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| 20090146016 | Trailing edge device catchers and associated systems and methods - Trailing edge device catchers and associated systems and methods are disclosed. A system in accordance with one embodiment includes a wing having a wing support, a trailing edge device carried by and movable relative to the wing and having a device support, and a coupling connected between the wing and the trailing edge device. The coupling can include a pivot joint that includes a pivot element aligned along a pivot axis and connected between the wing support and the device support. The coupling can further include an actuator coupled between the wing and the trailing edge device, with the actuator having a first position in which the trailing edge device is stowed, and a second position in which the trailing edge device is deployed, with an air flow gap located between the wing and the trailing edge device when the trailing edge device is in the second position. A cam track is carried by one of the wing and the trailing edge device and has opposing cam track surfaces fixed relative to each other. A cam is carried by the other of the wing and trailing edge device and is positioned within the cam track between the opposing cam track surfaces. The cam is offset from the pivot axis and during normal operation the cam can carry no load or a first load along a load path that includes the cam track, and when a decrease in support provided by at least one of the pivot element, the wing support and the device support occurs, the cam can carry a second non-zero load greater than the first load along the load path. | 06-11-2009 |
| 20100170998 | AIRCRAFT TRAILING EDGE DEVICES, INCLUDING DEVICES HAVING FORWARDLY POSITIONED HINGE LINES, AND ASSOCIATED METHODS - Aircraft trailing edge devices, including devices having forwardly positioned hinge lines, and associated methods are disclosed. An aircraft system in accordance with one embodiment of the invention includes a wing and a trailing edge device coupled to the wing. The trailing edge device can be movable relative to the wing between a stowed position and a deployed position, with the trailing edge device having a leading edge, a trailing edge, an upper surface, and a lower surface. The upper surface can have an intersection point with the wing when the trailing edge device is in the stowed position. The motion of the trailing edge device relative to the wing can include rotational motion about a hinge line positioned forward of the intersection point, and a gap can be positioned between the trailing edge of the wing and the leading edge of the trailing edge device when the trailing edge device is in the deployed position. | 07-08-2010 |
| 20120018588 | Aircraft Trailing Edge Devices, Including Devices Having Forwardly Positioned Hinge Lines, and Associated Methods - Aircraft trailing edge devices, including devices having forwardly positioned hinge lines, and associated methods are disclosed. An aircraft system in accordance with one embodiment of the invention includes a wing and a trailing edge device coupled to the wing. The trailing edge device can be movable relative to the wing between a stowed position and a deployed position, with the trailing edge device having a leading edge, a trailing edge, an upper surface, and a lower surface. The upper surface can have an intersection point with the wing when the trailing edge device is in the stowed position. The motion of the trailing edge device relative to the wing can include rotational motion about a hinge line positioned forward of the intersection point, and a gap can be positioned between the trailing edge of the wing and the leading edge of the trailing edge device when the trailing edge device is in the deployed position. | 01-26-2012 |
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| 20090124668 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes modulators of MCP-1 of formula (I): | 05-14-2009 |
| 20090298833 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed. | 12-03-2009 |
| 20100113489 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY, CRYSTALLINE FORMS AND PROCESS - The present invention provides a novel antagonist or partial agonists/antagonist of MCP-1 receptor activity: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin- 4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having an unexpected combination of desirable pharmacological characteristics. Crystalline forms of the present invention are also provided. Pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases is also an objective of this invention. The present disclosure also provides a process for preparing compounds of Formula (I), including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide: | 05-06-2010 |
| 20100204274 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R | 08-12-2010 |
| 20110082113 | PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes prodrugs of the compound of formula (I): | 04-07-2011 |
| 20110245226 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed. | 10-06-2011 |
