding the unsuitable portions from the comparison. | 01-05-2012 |
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| 20090182361 | Obstruction Removal System - An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices occurring along a drive belt. The plurality of capture devices may be basket-like devices attached to the drive belt, or may be formed by integral coiled or protuberant sections of the drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes. | 07-16-2009 |
| 20090182362 | Obstruction Removal System - An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices attached to or integral with a drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes. The obstruction removal system may include one or more drive mechanisms, such as a pulley system and/or a vacuum source and/or a pressurization source, on its proximal end for driving the drive belt and capture devices through the catheter in a circulating manner. The obstruction removal system may also include one or more cleaning mechanisms, such as a vacuum chamber and/or a fluid rinse chamber, for removing the captured clot pieces from the capture devices. | 07-16-2009 |
| 20100047210 | Systems and Methods for Positioning of Needles and Other Devices Within Body Tissue - Systems and methods for delivering a substance (e.g., a therapeutic or diagnostic substance, drug, biologic, cells, etc.) or device (e.g., implantable device, sensor, electrode, etc.) to a specific location within a tissue mass (e.g., an organ, tumor, other mass of body tissue, etc.) that is located a spaced distance from an open or fluid-filled space, body cavity or body lumen. | 02-25-2010 |
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| 20100133030 | FRAME FOR A RIDE-ON VEHICLE HAVING A PLURALITY OF BATTERY PACKS - In one embodiment, the invention is a frame for a ride-on vehicle having at least one front wheel, at least one rear wheel, and a plurality of substantially similar battery packs. The frame defines a central plane and includes a front end located adjacent to the front wheel(s), a rear end located adjacent to the rear wheel(s), and a lattice structure that extends substantially between the front end and the rear end. The lattice structure includes a first portion that includes battery pack mounts that secure a first subset of the battery packs arranged in two layers, and includes a second portion that includes battery pack mounts that secure a second subset of the batter packs arranged in a single layer. The lattice structure also defines a truss that mechanically couples the front wheel(s) to the rear wheel(s). | 06-03-2010 |
| 20100136405 | BATTERY PACK WITH OPTIMIZED MECHANICAL, ELECTRICAL, AND THERMAL MANAGEMENT - Disclosed is a multi-cell battery pack system with integrated thermal and electrical management that includes a plurality of cells, a plurality of cradles that each define a channel that extends through the length of the cradle and having an external surface that mechanically positions each of the cells radially around and parallel to the channel, that exchanges heat with the cells and that electrically couples with each of the cells, and an endplate that, when the cradle is mechanically coupled to the endplate, the channel of the cradle is connected to a fluid circuit that routes thermally conductive fluid through the channel to exchange heat with the channel and the cells are connected to an electrical circuit. | 06-03-2010 |
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| 20110259660 | FRAME FOR A TWO WHEELED ELECTRIC VEHICLE - A frame for an electric vehicle with a motor and a transmission, the frame including a steering head unit, a power unit casing, a left side frame and a right side frame. The steering head unit includes a steering head, a left extension and a right extension, wherein the left extension and right extension extend at an angle from the steering head. The power unit casing encloses the motor and the transmission, orienting the gearbox of the transmission vertically underneath the motor. The left and right side frames mount, on one end, to the left and right extensions of the steering head unit, respectively, wherein the other end mounts to the left and right sides of the power unit casing, respectively. The steering head unit, the power unit, the left side frame and the right side frame form an open cage, configured to accept a battery assembly. | 10-27-2011 |
| 20110262785 | BATTERY MODULE - A battery module that includes a battery unit composed of a plurality of flat cells and having an end face, a container with an end piece that encloses the battery unit, and a damping assembly disposed between the end face and the end piece. The damping assembly includes a pressure plate, coupled to the end face, that distributes a force substantially equally over the end face. The damping assembly further includes a damping mechanism that damps battery unit oscillations within the container and applies the force to the pressure plate. Coupling the end plate to the damping mechanism compresses the damping mechanism, and causes the damping mechanism to exert a reactionary force against the pressure plate. Furthermore, the damping assembly compresses and substantially suspends the battery unit within the container, such that one face of the battery unit does not substantially contact the container interior. | 10-27-2011 |
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| 20080312270 | COMPOUNDS AND METHODS USEFUL FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION - Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives. | 12-18-2008 |
| 20100331293 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 12-30-2010 |
| 20100331306 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 12-30-2010 |
| 20110319378 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 12-29-2011 |
