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| 20100052026 | DEEP TRENCH CAPACITOR FOR SOI CMOS DEVICES FOR SOFT ERROR IMMUNITY - A semiconductor structure is disclosed. The semiconductor structure includes an active semiconductor layer, a semiconductor device having a gate disposed on top of the active semiconductor layer, and source and drain regions and a body/channel region disposed within the active semiconductor layer, an insulator layer having a first and second side, the first side being adjacent to the active semiconductor layer, a substrate disposed adjacent to the second side of the insulator layer, a deep trench capacitor disposed under the body/channel region of the semiconductor device. The deep trench capacitor electrically connects with and contacts the body/channel region of the semiconductor device, and is located adjacent to the gate of the semiconductor device. The semiconductor structure increases a critical charge Qcrit, thereby reducing a soft error rate (SER) of the semiconductor device. | 03-04-2010 |
| 20100054057 | Memory Sensing Method and Apparatus - Techniques for sensing data states of respective memory cells in a memory array are provided, the memory array including at least a first bit line coupled to at least a subset of the memory cells. In one aspect, a circuit for sensing data states of respective memory cells in the memory array includes at least one sense amplifier coupled to the first bit line. The sense amplifier includes a first transistor operative to selectively inhibit charging of the first bit line in a manner which is independent of a voltage level on a second bit line coupled to the sense amplifier. | 03-04-2010 |
| 20110199837 | High Voltage Word Line Driver - A word line driver circuit coupled to a memory circuit word line includes pull-up, pull-up clamp, pull-down and pull-down clamp transistors, each having a source, a drain and a gate. For the pull-up transistor, the source is coupled to a first power supply, and the gate to a pull-up control signal. For the pull-up clamp transistor, the source is coupled to the drain of the pull-up transistor, the drain to the word line, and the gate to a pull-up clamp gate signal. For the pull-down transistor, the source is coupled to a second power supply, and the gate to a pull-down control signal. For the pull-down clamp transistor, the source is coupled to the drain of the pull-down transistor, the drain to the word line, and the gate to a pull-down clamp gate signal. The word line is coupled to one or more DRAM cells. Source to drain voltage magnitudes of the pull-up and pull-down transistors are less than a voltage between the first and second power supplies. | 08-18-2011 |
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| 20100286877 | Temperature Dependent Minimum Transmission Input Speed - A system and method is employed to regulate a minimum transmission input speed based on automatic fluid temperature. The system includes a temperature sensor for sensing a temperature of the automatic transmission fluid and a controller for setting a minimum engine speed of the engine based on the temperature of the automatic transmission fluid. The size of a transmission pump may be reduced while the pump is still able to supply enough automatic transmission fluid to friction elements and gear ratios to provide lubrication and enable friction element actuators to engage and disengage the friction elements in a timely and effective manner. In a preferred form of the invention, when the temperature of the automatic transmission fluid is below 210° F., the minimum engine speed is set to no greater than 900 rpm; and when the temperature of the automatic transmission fluid is above 210° F., the minimum engine speed is set to no less than 1000 rpm. | 11-11-2010 |
| 20110155714 | Powertrain Driveline Warm-up System and Method - A powertrain/driveline warm-up system includes a vehicle controller, an electrical power source interfacing with the vehicle controller, at least one heater interfacing with the vehicle controller and at least a portion of a vehicle powertrain provided in thermal contact with the at least one heater. | 06-30-2011 |
| 20120080287 | Dry-Clutch Transmission with Cooling Techniques - The present disclosure relates to a dry-clutch transmission having various cooling techniques. Some techniques include forming different structural features on transmission components so as to create an organized air flow. The disclosed techniques are applicable to both opened and closed transmission housings. | 04-05-2012 |
| 20120123635 | POWERTRAIN THERMAL MANAGEMENT SYSTEM FOR A DRY-CLUTCH TRANSMISSION - The present disclosure relates to systems and methods for controlling a flow regulator, such as a diverter valve, that is configured to guide air through a transmission housing before entering an engine intake manifold. In certain arrangements, the flow regulator operates according to predetermined conditions, e.g., meeting an engine intake manifold air temperature threshold. | 05-17-2012 |
| 20120191306 | Vehicle with Transmission Cooling System - The present disclosure relates to a control circuit for a vehicle transmission cooling system having a controller configured to control an air compressor to selectively pressurize a transmission clutch housing and provide air to an alternative vehicle subsystem (or subsystems). | 07-26-2012 |