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| 20090082689 | METHOD AND APPARATUS FOR REDUCING THE NUMBER OF CHANNELS IN AN EEG-BASED EPILEPTIC SEIZURE DETECTOR - An ambulatory patient-specific epileptic seizure detector based on scalp EEG signals is presented. A method for selecting a patient-specific subset of electrodes from a plurality of m EEG channels needed to detect an epileptic seizure in the patient is also presented. Seizure EEG data is collected from the plurality of m EEG channels. An effective subset n of the channels of the plurality of m EEG channels is selected using recursive feature processing and a detector is constructed in response to the subset n of channels. The performance of the detector in detecting seizures is then estimated. | 03-26-2009 |
| 20090192394 | Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal - A method and apparatus for predicting patient outcome from a physiological segmentable signal of a patient. In one embodiment, the method comprises the steps of obtaining the physiological segmentable signal of the patient; segmenting the physiological segmentable signal into a plurality of separate segmentable components; calculating a time series of the morphological distance between adjacent separate segmentable components of the plurality of separate segmentable components; and predicting patient outcome in response to the time series of the morphological distance. In another aspect, the invention relates to a method for extracting information from physiological signals for one or more subjects including the steps of partitioning the physiological signal into a plurality of components, grouping the components into a plurality of information classes, assigning a unique symbol to each information class, mapping each component to the assigned symbol, and examining one or more such sequences for clinical significance. | 07-30-2009 |
| 20100016743 | Identifying Groups of Patients with Similar Physiological Characteristics and Risk Profiles - The invention relates in part to methods for partitioning a plurality of patients into risk profile groups comprising the steps of: recording a physiological signal from each patient of a plurality of patients; segmenting the physiological signal into a plurality of components for each patient of a plurality of patients; grouping the components into a plurality of information classes for each patient of a plurality of patients; assigning a representation to each information class for each patient of a plurality of patients; and grouping the patients in response to the representations of their respective information classes. | 01-21-2010 |
| 20100016748 | Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements - The application relates a methodology and apparatus for identifying predictive patterns for acute clinical events in the absence of prior knowledge. Principles of conservation are used to identify activity that consistently precedes an outcome in patients, and describe a two-stage process that allows us to more efficiently search for such patterns in large datasets. This is achieved by first transforming continuous physiological signals from multiple patients into symbolic sequences, and by then searching for patterns in these reduced representations that are strongly associated with an outcome. | 01-21-2010 |
| 20110257517 | Patient-Specific Seizure Onset Detection System - The present invention provides methods and systems for patient-specific seizure onset detection. In one embodiment, at least one EEG waveform of the patient is recorded, and at least one epoch (sample) of the waveform is extracted. The waveform sample is decomposed into one or more subband signals via a wavelet decomposition of the waveform sample, and one or more feature vectors are computed based on the subband signals. A seizure onset can then be identified based on classification of the feature vectors to a seizure or a non-seizure class by comparing the feature vectors with a decision measure previously computed for that patient. The decision measure can be derived based on reference seizure and non-seizure EEG waveforms of the patient. In another aspect, similar methodology is employed for automatic detection of alpha waves. In other aspects, the invention provides diagnostic and imaging systems that incorporate the above seizure-onset and alpha-wave detection methodology. | 10-20-2011 |
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| 20110302979 | LUBRICATION PROCESSES FOR ENHANCED FORGEABILITY - Forge lubrication processes are disclosed. A solid lubricant sheet is placed between a workpiece and a die in a forging apparatus. Force is applied to the workpiece with the die to plastically deform the workpiece. The solid lubricant sheet decreases the shear friction factor for the forging system and reduces the incidence of die-locking. | 12-15-2011 |
| 20120060981 | Processing Routes for Titanium and Titanium Alloys - Methods of refining the grain size of titanium and titanium alloys include thermally managed high strain rate multi-axis forging. A high strain rate adiabatically heats an internal region of the workpiece during forging, and a thermal management system is used to heat an external surface region to the workpiece forging temperature, while the internal region is allowed to cool to the workpiece forging temperature. A further method includes multiple upset and draw forging titanium or a titanium alloy using a strain rate less than is used in conventional open die forging of titanium and titanium alloys. Incremental workpiece rotation and draw forging causes severe plastic deformation and grain refinement in the titanium or titanium alloy forging. | 03-15-2012 |
