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John, NY

Beena John, Rochester, NY US

Patent application numberDescriptionPublished
20100015125METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE MEMORY BY BLOCKING INTRAHEPATIC ACTIVATED T CELL DELETION - The present invention discloses a method of inhibiting CD8+ T cell deletion by the liver via the use of Toll-like receptor-4 inhibitors. Also disclosed are compositions of Toll-like receptor-4 inhibitors and either immunogenic agents or activated CD8+ T cells, which can be used to enhance secondary immune responses in normal and immunocompromised subjects. The administration of Toll-like receptor-4 inhibitors, alone or in combination with one or both of immunogenic agents or activated CD8+ T cells, to subjects to enhance secondary immune responses is also disclosed.01-21-2010

Beth John, West Babylon, NY US

Patent application numberDescriptionPublished
20100233284METHOD AND COMPOSITION FOR TREATMENT OF YEAST INFECTION THROUGH A RADIAL APPLIANCE OR A WET-CELL BATTERY APPLIANCE AND SOLUTION JAR SET - Provided are a composition and method of increasing health of the human body includes placing a composition inside a solution jar of a solution jar assembly, wherein the composition comprises at least one of a garlic solution comprising garlic extract, ethanol, and water; a 09-16-2010

David Joshua John, New York, NY US

Patent application numberDescriptionPublished
20080264955Adaptive Drinkware. - Vessels systems are disclosed which change their shape as a function of their environment. This can include adopting to the amount of fluid held by the drinkware or the surface upon which it resides. The drinkware is therefore designed well for reside on both flat and irregular surfaces. As mass is added or removed from a vessel portion, a support system provides features such as measure, signaling, increased stability, and associated entertainment value corresponding to such features. The support system can serve to lower the center of gravity of a vessel when it is relatively full compared to when it is relatively empty.10-30-2008

Erwin John, Mamaroneck, NY US

Erwin R. John, Mamaroneck, NY US

Patent application numberDescriptionPublished
20090312663System and Method for Neurometric Analysis - A system, comprises a plurality of neurometric analyzing software modules operating on electroencephalogram (EEG) data, each module performing a defined task with respect to neurometric analysis of the EEG data and a database including normative neurometric data in combination with a server including an authorization module, the authorization module comparing data received from a remote user to determine whether the user is authorized to utilize any of the plurality of analyzing software modules and an analysis module configured to receive input data from a patient and select one of the neurometric analyzing modules based on the input data, wherein the selected one of the neurometric analyzing modules compares the input data to the normative neurometric data to generate an output, the analysis module selecting the one of neurometric analyzing modules from a set of subscribed neurometric analyzing modules.12-17-2009
20100185185System and Method for Correction of Intracerebral Chemical Imbalances - A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit. A system for treating disorders of the central nervous system (CNS), comprises first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient's CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS and a first reservoir imlpantable within the patient's body and holding material to be introduced to the CNS in combination with a first pump coupled to the first reservoir and the first conduit for introducing the material to the CNS via the first conduit and a brain wave detection unit for detecting and analyzing brain waves of the patient.07-22-2010
20100224188System and Method for Guidance of Anesthesia, Analgesia and Amnesia - A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.09-09-2010
20110160607QEED-Guided Selection and Titration of Psychotropic Medications - Data corresponding to brain electrical activity of a patient from a QEEG is processed to determine which brain activity data deviates from that of a normative profile. The deviant brain activity data is used to determine a brain state vector (BSV) in a multidimensional brain electrical signal space, wherein the orientation of the BSV indicates the nature of the deviation from a normal state and may be used to prescribe a medicine to the patient and wherein the length of the BSV quantifies the degree of abnormality exhibited by the patient and may indicate the dosage of the medicine to be prescribed to the patient.06-30-2011
20110162645System and Method for Guidance of Anesthesia, Analgesia and Amnesia - Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories. The system also includes a display outputting the trajectories for the at least two different indices of anesthetic state of the patient to a user for consideration in formulating subsequent dosages of the interventional agents to be administered to the patient.07-07-2011
20110172553QEEG Statistical Low Resolution Tomographic Analysis - A system and method for analyzing electrophysical signals produced by a brain involves comparing a first selected one of the numerical values to control data including one of a self-norm and a population-norm associated with electrophysical activity in a brain region corresponding to a brain region of origin of the electrophysical activity on which the numerical value is based; calculating a standard score for the brain region of origin based on the comparing; and repeating the comparing and calculating operations for a second selected one of the numerical values, the regions of the brain including subcortical regions extending to a brain stem of the brain.07-14-2011

