Patent application number | Description | Published |
20140264009 | DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF - An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions. | 09-18-2014 |
20140353491 | CREATING AN ION-ION REACTION REGION WITHIN A LOW-PRESSURE LINEAR ION TRAP - Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume. In various embodiments, the methods and systems can operated at reduced pressures. | 12-04-2014 |
20140357502 | Windowing Combined with Ion-Ion Reactions for Chemical Noise Elimination - In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged. | 12-04-2014 |
20140374591 | IN SITU GENERATION OF OZONE FOR MASS SPECTROMETERS - In some embodiments, a mass spectrometer capable of performing OzID is disclosed that can provide ozone in situ within an evacuated chamber of the spectrometer, e.g., within a collision cell or within the vacuum chamber of the mass spectrometer. In some embodiments, a corona discharge generated within the evacuated chamber can be employed to convert an ozone precursor delivered to the chamber into ozone. | 12-25-2014 |
20150097113 | Modulation of Instrument Resolution Dependant upon the Complexity of a Previous Scan - Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample. | 04-09-2015 |
20150129762 | REDUCING INTERFERENCES IN ISOBARIC TAG-BASED QUANTIFICATION - Methods and systems for performing mass spectrometry of analytes labeled with isobaric tags are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can enable enhanced discrimination between an analyte of interest and one or more interfering species when using isobaric tagging techniques. | 05-14-2015 |
20150235828 | METHOD AND SYSTEM FOR QUANTITATIVE AND QUALITATIVE ANALYSIS USING MASS SPECTROMETRY - In some embodiments, a quantitative analysis of at least one ion signal associated with a sample, which is detected by a mass spectrometer having at least two tandem quadrupole instruments, is employed to select one of the following operational modes for further mass analysis of the sample: (a) utilizing both quadrupole instruments as mass resolving filters, and (b) utilizing one quadrupole instrument as a mass resolving filter and utilizing the other as a linear ion trap. In some embodiments, the quantitative analysis of the ion signal comprises comparing the ion signal intensity with a predefined threshold. | 08-20-2015 |
20150260684 | METHOD AND APPARATUS FOR ION MOBILITY SPECTROMETRY - Methods and systems for performing mass spectrometry are provided herein. The method includes ionizing one or more compounds to generate ions, passing the ions into an ion mobility spectrometer, providing ozone, reacting the ions with ozone to produce ozone-induced fragment ions, and performing mass analysis and detection of the ozone-induced fragment ions. The system can comprise an ion source for ionizing one or more compounds to generate ions, an ion mobility spectrometer for receiving and separating the ions, an ozone supply for introducing ozone into the system; a reaction region for reacting the ions with the ozone to produce ozone-induced fragment ions, and a mass spectrometer for performing mass analysis and detection of the ozone-induced fragment ions. | 09-17-2015 |
20150318154 | Scheduled MS3 for Quantitation - Systems and methods are provided for scheduled MS | 11-05-2015 |
Patent application number | Description | Published |
20100241175 | PEDICLE SCREWS AND METHODS OF USING THE SAME - Pedicle screws that can include a pedicle screw body, housing, plurality of clamps, rod, and set screw are disclosed herein. The clamps may be positioned side by side inside the lower portion of the housing. When the rod and set screw are provided in the housing, the set screw applies a force on the rod and the rod engages the plurality of clamps, causing the clamps to frictionally engage a head of the pedicle screw between the clamps. | 09-23-2010 |
20110022097 | BONE PLATE SCREW-BLOCKING SYSTEMS AND METHODS - A bone plate screw-blocking system and method that comprises a plate with at least two bone screw receiving holes, blocking elements, bone screws, and a tool capable of simultaneously actuating at least two blocking elements. The plate includes an upper surface and a lower surface with bone screw receiving holes that extend through both surfaces of the plate. The bone screws couple the plate to the bone via the bone screw receiving holes. The blocking elements are movably positioned proximate each bone screw receiving hole. In an initial unblocked position, the blocking elements do not cover the bone screw receiving holes. Upon movement into final blocked positions, the blocking elements cover at least a portion of the bone screw receiving holes and preferably extend over at least a portion of the bone screw during use. | 01-27-2011 |
20110268596 | FLUID DEVICE WITH FLEXIBLE RING - A fluid device includes a housing defining a fluid inlet and a fluid outlet. A variable displacement assembly is in fluid communication with the fluid inlet and the fluid outlet. The variable displacement assembly includes a rotor assembly, a flexible ring, and a plurality of ring supports. The rotor assembly includes a rotor having a plurality of reciprocating members. The flexible ring is disposed about the rotor assembly. The flexible ring includes an inner surface, which is adapted for engagement with the plurality of reciprocating members, and an outer surface. The plurality of ring supports is disposed about the flexible ring. Each of the plurality of ring supports includes a support portion and a pivot portion about which the ring support selectively pivots. The support portion is adapted for engagement with the outer surface of the flexible ring. | 11-03-2011 |
20120022594 | MINIMALLY INVASIVE SURGICAL TOWER ACCESS DEVICES AND RELATED METHODS - Devices and methods are provided for assisting in spinal stabilization. An access device is provided that includes an outer sleeve, inner sleeve, spring latch and lock nut. The inner sleeve includes compressible grasping elements. The access device can be coupled to a screw head by sliding the outer sleeve relative to the inner sleeve and compressing the grasping elements. The coupled access device and screw can then be delivered to a target location in a patient. After providing two or more access devices, a rod member can be delivered using a rod insertion device. The rod member can serve as a connection between the two screws, and can provide spinal stabilization. An anti-torque device and a persuading device can be used to help ensure that the rod member is placed and secured in a proper location within a patient. | 01-26-2012 |