| 20120076686 | HIGH STRENGTH ALPHA/BETA TITANIUM ALLOY - An alpha/beta titanium alloy comprising, in percent by weight based on total alloy weight: 3.9 to 4.5 aluminum; 2.2 to 3.0 vanadium; 1.2 to 1.8 iron; 0.24 to 0.30 oxygen; up to 0.08 carbon; up to 0.05 nitrogen; up to 0.015 hydrogen ; titanium; and up to a total of 0.30 of other elements. A non-limiting embodiment of the alpha/beta titanium alloy comprises an aluminum equivalent value in the range of 6.4 to 7.2, exhibits a yield strength in the range of 120 ksi (827.4 MPa) to 155 ksi (1,069 MPa), exhibits an ultimate tensile strength in the range of 130 ksi (896.3 MPa) to 165 ksi (1,138 MPa), and exhibits a ductility in the range of 12 to 30 percent elongation. | 03-29-2012 |
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| 20100232988 | TETHERED AIRFOIL METHODS AND SYSTEMS - The present invention relates to methods and compositions for power generation using a tethered airfoil. In particular, the present invention provides a cost effective, environmentally friendly alternative to generate power for the oil, water, and electric industries or any other application where power is desired. | 09-16-2010 |
| 20100313612 | Low-cost switch sensor remote dead bolt status indicator - A low-cost switch sensor remote dead bolt status indicator includes a switch sensor which starts a transmitter at a door lock location upon sensing of a dead bolt entering into a locked position. The transmitter is provided with a self shut-off feature operating after a fixed duration of minutes length has elapsed. The indicator also includes a receiver in a hand held unit, such as a key fob capable of receiving signals from the transmitter after the user presses an inquiry key on its surface. The hand held receiver having two indicators for alternately displaying the lock's dead bolt status as being locked or unlocked. In an alternate embodiment, the switch sensor is provided as an integral part bonded to the conventional manufactured metal strike plate dead bolt frame that is typically attached to the door jamb. | 12-16-2010 |
| 20100315233 | Dead bolt lock reminder triggered by proximity detector - A deadbolt lock reminder system includes a normally closed deadbolt detector switch which supplies power to a proximity detector to detect a presence of a person in a vicinity of a door whenever the dead bolt is detected not to be in a locked position. When the person leaves the vicinity of the door, the proximity detector switches into a “person no longer detected” mode thereby triggering an alarm. The sounding of the alarm will remind the person to return to lock the dead bolt. The alarm sounds for a fixed duration while the person is still within earshot of the alarm. | 12-16-2010 |
| 20100328089 | Dead bolt lock reminder using passive receiver - A dead bolt lock reminder system includes a dead bolt lock mechanism including a dead bolt for mounting in a door to be secured in a closed door state and a transmitter subsystem constructed for positioning proximate the deadbolt lock mechanism and which further includes a transmitter and a detector. The detector is configured for detecting when the dead bolt is moved from a locked state position to an unlocked state position and from an unlocked state position to a locked state position and where the transmitter is configured for transmitting a dead lock reminder signal identifying that a state of the dead bolt has changed to one of locked and unlocked upon detection of same by the detector. A hand held receiver subsystem is configured to receive the dead lock reminder signal at a time of transmission, and maintain a status of a last change to a locked or an unlocked state for displaying to a user of the hand held receiver subsystem. | 12-30-2010 |
| 20110077113 | Pass-through PTO mechanism for renewable engergy systems - A pass-through power take-off (PTO) mechanism for use with renewable energy systems is described to extract power from a linearly moving tether under high tension and to convert it to rotary power such as for driving an electric generator. Three such embodiments are described. The first uses two adjacent timing belts and transfers power from tether to PTO via friction. The second embodiment uses two adjacent roller chain loops and a mechanical engagement method to transfer power from tether to PTO. The third embodiment uses two adjacent double-sided timing belts and either a synchronous or an asynchronous method to transfer power from the tether to the PTO. | 03-31-2011 |
| 20120017365 | SAFETY SWIMMING POOL APPARATUS - Apparatus usable with a safety swimming pool incorporating a buoyant submersed rescue floor is described. In one instance, a winch coupling a gear motor to a cable drum via an electrically disengageable clutch is used as a device to re-deploy the buoyant floor to the bottom after a rescue. In another instance a solar powered dedicated power supply is used to power the trigger/sensor subsystem. In yet another instance an electro-mechanical circuit for sensing and triggering a rescue episode is described. | 01-26-2012 |