Patent applications by Erwin R. John, Mamaroneck, NY US

Erwin Roy John, New York, NY US

Patent application numberDescriptionPublished
20080223656Self-deploying automatic inflatable fire escape (SAFE) - This invention provides a reliable means for rapid escape from a burning building when usual exits are dangerous, deploying a safe exit quickly and without requiring the child or adult user to possess unusual presence of mind, strength, manual dexterity or mechanical ability to deploy the apparatus, trained coordination or physic agility to descend. The Self-deploying Automatic inflatable Fire Escape (SAFE) is a building component containing a compressed and folded slide that is installed into an edifice during construction as an integral part of a window casement or wall, or is retrofitted under a pre-existing window, and is automatically deployed by equipment which detects a dangerous condition, sounds and alarm, notifies emergency organizations by a dial-up, opens an aperture in the wall and extends the slide by opening a valve and releasing compressed gas into an inflatable volume which is distended to become a walled chute to the ground.09-18-2008

Erwin Roy John, Mamaroneck, NY US

Patent application numberDescriptionPublished
20080249430System and Method for Pain Detection and Computation of a Pain Quantification Index - A method of detecting pain in a subject, comprises the steps of generating brain wave data based on brain wave activity of the subject and comparing the brain wave data to reference data to generate result data, the reference data corresponding to at least one of (i) population normative data indicative of brain wave activity of a first plurality of individuals in an absence of pain, (ii) population reference data indicative of brain wave activity of a second plurality of individuals generated in response to pain events inflicted on the second plurality of individuals, (iii) subjective population reference data indicative of brain wave activity of a third plurality of individuals reporting a sensation of pain, and (iv) population of reference data indicative of brain wave activity of a fourth population of individuals following an intervention which has changed a subjective report of pain in combination with determining a presence of pain experienced by the subject as a function of the result data.10-09-2008
20090076407Brain Function Scan System - A portable EEG (electroencephalograph) instrument, especially for use in emergencies and brain assessments in physicians' offices, detects and amplifies brain waves and converts then into digital data for analysis by comparison with data from normal groups. In one embodiment, the EEG electrodes are in a headband which broadcasts the data, by radio or cellular phone, to a local receiver for re-transmission and/or analysis. In another embodiment, the subject is stimulated in two modes, i.e., aural and sensory, at two different frequencies to provide the subject's EPs (Evoked Potentials), assessing transmission through the brainstem and thalamus.03-19-2009
20100286549System and Method for Assessing Efficacy of Therapeutic Agents - A method for assessing an effect of a therapeutic agent, comprises the steps of detecting brain electrical activity of a subject to generate a first set of brain wave data and extracting from the first set of brain wave data first data features sensitive to a neurological disorder in combination with the steps of comparing the first data features to control data to define a baseline profile of brain electropathophysiology and computing one of a first classifying score and a first discriminant score based on the baseline profile to estimate a probability that the baseline profile corresponds to a predetermined pathophysiological condition.11-11-2010
20110118618Electronic Identity Card - A method comprises the steps of obtaining a baseline measurement corresponding to a representation of brain activity from a living body and storing the baseline measurements on a storage device configured to be wearable on the living body in combination with obtaining, at a time subsequent to the baseline measurement, a second measurement representing brain activity from the living body, reading the baseline measurement from the storage device and evaluating the living body based on a comparison of the second measurement to the baseline measurement. A system for analyzing electrical brain activity, the system comprises a component for reading, from a storage medium, data corresponding to a baseline measurement of brain activity of a living body and a component for determining data representing a current brain activity of the living body in combination with a component for evaluating the living body by comparing the baseline measurement data and the current brain activity data.05-19-2011

