| Patent application number | Description | Published |
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| 20080230478 | Regeneration Of A Chromatography Matrix - The present invention relates to a process of regenerating a separation matrix, such as a chromatography matrix, comprising adsorption of at least one target molecule by contacting a mobile phase comprising at target molecule(s) with a matrix; removal of unbound material by washing the matrix; elution of target molecule(s) by contacting the matrix with an eluent; reducing regeneration by contacting said matrix with a reducing agent; alkaline regeneration by contacting the matrix with an alkaline solution; and equilibration of the matrix. | 09-25-2008 |
| 20090264630 | METHOD OF SEPARATING MONOMERIC PROTEIN(S) - The present invention relates to a method of separating one or more monomeric proteins, such as monomeric antibodies, from a liquid. The method comprises providing a thiophilic aromatic chromatography matrix; contacting the liquid that comprises proteins with the matrix; and recovering at least one monomeric protein, such as a monomeric antibody, from the flow-through fraction. The proteins are advantageously monomeric antibodies. | 10-22-2009 |
| 20100022760 | MUTANT PROTEIN - The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for example be derived from a protein capable of binding to other regions of the immunoglobulin molecule than the complementarity determining regions (CDR), such as protein A, and preferably the B-domain of Staphylococcal protein A. The invention also relates to a matrix for affinity separation, which comprises an immunoglobulin-binding protein as ligand coupled to a solid support, in which protein ligand at least one asparagine residue has been mutated to an amino acid other than glutamine. | 01-28-2010 |
| 20110118442 | CHROMATOGRAPHY LIGAND - The present invention relates to a chromatography ligand defined by the following formula R | 05-19-2011 |
| 20110266225 | CHROMATOGRAPHY LIGAND - The present invention relates to a chromatography ligand defined by the following formula R | 11-03-2011 |
| 20120149875 | AFFINITY CHROMATOGRAPHY MATRIX - The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the adsorbed immunoglobulin containing proteins; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods being that each of the ligands consists essentially of a monomer or dimer SpA or protein Z or a functional variant thereof. | 06-14-2012 |
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| 20100291636 | METHOD FOR INTRODUCING COMMON AND/OR INDIVIDUAL SEQUENCE ELEMENTS IN A TARGET NUCLEIC ACID MOLECULE - The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps: i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample nucleic acid molecules; ii) bringing the sample nucleic acid molecules in contact with primary, secondary and tertiary probe nucleic acid molecules, wherein the 3′-end of the tertiary probe comprise a part complementary to the primary probe and the 5′-end of the tertiary probe comprise a part complementary to a 5′-part of the target nucleic acid molecule; the 3′-end of the secondary probe is complementary to a 3′-part of the target nucleic acid molecule and the 5′-end of the secondary probe is not complementary to the target nucleic acid molecule; wherein said primary, secondary and tertiary probes comprise said common and/or individual sequence elements; iii) ligating the 3′-end of the primary probe to the 5′-end of the target nucleic acid molecule; and iv) elongating the 3′-end of the secondary probe by means of a nucleic acid polymerase; or iv′) elongating the 3′-end of the target nucleic acid molecule. | 11-18-2010 |
| 20120220479 | PROBES FOR SPECIFIC ANALYSIS OF NUCLEIC ACIDS - The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said single-stranded portion is sufficient to allow hybridisation of at least part of the single-stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single-stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single-stranded portion of said target fragment, and comprising at the other end a second non-target-specific part which comprises a nucleotide sequence complementary to at least a portion, including one end, of oligonucleotide B of the probe, and (ii) oligonucleotide B is a single-stranded oligonucleotide which may contain or carry at least one element for detection and/or enrichment of said target fragment, and of which at least a portion, including one end, is complementary in sequence to the second non-target-specific part of oligonucleotide A, such that said target fragment becomes annealed to said probe through hybridisation to the first target-specific part of oligonucleotide A resulting in only one target-specific probe-binding event per target fragment; (d) ligating oligonucleotide B of said probe to the part of the single-stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) detecting or enriching for said probe-target fragment hybrid. Kits for use in the method of the invention are also provided. | 08-30-2012 |
| Patent application number | Description | Published |
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| 20120002630 | Method and Apparatus for Uplink Multi-Carrier Transmit Diversity | 01-05-2012 |
| 20120122466 | Method and Arrangement in a Communications Network - A method for enhancing Random Access Channel, RACH, performance is provided. First timing settings to be used by a first set of user equipments for a first Acquisition Indicator Channel, AICH, response timing is explicitly or implicitly signalled ( | 05-17-2012 |
| 20120163512 | PROCESSING NODES AND METHODS OF ESTIMATING INTERFERENCE IN A RADIO TELECOMMUNICATION NETWORK - A processing node ( | 06-28-2012 |
| 20120196637 | Uplink Transmit Diversity - The present invention discloses a method in a wireless access network node for controlling a UE. The UE comprises at least two transmit antennas, and is capable of uplink transmit diversity. There is an antenna weight associated with each transmit antenna. First, the wireless access network node determines that the antenna weights of the user equipment may be controlled. Then, it creates a control signal that comprises control information and transmits it to the user equipment. The control information controls a UE autonomous selection of the antenna weights in the UE. | 08-02-2012 |
| 20120202555 | Method and Apparatus for Supporting Uplink Transmit Diversity - The present invention relates to a method and a user equipment for use in a wireless communication system that allow for improved uplink transmit diversity performance by using downlink measurements for making informed decisions on whether or not to change precoding vector for uplink transmission. The user equipment measures ( | 08-09-2012 |
| 20130077657 | FINGER PLACEMENT IN MULTI-STAGE INTERFERENCE CANCELLATION - In a receive node of a wireless network, an iterative multi-user multi-stage interference cancellation receiver is used. After each stage of interference cancellation, interference characteristics change. An adaptive finger placement strategy is used in which after each stage of interference cancellation, finger delays and combining weights of the receiver are adapted to reflect the changed interference characteristics. | 03-28-2013 |
| 20130077670 | IMPAIRMENT COVARIANCE AND COMBINING WEIGHT UPDATES DURING ITERATIVE TURBO INTERFERENCE CANCELLATION RECEPTION - In a receive node of a wireless network, an iterative multi-user multi-stage interference cancellation receiver is used. After each stage of interference cancellation, interference characteristics change. An adaptive strategy is used in which after each stage of interference cancellation, impairment covariance is parametrically updated and combining weights of the receiver are adapted to reflect the updated impairment covariance. | 03-28-2013 |
| 20130077720 | MULTI-STAGE TURBO EQUALIZATION AND INTERFERENCE CANCELLATION RECEIVER FOR WIRELESS SYSTEMS - In a receive node of a wireless network, an iterative multi-user multi-stage interference cancellation receiver is used. The receiver performs code-averaged equalization and chip chip-level code-specific interference over-cancellation on the received signals. This can result in a unified interference cancellation processing, and can avoid cumbersome calculations of code cross correlations that is required in symbol-level interference cancellation. A symbol-level code-averaged desired signal add-back is performed to address the over-cancellation of some desired signals. | 03-28-2013 |
