Patent application number | Description | Published |
20080214569 | Use of phosphatases to treat tumors overexpressing N-CoR - This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme. | 09-04-2008 |
20090018142 | Use of phosphatases to treat tumors overexpressing N-CoR - This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme. | 01-15-2009 |
20090035292 | Use of phosphatases to treat neuroblastomas and medulloblastomas - Disclosed herein are methods of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a phosphatase ligand in an amount effective to treat the subject. Also disclosed herein are method of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a histone deacteylase ligand in an amount effective to treat the subject. | 02-05-2009 |
20090036309 | Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use - This invention provides compounds having the structure | 02-05-2009 |
20090143445 | HDAC Inhibitors - This invention provides the compound having the structure | 06-04-2009 |
20100029484 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use - This invention provides compounds having the structure | 02-04-2010 |
20100029640 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases - Disclosed herein are methods of treating neurodegenerative diseases comprising administering to the subject a compound having the structure: | 02-04-2010 |
20100029683 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses - Disclosed herein are methods of inhibiting proliferation of a cancer cell or inducing apoptosis of a cancer cell, which does not overexpress N—CoR. Also disclosed herein are methods of inhibiting proliferation or inducing apoptosis of a cancer cell that overexpresses TCTP and methods for determining whether a compound is effective in inducing cell death. | 02-04-2010 |
20110287537 | NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES - Disclosed herein are methods of treating neurodegenerative diseases comprising administering to the subject a compound having the structure: | 11-24-2011 |
20120135522 | METHODS OF MODULATING CELL REGULATION BY INHIBITING P53 - Disclosed herein are methods of inhibiting the function of p53 in a cell by contacting the cell with an effective amount of a PP2A inhibitor. Also disclosed herein are processes for producing an induced pluripotent stem (iPS) cell by contacting a somatic cell expressing at least one gene that encodes a reprogramming factor with an amount of a PP2A inhibitor effective to produce the iPS cell; reversibly inhibiting p53 function during production of an iPS cell by contacting a somatic cell with an amount of a PP2A inhibitor effective to reversibly inhibit p53 function; increasing the likelihood of producing an (iPS) cell. | 05-31-2012 |
20120178783 | HDAC INHIBITORS - This invention provides the compound having the structure | 07-12-2012 |
20120264764 | Oxabicycloheptanes and Oxabicycloheptenes, Their Preparation and Use - This invention provides compounds having the structure | 10-18-2012 |
20120270736 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE - This invention provides compounds having the structure | 10-25-2012 |
20130280210 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE - Disclosed herein are methods of inhibiting proliferation of a cancer cell or inducing apoptosis of a cancer cell, which does not overexpress N—CoR. Also disclosed herein are methods of inhibiting proliferation or inducing apoptosis of a cancer cell that overexpresses TCTP and methods for determining whether a compound is effective in inducing cell death. | 10-24-2013 |
20130302402 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE - This invention provides compounds having the structure | 11-14-2013 |
20140235649 | USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION - A method of treating a mammalian subject afflicted with a disease characterized by a loss of protein function caused by a genetic abnormality associated with the disease comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2A inhibitor or a histone deacetylase inhibitor. | 08-21-2014 |
20150045373 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE - This invention provides compounds having the structure | 02-12-2015 |