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| 20130040619 | ACQUIRING SAFETY STATUS INFORMATION - A method begins by a processing module obtaining a set of identifiers (IDs) corresponding to a set of user devices, wherein each user device of the set of user devices is associated with a corresponding safety status level. For each identifier (ID) of the set of IDs, the method continues with the processing module generating a safety status request that includes the ID, outputting the safety status request to a user device of the set of user devices that corresponds to the ID, receiving a safety status response of a set of safety status responses, wherein the safety status response includes a corresponding safety status level of one user device of the set of user devices, and indicating the safety status level of the safety status response when an ID of the safety status response compares favorably to at least one ID of the set of IDs. | 02-14-2013 |
| 20130040661 | PROVIDING SAFETY STATUS INFORMATION - A method begins by a processing module receiving a safety status request for a safety status level associated with a user device and determining whether to generate a safety status response. When generating a safety status response, the method continues with the processing module obtaining the safety status level associated with the user device and determining whether to include location information in the safety status response. When including the location information, the method continues with the processing module obtaining location coordinates corresponding to the user device, obtaining street address location information based on the location coordinates, generating the location information based on the location coordinates and the street address location information, generating the safety status response to include the safety status level and the location information, and outputting the safety status response to a requesting entity. | 02-14-2013 |
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| 20090275382 | METHOD FOR INTERACTING A DISPLAY WITH MECHANICAL REELS - Various methods for interacting with mechanical reels via a video screen are disclosed. In one embodiment, the method comprises providing a gaming machine having one or more mechanical reels positioned behind a video screen, wherein the video screen includes a touch screen and user interface for receiving user input. The mechanical reels spin and generate a game outcome, visible to the player through a video screen. A request is received, via the user interface, to rearrange the placement order of the mechanical reels, and the rearranged order of the mechanical reels is displayed on the video screen. | 11-05-2009 |
| 20090275383 | MECHANICAL REELS WITH INTERACTIVE DISPLAY - Systems for enhancing a mechanical reel game are disclosed. In one embodiment, the gaming machine includes a video screen having a touch screen, and a set of mechanical reels positioned behind the video screen. A user interface is displayed on the video screen and is configured to receive user input to rearrange the placement order of the mechanical reels. The video screen then displays the mechanical reels in the rearranged order. | 11-05-2009 |
| 20090275386 | MECHANICAL REELS WITH INTERACTIVE DISPLAY AND RELATED METHODS - Methods for enhancing a mechanical reel game are disclosed. According to one method, a game is initiated by spinning a plurality of mechanical reels in response to a player wager, wherein each mechanical reel has a plurality of game symbols. The gaming machine ascertains whether a triggering event is established during the game. In response to a triggering event, one or more video images are presented and overlay one or more the mechanical reels to obscure the game symbols on the mechanical reels in response to the triggering event. In one embodiment, the video images include one or more video depictions of game symbols. The mechanical reels obscured by the video images are fixed, and the mechanical reels not obscured by the video images are spun. One or more paylines are evaluated for winning outcomes based on the combination of the video depictions of game symbols and the game symbols presented on the mechanical reels on the one or more paylines. A bonus prize is awarded for a winning outcome appearing on a payline. | 11-05-2009 |
| 20120165089 | METHOD FOR INTERACTING A DISPLAY WITH MECHANICAL REELS - Various methods for interacting with mechanical reels via a video screen are disclosed. In one embodiment, the method comprises providing a gaming machine having one or more mechanical reels positioned behind a video screen, wherein the video screen includes a touch screen and user interface for receiving user input. The mechanical reels spin and generate a game outcome, visible to the player through a video screen. A request is received, via the user interface, to rearrange the placement order of the mechanical reels, and the rearranged order of the mechanical reels is displayed on the video screen. | 06-28-2012 |
