| Patent application number | Description | Published |
|---|
| 20080208167 | METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS - Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structural reinforcing agents such as those agents containing aloe-derived pectin. In other embodiments, the structural reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents. | 08-28-2008 |
| 20080268019 | Biohybrid elastomeric scaffolds and methods of use thereof - Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided. | 10-30-2008 |
| 20090035350 | Polymers for implantable devices exhibiting shape-memory effects - The present invention is directed to polymeric compositions comprising a biodegradable copolymer that possesses shape-memory properties and implantable devices (e.g., drug-delivery stents) formed of materials (e.g., a coating) containing such compositions. The polymeric compositions can also contain at least one non-fouling moiety, at least additional biocompatible polymer, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric compositions are formulated to possess good mechanical, physical and biological properties. Moreover, implantable devices formed of materials comprising such compositions can be delivered to the treatment site in a conveniently compressed size and then can expand to dimensions appropriate for their medical functions. | 02-05-2009 |
| 20090036978 | Bioabsorbable coating with tunable hydrophobicity - The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases. | 02-05-2009 |
| 20090075933 | CYTOCOMPATIBLE ALGINATE GELS - The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy. | 03-19-2009 |
| 20090081293 | SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I. | 03-26-2009 |
| 20100063570 | COATING ON A BALLOON COMPRISING A POLYMER AND A DRUG - A coating on a balloon of a medical device is provided. The coating comprises a drug and a polymer. Also provided are methods of forming and using the coating. | 03-11-2010 |
| 20100076377 | Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery - An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site. | 03-25-2010 |
| 20100076401 | Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery - The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same. | 03-25-2010 |
| 20100081992 | Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery - An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site. | 04-01-2010 |
| 20100189876 | Balloon Catheter for Delivering Therapeutic Agents - A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit desirable delivery of a substance from the micropores of the coating and into the tissue of a patient's lumen. | 07-29-2010 |
| 20100226955 | POLYMER FOR CREATING HEMOCOMPATIBLE SURFACE - A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided. | 09-09-2010 |
| 20100324645 | DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE - A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue. | 12-23-2010 |
| 20100331819 | Drug Delivery System and Method of Treatment of Vascular Diseases Using Photodynamic Therapy - This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site. | 12-30-2010 |
| 20110009949 | Nanoparticle loaded electrospun implants or coatings for drug release - Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed. | 01-13-2011 |
| 20110143014 | COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 06-16-2011 |
| 20110144577 | HYDROPHILIC COATINGS WITH TUNABLE COMPOSITION FOR DRUG COATED BALLOON - A tunable coating formulation is described for a drug delivery balloon comprising a therapeutic agent, an excipient and a plasticizer. The tunable coating includes a first therapeutic agent and a first excipient, and can have a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. The plasticizer in the formulation has a weigh ratio of excipient to plasticizer below 1:0.1. | 06-16-2011 |
| 20110144578 | HYDROPHOBIC THERAPUEUTIC AGENT AND SOLID EMULSIFIER COATING FOR DRUG COATED BALLOON - The disclosed subject matter is directed to a coated medical device such as a balloon or stent and methods of manufacturing the device, where the device has a working length disposed between a distal end and a proximal end thereof; and a coating applied to at least a length of the body. The coating includes a hydrophobic therapeutic agent having a water solubility less than about 15.0 μg/ml and an emulsifier that is a solid at ambient temperature. | 06-16-2011 |
| 20110144582 | COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 06-16-2011 |
