Patent application number | Description | Published |
20080240535 | Systems And Methods For Multi-Modal Imaging - The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection. | 10-02-2008 |
20080308744 | Serum Albumin Conjugated to Fluorescent Substances for Imaging - Compositions and methods are disclosed for imaging tissue or a lymphatic or circulatory system, for example, in the near infrared. Dyes that emit wavelengths in the infrared or near infrared regions of the spectrum may be employed on their own, as combinations or complexed with serum albumin, or as part of a covalent conjugate with serum albumin. | 12-18-2008 |
20090027280 | MICRO-SCALE RESONANT DEVICES AND METHODS OF USE - The invention relates to micro-resonant devices (MRDs) that generate resonance at radio frequencies not present in an animal or human body, or present at low, background levels in the body. These individual, often monolithic devices, can be located in three-dimensional space and tracked anywhere in a target area, e.g., in a human or animal body, or within a cell within a body, using a conventional magnetic resonance imaging (MRI) scanner or other transducers, e.g., radiofrequency transducers. The MRDs generate high sensitivity contrast in conventional clinical MRI scanners, have a diameter of anywhere from a few nanometers to 1000 microns, and can in some embodiments be manufactured using Micro-Electro-Mechanical Systems (MEMS) technology. The devices are optionally coated to isolate them from the environment, and this coating can be a biocompatible coating for medical and biotechnology uses. | 01-29-2009 |
20090123383 | Non-Isotopic Detection of Osteoblastic Activity In Vivo Using Modified Bisphosphonates - The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures. | 05-14-2009 |
20090137902 | Intraoperative imaging methods - Described are methods for intraoperative imaging of anatomical structures using fluorescent compounds, e.g., compounds that fluoresce in the invisible light (IL) region of the spectrum, i.e., above 670 nm. An exemplary compound is methylene blue. | 05-28-2009 |
20090161928 | SYSTEM AND METHOD FOR UNSUPERVISED DETECTION AND GLEASON GRADING OF PROSTATE CANCER WHOLE MOUNTS USING NIR FLUORSCENCE - A method for unsupervised classification of histological images of prostatic tissue includes providing histological image data obtained from a slide simultaneously co-stained with NIR fluorescent and Hematoxylin-and-Eosin (H&E) stains, segmenting prostate gland units in the image data, forming feature vectors by computing discriminating attributes of the segmented gland units, and using the feature vectors to train a multi-class classifier, where the classifier classifies prostatic tissue into benign, prostatic intraepithelial neoplasia (PIN), and Gleason scale adenocarcinoma grades 1 to 5 categories. | 06-25-2009 |
20090269283 | METHOD AND PRODUCT FOR LOCATING AN INTERNAL BLEEDING SITE - A method is provided for localizing an internal bleeding site whereby a protein or other factor involved in the clotting process is complexed to an imaging agent and injected into a patient believed to be at risk of internal bleeding. A clot in the patient will naturally accumulate a certain concentration of the injected complex, and within a short period of time the concentration becomes sufficient to be detected by an imaging apparatus. The imaging contrast agent may, for example, be an MRI contrast agent, a CT contrast agent, a PET agent, or a fluorescent substance. | 10-29-2009 |
20100040547 | DYES AND PRECURSORS AND CONJUGATES THEREOF - Novel dyes, precursors to novel dyes, and conjugates of the novel dyes are disclosed, as well as methods of making and using the same. | 02-18-2010 |
20100202965 | ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS - The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a | 08-12-2010 |
20100215585 | DYES AND PRECURSORS AND CONJUGATES THEREOF - Novel dyes, precursors to novel dyes, and conjugates of the novel dyes are disclosed, as well as methods of making and using the same. | 08-26-2010 |
20100262017 | MULTI-CHANNEL MEDICAL IMAGING SYSTEM - A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest. | 10-14-2010 |
20100305455 | DEVICE FOR WAVELENGTH-SELECTIVE IMAGING - An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths. | 12-02-2010 |
20110033379 | RADIO-LABELED MATERIALS AND METHODS OF MAKING AND USING THE SAME - Radio-labeled materials, e.g., compounds and compositions, methods of making the radio-labeled materials, and applications of the same are disclosed. For example, novel solid-state methods are disclosed that produce radio-labeled compositions that include a reactive, but stable radio-labeled compound in a polar anhydrous solvent. The radio-labeled compounds can be readily conjugated with a variety of ligands. | 02-10-2011 |
20110040169 | INTEGRATION OF MICRO AND MACRO INFORMATION FOR BIOMEDICAL IMAGING - Macroscopic imaging data, such as from a CT, MR, PET, or SPECT scanner, is obtained. Microscopic imaging data of at least a portion of the same tissue is obtained. To align the microscopic imaging data with the macroscopic imaging data, intermediate data is also obtained. For example, photographic data is acquired at an intermediary stage of a process of preparing tissue for microscopic scan. The macroscopic and microscopic data are registered to the intermediary photographic data. Once registered to the intermediary data, the spatial relationship between the macroscopic and microscopic data is known and may be used for imaging or quantification. | 02-17-2011 |
20110256065 | Non-Isotopic Detection of Osteoblastic Activity In Vivo Using Modified Bisphosphonates - The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures. | 10-20-2011 |
20120028291 | CHARGED-BALANCED IMAGING AGENTS - The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio. | 02-02-2012 |
20130243292 | NETWORK CYCLE FEATURES IN RELATIVE NEIGHBORHOOD GRAPHS - Methods for analyzing biomedical data include: (a) obtaining macroscopic imaging data; (b) obtaining histopathological imaging data; (c) executing a parallel algorithm stored on a non-transient computer-readable medium to compute one or a plurality of network cycle features of a relative neighborhood graph derived from the histopathological imaging data; (d) registering the macroscopic imaging data and the histopathological imaging data; and (e) correlating the macroscopic imaging data and the network cycle features. Systems for analyzing biomedical data and computer readable storage media are described. | 09-19-2013 |
20130243352 | Global Error Minimization In Image Mosaicking Using Graph Laplacians And Its Applications In Microscopy - An image mosaicking method includes performing pairwise registration of a plurality of tiles ( | 09-19-2013 |
20140073885 | MULTI-CHANNEL MEDICAL IMAGING SYSTEM - A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest. | 03-13-2014 |