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| 20110081693 | PERHYDROLASE FOR ENZYMATIC PERACID PRODUCTION - A process is provided for rapidly producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with a source of peroxygen, such as hydrogen peroxide, in the presence of an enzyme catalyst comprising an enzyme having identity to an acetyl xylan esterase from | 04-07-2011 |
| 20110136907 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-09-2011 |
| 20110136908 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-09-2011 |
| 20110150857 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-23-2011 |
| 20110152368 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-23-2011 |
| 20110152369 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-23-2011 |
| 20110152370 | PERHYDROLASE PROVIDING IMPROVED PERACID STABILITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-23-2011 |
| 20110236335 | PERHYDROLASE PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 09-29-2011 |
| 20110236336 | PERHYDROLASE PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 09-29-2011 |
| 20110236337 | PERHYDROLASE PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 09-29-2011 |
| 20110236338 | PERHYDROLASE PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 09-29-2011 |
| 20110236339 | PERHYDROLASE PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 09-29-2011 |
| 20110244535 | Production Of Peracids Using An Enzyme Having Perhydrolysis Activity - A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided. | 10-06-2011 |
| 20120156155 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156156 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156157 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156158 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156159 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156160 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156161 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
| 20120156162 | PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY - An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a | 06-21-2012 |
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| 20100147359 | Modular Solar Panel Racking System - Disclosed herein are embodiments of modular racking systems for solar panels and in particular, modular solar panel racks, racking systems, arrays of racks, kits and methods of use. One embodiment of a modular solar panel rack comprises a plurality of discrete ballast holders and a plurality of panel support members each having two upright portions, a transverse portion contiguously connected between the two upright portions, the connection such that the transverse portion is non-perpendicular to the two upright portions, and a retainer attached to the transverse portion and configured to retain a solar panel. Each of the plurality of ballast holders is connected to no more than four panel support members, each ballast holder perpendicularly connected to one of the upright portions. | 06-17-2010 |
| 20100276558 | MOUNTING SYSTEMS FOR SOLAR PANELS - Mounting systems for mounting solar panels to a surface are disclosed and can include panel clamp assemblies and rail clamp assemblies. Panel clamp assemblies can comprise a panel clamp having a base and arms extending from edges of the base, the base having an aperture, a rail clamp having a central portion with an aperture and two flexible tabs extending from the central portion on opposing sides of the aperture and a fastener threaded through the apertures such that that flexible tabs contact a head of the fastener and the arms extend in an opposite direction from the flexible tabs. Rail clamp assemblies can comprise a base member having a bottom and two side walls, the bottom having at least one aperture and each side wall having an elongated aperture, two clamping members and a fastener, wherein the side walls of the base member are positioned such that the opening is of sufficient size to receive the rail. | 11-04-2010 |
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| 20110290909 | MULTI-COMPONENT INSECT ATTRACTANT - Certain embodiments of the present invention employ insect-attracting liquid mixtures, solid mixtures, liquid solutions, and solid solutions that include two or more insect-attracting substances or compounds with different physical characteristics that lead to multi-component plumes comprising component plumes with different radii and multiple chemical gradients. Additional embodiments of the present invention include multi-component insect-attracting substances that effectively target two or more different types of insects that together comprise a target group of insects, and additionally target a particular sex, in certain embodiments, or both sexes, in other embodiments, of the target insects. Many of the insect-attracting-substance embodiments of the present invention, upon controlled vaporization or release, create a multi-component, three-dimensional plume that leads insects to the source of the plume along multiple chemical-concentration gradients. The insect-attracting-substance embodiments of the present invention can be incorporated within lures, traps, and other devices and more complex substances related to insect attraction. In one embodiment of the present invention, a multi-component insect-attracting substance comprises a combination of raspberry ketone and methyl eugenol that is effective, contrary to prior expectations and results, for attracting both oriental fruit flies and melon flies. | 12-01-2011 |