Patent applications by Erwin Roy John, Mamaroneck, NY US

Justin V. John, Schenectady, NY US

Patent application numberDescriptionPublished
20110257864SYSTEMS, METHODS, AND APPARATUS FOR DETECTING FAILURE IN GAS TURBINE HARDWARE - Certain embodiments of the invention may include systems, methods, and apparatus for detecting failure in gas turbine hardware. According to an example embodiment of the invention, a method for detecting a failure in a gas turbine is provided. The method can include monitoring a parameter associated with the turbine, wherein the monitored parameter comprises at least one turbine bucket temperature, detecting an event associated with operation of the turbine, wherein the event is based at least in part on the monitored parameter, and initiating shutdown of the turbine upon detection of the event wherein the monitored parameter is above a predetermined value for at least a predetermined time duration.10-20-2011
20120016636SYSTEMS, METHODS, AND APPARATUS FOR DETERMINING STEADY STATE CONDITIONS IN A GAS TURBINE - Certain embodiments of the invention may include systems, methods, and apparatus for determining steady state conditions in a gas turbine. According to an example embodiment of the invention, a method for determining stability in a gas turbine is provided. The method can include receiving a guide vane (VGV) command and a fuel stroke reference (FSR) command associated with a gas turbine control system, determining a filtered VGV change based at least in part on the received VGV command, determining a filtered FSR change based at least in part on the received FSR command, and outputting a unit stability signal after a pickup delay time when the filtered VGV change is less than a predetermined VGV stability threshold and the filtered FSR change is less than a predetermined FSR stability threshold.01-19-2012

Justin Varkey John, Cohoes, NY US

Patent application numberDescriptionPublished
20110100096Method and System for Fluid Valve Leak Detection - A method detection of leakage through at least one first valve includes admitting an amount of fluid into a first control volume in operable communication with the at least one first valve, thereby pressurizing the first control volume. The first control volume is isolated and a rate of change of pressure in a second control volume in operable communication with the at least one first valve is measured. A system for detecting leakage across at least one first valve includes a first control volume receptive of an amount of fluid and a second control volume in flow communication with the first control volume. At least one first valve is located between the first control volume and the second control volume, and a rate of change in pressure in the second control volume indicates a rate of leakage through the at least one first valve.05-05-2011

Michael S. John, Larchmont, NY US

Patent application numberDescriptionPublished
20100217341Functional Ferrule - Described here are intracranial ferrules, systems, and methods for sensing and stimulating neural tissues. The ferrules are generally designed to include a holding area for retaining an implantable device. In some variations, the ferrule itself may perform the sensing and stimulating functions. In other variations, the ferrule may function to sense data from neural tissues and the implantable device may function to stimulate neural tissues. In yet other variations, the ferrule may function to stimulate, and the implantable device may function to sense data from, the neural tissues. The sensing and stimulating functions may be used to detect and/or treat various neurological conditions.08-26-2010

Patent applications by Michael S. John, Larchmont, NY US

Moore P. John, New York, NY US

Patent application numberDescriptionPublished
20100041875MODIFIED GP140 ENVELOPE POLYPEPTIDES OF HIV-1 ISOLATES, COMPOSITIONS, STABILIZED TRIMERIC COPLEXES, AND USES THEREOF - This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.02-18-2010

Richard A. John, Yorktown Heights, NY US

Patent application numberDescriptionPublished
20110193661Integrated Electromechanical Relays - Electromechanical relays and semiconductor structures and microelectromechanical systems including at least part of an electromechanical relay are presented. For example, an electromechanical relay includes an electrically conductive terminal within a printed circuit board, one or more electrically conductive contacts, and one or more magnetic actuators. The one or more magnetic actuators are respectively associated with the one or more electrically conductive contacts and each magnetic actuator includes (i) a magnetic core within at least one via extending through one or more layers of the printed circuit board, and (ii) an electrical coil around at least a portion of the magnetic core and within one or more layers of the printed circuit board. Activation of the one or more actuators causes electrical contact between the terminal and an associated one of the one or more electrically conductive contacts.08-11-2011

Samantha Margaret John, Brooklyn, NY US

Patent application numberDescriptionPublished
20120136701Method and system for faciliating interactive commercials in real time - The present invention discloses a method and a system for facilitating interactive commercials to users. The invention includes a client in the form of an application running on a display device and a server. The client may be in the form of a TV operating system. The method includes extracting audio from a commercial and generating a fingerprint from the extracted audio. The fingerprint as generated is sent by the client to the server. The server includes a database of commercials. After receiving the fingerprint, the server performs matching of the fingerprint with a set of commercials present in the database. Based on the match found, the server displays results. If a match is found, the server sends one or more instructions to the client device to initiate the interactive flow. Otherwise, the server returns an empty string.05-31-2012

Tanya John, Bronx, NY US

Patent application numberDescriptionPublished
20100301079MULTIFUNCTIONAL BAG - The present invention described herein is directed to a multi-purpose bag that satisfies the need of allowing the user to fix it to his/her body while keeping the hands free, and is designed to have a sufficient volume so as to have the space to keep the items such as credit cards, money, lip gloss, mirror and the like.12-02-2010