20120042774 | DISPLACEMENT ASSEMBLY FOR A FLUID DEVICE - A displacement assembly includes a rotor and a plurality of reciprocating members in engagement with the rotor. The displacement assembly further includes a ring assembly. The ring assembly defines a cam surface that is in engagement with the reciprocating members. The ring assembly has a first ring and an axially adjacent second ring with at least one of the first and second rings being adapted for selective movement relative to the other between a neutral position and a displaced position. The first ring has a first ring portion defining a bore that has an inner surface. The second ring has a second ring portion defining a bore that has an inner surface. A first circumferential portion of the inner surface of the first ring portion and a second circumferential portion of the inner surface of the second ring portion define the cam surface in the displaced position. | 02-23-2012 |
20120303064 | PEDICLE SCREWS AND METHODS OF USING THE SAME - Pedicle screws that can include a pedicle screw body, housing, plurality of clamps, rod, and set screw are disclosed herein. The clamps may be positioned side by side inside the lower portion of the housing. When the rod and set screw are provided in the housing, the set screw applies a force on the rod and the rod engages the plurality of clamps, causing the clamps to frictionally engage a head of the pedicle screw between the clamps. | 11-29-2012 |
20130144387 | SPINAL IMPLANT DEVICES AND METHODS - Systems, devices and methods relating to a spinal implant for placement in a disc space of a spine are described. A spinal implant ( | 06-06-2013 |
20130204306 | BONE PLATE SCREW-BLOCKING SYSTEMS AND METHODS - A bone plate screw-blocking system and method that comprises a plate with at least two bone screw receiving holes, blocking elements, bone screws, and a tool capable of simultaneously actuating at least two blocking elements. The plate includes an upper surface and a lower surface with bone screw receiving holes that extend through both surfaces of the plate. The bone screws couple the plate to the bone via the bone screw receiving holes. The blocking elements are movably positioned proximate each bone screw receiving hole. In an initial unblocked position, the blocking elements do not cover the bone screw receiving holes. Upon movement into final blocked positions, the blocking elements cover at least a portion of the bone screw receiving holes and preferably extend over at least a portion of the bone screw during use. | 08-08-2013 |
20130211462 | DRILL GUIDE WITH ANCHORING MEMBER - The present invention relates to a surgical drill guide having an anchoring mechanism for locking the drill guide to a bone plate. The anchoring mechanism is adapted to be received through an opening of a bone plate and rotated to lock the drill guide to the bone plate. The anchoring mechanism can be rotated by a driver, which has a distal end key that fits into a corresponding socket of on the proximal portion of the anchoring mechanism. The present invention also relates to a kit including a bone plate, a driver, and the drill guide and a method for using the kit to perform surgery. | 08-15-2013 |
20130245358 | CERVICAL BONE GROWTH STIMULATORS UTILIZING COMBINED MAGNETIC FIELD THERAPY - Cervical bone growth stimulators utilizing combined magnetic field therapy is provided. | 09-19-2013 |
20140073836 | SYSTEMS AND METHODS FOR PROMOTING BONE GROWTH UTILIZING AN AUTOMATICALLY ADJUSTABLE, PROGRAMMABLE COMBINED MAGNETIC FIELD THERAPY - The present invention relates to a system and method of applying a therapeutic electrical field to a bone region of a human being in order to promote healing and growth that that bone region. The present invention also provides a system that produces a combined magnetic field (CMF) that is precisely located and controlled across the entire treatment area requiring bone growth stimulation by utilizing bone dimensional input parameters to automatically calculate and drive the appropriate output therapy single through a single coil. | 03-13-2014 |
20140249583 | MINIMALLY INVASIVE SURGICAL TOWER ACCESS DEVICES AND RELATED METHODS - Devices and methods are provided for assisting in spinal stabilization. An access device is provided that includes an outer sleeve, inner sleeve, spring latch and lock nut. The inner sleeve includes compressible grasping elements. The access device can be coupled to a screw head by sliding the outer sleeve relative to the inner sleeve and compressing the grasping elements. The coupled access device and screw can then be delivered to a target location in a patient. After providing two or more access devices, a rod member can be delivered using a rod insertion device. The rod member can serve as a connection between the two screws, and can provide spinal stabilization. An anti-torque device and a persuading device can be used to help ensure that the rod member is placed and secured in a proper location within a patient. | 09-04-2014 |
20140371800 | BONE PLATE SCREW-BLOCKING SYSTEMS AND METHODS - A bone plate screw-blocking system and method that comprises a plate with at least two bone screw receiving holes, blocking elements, bone screws, and a tool capable of simultaneously actuating at least two blocking elements. The plate includes an upper surface and a lower surface with bone screw receiving holes that extend through both surfaces of the plate. The bone screws couple the plate to the bone via the bone screw receiving holes. The blocking elements are movably positioned proximate each bone screw receiving hole. In an initial unblocked position, the blocking elements do not cover the bone screw receiving holes. Upon movement into final blocked positions, the blocking elements cover at least a portion of the bone screw receiving holes and preferably extend over at least a portion of the bone screw during use. | 12-18-2014 |
20150134005 | PEDICLE SCREWS AND METHODS OF USING THE SAME - Pedicle screws that can include a pedicle screw body, housing, plurality of clamps, rod, and set screw are disclosed herein. The clamps may be positioned side by side inside the lower portion of the housing. When the rod and set screw are provided in the housing, the set screw applies a force on the rod and the rod engages the plurality of clamps, causing the clamps to frictionally engage a head of the pedicle screw between the clamps. | 05-14-2015 |