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| 20120102918 | METHOD OF MIXING EXHAUST GAS EXITING AN EXHAUST STACK OUTLET WITH COOLING AIR EXITING A COOLING PACKAGE OUTLET AND MACHINE USING SAME - A machine includes an internal combustion engine disposed within an engine compartment and supported on a machine frame. An exhaust stack has an inlet fluidly connected to an exhaust manifold of the internal combustion engine and an outlet in fluid communication with ambient air. A diesel particulate filter is disposed along the exhaust stack. A cooling package includes at least one heat exchanger and a blower fan. The blower fan is configured to blow cooling air from the engine compartment sequentially through the at least one heat exchanger and an outlet of the cooling package. Exhaust gas exiting the exhaust stack outlet is mixed with the cooling air exiting the cooling package outlet in a high temperature zone surrounding the exhaust stack outlet to form a fluid mixture, and a temperature of the fluid mixture at a perimeter of the high temperature zone is below 200 degrees Celsius. | 05-03-2012 |
| 20120102919 | METHOD OF MIXING EXHAUST GAS EXITING AN EXHAUST STACK OUTLET WITH COOLING AIR EXITING A COOLING PACKAGE OUTLET INCLUDING A REGENERATION CONTROL ALGORITHM AND MACHINE USING SAME - A machine includes an internal combustion engine disposed within an engine compartment and supported on a machine frame. An exhaust stack has an inlet fluidly connected to an exhaust manifold of the internal combustion engine and an outlet in fluid communication with ambient air. A diesel particulate filter is disposed along the exhaust stack, and the machine includes an active regeneration system for regenerating the diesel particulate filter. A cooling package including at least one heat exchanger and a blower fan. The blower fan is configured to blow cooling air from the engine compartment sequentially through the at least one heat exchanger and an outlet of the cooling package. Exhaust gas exiting the exhaust stack outlet is mixed with the cooling air exiting the cooling package outlet in a high temperature zone surrounding the exhaust stack outlet to form a fluid mixture. An electronic control module is in control communication with the active regeneration system and includes a regeneration control algorithm operable to detect a speed of the blower fan. | 05-03-2012 |
| 20120103711 | DIESEL PARTICULATE FILTER PACKAGING AND METHOD OF DIRECTING AIRFLOW IN A SKID STEER MACHINE - A skid steer machine includes an operator cage supported on a skid steer machine frame, a pair of lift arms pivotably attached to the skid steer machine frame behind the operator cage and extending longitudinally on both sides of the operator cage, and a rear mounted engine compartment supported on the skid steer machine frame. The rear mounted engine compartment includes an internal combustion engine, a diesel particulate filter fluidly connected to the internal combustion engine and positioned between the internal combustion engine and the operator cage, and a cooling package having a predominantly horizontal orientation. The cooling package is at a higher location within the rear mounted engine compartment than the diesel particulate filter. | 05-03-2012 |
| 20120103712 | SKID STEER MACHINE HAVING PIVOTABLY MOUNTED COOLING SYSTEM AND NON-METALLIC VIBRATION ISOLATOR - A skid steer machine includes an operator cage supported on a skid steer machine frame. A pair of lift arms are pivotably attached to the skid steer machine frame behind the operator cage and extend longitudinally on both sides of the operator cage. A cooling package includes a first heat exchanger and a second heat exchanger, and a blower fan configured to blow air in parallel through the first heat exchanger and the second heat exchanger. The cooling package is pivotably mounted to the skid steer machine frame using at least one pivotable mounting assembly and is pivotable between an operational position and a maintenance position. At least one non-metallic vibration isolator is positioned between the cooling package and the skid steer machine frame. | 05-03-2012 |
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| 20110174491 | BOTTOM HOLE ASSEMBLY WITH PORTED COMPLETION AND METHODS OF FRACTURING THEREWITH - A ported completion and method for use in fracturing multi-zone wells. A casing assembly having a plurality of casing lengths and one or more collars positioned so as to couple together the casing lengths. The collars may be a tubular body having an inner flow path, one or more fracture ports configured to provide fluid communication between an outer surface of the collar and the inner flow path, one or more valve holes intersecting the fracture ports, one or more valve vent holes positioned to provide fluid communication between the valve holes and the inner flow path, and one or more valves positioned in the valve holes for opening and closing the fracture ports. The valves are configured to open when a pressure differential is created between the fracture ports and the valve vent holes. The valve vent hole may be an annulus around the perimeter of the tubular body. | 07-21-2011 |
