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John F. Engelhardt, Iowa City US

John F. Engelhardt, Iowa City, IA US

Patent application numberDescriptionPublished
20080206198Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders - Agents and methods to alter epithelial sodium channel (ENaC) activity.08-28-2008
20080206792Method of identifying compounds useful to treat neuronal degenerative diseases - Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.08-28-2008
20080213221Compounds and methods to enhance rAAV transduction - Agents and methods to alter rAAV transduction are provided.09-04-2008
20080226600Adeno-associated viruses and uses thereof - The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.09-18-2008
20080249050Compounds and methods to enhance rAAV transduction - Agents and methods to alter rAAV transduction are provided.10-09-2008
20080261201Methods and compounds to alter virus infection - The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.10-23-2008
20090017062Methods and compounds to alter virus infection - The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.01-15-2009
20090239243Method of identifying compounds useful to treat neuronal degenerative diseases - Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.09-24-2009
20090241206METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES - The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.09-24-2009
20090265796Adeno-associated virus vectors - The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.10-22-2009
20110054247METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES - The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.03-03-2011

Patent applications by John F. Engelhardt, Iowa City, IA US