| 20110308817 | Multi-Zone Fracturing Completion - A ported housing that may be connected along a casing string and the method for use of the ported housing in fracturing and/or treating multiple zones in a well. A sleeve is connected to the ported housing and may be moved between an initial position that prevents fluid flow through the ports of the housing and second position that permits fluid flow through the ports. A bottom hole assembly may be connected to the sleeve by an anchor. A packer element may create a seal between the bottom hole assembly and the sleeve permitting a pressure differential across the packer element to move bottom hole assembly down the casing moving the sleeve to the second position. In the second position, the formation adjacent to the ported housing may be stimulated and/or treated. | 12-22-2011 |
| 20120097398 | Multi-Zone Fracturing Completion - A wellbore completion is disclosed. The wellbore completion comprises a casing assembly comprising a plurality of casing lengths. At least one collar is positioned so as to couple the casing lengths. The at least one collar comprises a tubular body having an inner flow path and at least one fracture port configured to provide fluid communication between an outer surface of the collar and the inner flow path. A length of coiled tubing can be positioned in the casing assembly. The coiled tubing comprises an inner flow path, wherein an annulus is formed between the coiled tubing and the casing assembly. A bottom hole assembly is coupled to the coiled tubing. The bottom hole assembly comprises a fracturing aperture configured to provide fluid communication between the inner flow path of the coiled tubing and the annulus. A packer can be positioned to allow contact with the at least one collar when the packer is expanded. The packer is capable of isolating the annulus above the packer from the annulus below the packer so that fluid flowing down the coiled tubing can cause a pressure differential across the packer to thereby open the fracture port. | 04-26-2012 |
| 20120160516 | System and Method for Positioning a Bottom Hole Assembly in a Horizontal Well - A system of couplings and method of use of the couplings to locate a downhole tool connected to coiled tubing, such as a bottom hole assembly, within a selected segment of a casing string. The selected segment of casing may be a ported collar or ported housing that permits the treatment and/or stimulation of the adjacent well formation. The system of couplings may be two, three, or four couplings that are spaced apart at predetermined lengths. The predetermined lengths may be shorter than typical lengths of casing segments. The distance between the first and second coupling may be substantially identical to the distance between the third and fourth coupling. The use of distances between the couplings that are shorter than the length of conventional casing segments may provide surface indicators as to the location of the bottom hole assembly with a higher confidence than relying on a traditional tally sheet. | 06-28-2012 |
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| 20100173428 | Protein Phosphorylation By Basophillic Serine/Threonine Kinases - The invention discloses 461 novel phosphorylation sites identified in basophilic Ser/Thr kinase signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 07-08-2010 |
| 20110045603 | Serine, Threonine, and Tyrosine Phosphorylation Sites - The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 02-24-2011 |
| 20110104820 | Tyrosine, Serine, And Threonine Phosphorylation Sites - The invention discloses 94 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 05-05-2011 |
| 20110111424 | ANALYSIS OF UBIQUITINATED POLYPEPTIDES - The invention relates to antibody reagents that specifically bind to peptides carrying a ubiquitin remnant from a digested or chemically treated biological sample. The reagents allow the technician to identify ubiquitinated polypeptides as well as the sites of ubiquitination on them. The reagents are preferably employed in proteomic analysis using mass spectrometry. The antibody reagents specifically bind to the remnant of ubiquitin (i.e., a diglycine modified epsilon amine of lysine) left on a peptide which as been generated by digesting or chemically treating ubiquitinated proteins. The inventive antibody reagents' affinity to the ubiquitin remnant does not depend on the remaining amino acid sequences flanking the modified (i.e., ubiquitinated) lysine, i.e., they are context independent. | 05-12-2011 |
| 20110244445 | Mass spectroscopy analysis of mutant polypeptides in biological samples - The invention relates to a method for determining the presence of at least one distinct polypeptide in a biological sample comprising contacting the biological sample with a hydrolyzing agent, wherein the hydrolyzing agent is capable of hydrolyzing the distinct polypeptide in a sequence-specific manner such that at least one distinct peptide having a predetermined peptide measured accurate mass would result if the at least one distinct polypeptide were present in the biological sample, to obtain a hydrolyzed sample; bringing the hydrolyzed sample in contact with a substrate comprising at least one immobilized binding partner, wherein the at least one immobilized binding partner is capable of specifically binding the distinct peptide; removing the hydrolyzed sample from the substrate in a manner such that the distinct peptide would remain bound to the immobilized binding partner; contacting the substrate with an elution solution, wherein the distinct peptide would dissociate from the immobilized binding partner into the elution solution; subjecting a portion of the elution solution to liquid chromatography to segregate a plurality of molecules in the portion of the elution solution to obtain sorted molecules; determining the measured accurate mass of at least one sorted molecule present in the elution solution; and determining the presence of the at least one distinct polypeptide in the biological sample when a measured accurate mass of at least one molecule is substantially equal to the predetermined peptide measured accurate mass. | 10-06-2011 |
| 20120208985 | Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif - There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. | 08-16-2012 |
| 20120308555 | METHODS AND REAGENTS FOR CREATING MONOCLONAL ANTIBODIES - In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a polyclonal population of antibodies such as a non-specific polyclonal population or a polyclonal population of antibodies that specifically bind to the antigen. The method includes obtaining nucleic acid molecules encoding heavy and light immunoglobulin chains (or variable regions thereof) of multiple immunoglobulins from an animal; obtaining mass spectra information of peptide fragments of a population of polyclonal immunoglobulins that specifically bind to an antigen of choice; comparing and/or correlating the mass spectra information of the peptide fragments of the polyclonal immunoglobulins with predicted mass spectra information of predicted amino acid sequences encoded by the nucleic acid molecules, and then assembling the heavy and light chains to create an antibody (or variable region thereof) that specifically binds to the antigen. | 12-06-2012 |
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| 20080290670 | Sealing system and method - An apparatus for connecting a plurality of structures, such as ends of a sealing ring, with each end defining an aperture therein and with the ring being adapted to mount a meter to a meter box structure. The apparatus comprises a locking pin with a distal end adapted to be insertable through each of the apertures of the first and second ends of the ring. The locking pin comprises a head member having at least an engageable end and a fracturable member. The locking pin further comprises a shaft portion having the distal end. The apparatus further comprises a lock housing adapted to retain at least a part of the shaft portion such that the first and second ends of the ring are connected between the head member of the locking pin and the lock housing. The head member has an outer surface adapted to receive at least two opposing forces, the at least two opposing forces being of sufficient magnitude to break the fracturable member. A lock removal tool is adapted to receive and fracture a portion of the locking pin, enabling removal of the lock assembly from the meter box sealing ring. In an example embodiment an apparatus and method is provided for securing at least one structure or a plurality of structures, used with a utility service enclosure, or for example, a meter box locking ring having, for example, flanged ends or used to seal for example, utility enclosures, meter boxes or trucking, shipping, airline or other transportation containers or enclosures. An example embodiment also provides a tamper-evident locking apparatus or seal that is adapted to indicate tampering. | 11-27-2008 |
| 20100000270 | LOCKING APPARATUS AND METHOD - An apparatus for connecting a plurality of structures, such as ends of a sealing ring, with each end defining an aperture therein and with the ring being adapted to mount a meter to a meter box structure. The apparatus comprises a locking pin with a distal end adapted to be insertable through each of the apertures of the first and second ends of the ring. The locking pin comprises a head member having at least an engageable end and a fracturable member. The locking pin further comprises a shaft portion having the distal end. The apparatus further comprises a lock housing adapted to retain at least a part of the shaft portion such that the first and second ends of the ring are connected between the head member of the locking pin and the lock housing. The head member has an outer surface adapted to receive at least two opposing forces, the at least two opposing forces being of sufficient magnitude to break the fracturable member. A lock removal tool is adapted to receive and fracture a portion of the locking pin, enabling removal of the lock assembly from the meter box sealing ring. In an example embodiment an apparatus and method is provided for securing at least one structure or a plurality of structures, used with a utility service enclosure, or for example, a meter box locking ring having, for example, flanged ends or used to seal for example, utility enclosures, meter boxes or trucking, shipping, airline or other transportation containers or enclosures. An example embodiment also provides a tamper-evident locking apparatus or seal that is adapted to indicate tampering. | 01-07-2010 |
